Allele Dmel\aos^Δ7

General Information
Symbol	Dmel\aos^Δ7	Species	D. melanogaster
Name		FlyBase ID	FBal0043093
Feature type	allele	Associated gene	Dmel\aos
Also Known As	argos^Δ7, argos^IΔ7, argos^lΔ7, aos^d7, argos^delta7, argos^1Δ7

Allele class	amorphic allele - genetic evidence, loss of function allele
Mutagen	Delta2-3, P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Freeman et al., 1992, Wemmer and Klaembt, 1995, Schweitzer et al., 1995, Stemerdink and Jacobs, 1997) loss of function allele (Szuts et al., 1997)
Mutagen	Delta2-3 (Freeman et al., 1992) P-element activity (Wemmer and Klaembt, 1995, Stemerdink and Jacobs, 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	aos^W11 (Freeman et al., 1992, Stemerdink and Jacobs, 1997)
Nature of the lesion	Statement Reference Excision of the P{lwB} element. (Stemerdink and Jacobs, 1997) Excision of a P-element causing deletion of the first exon encoding the putative ATG start codon and signal sequence. (Wemmer and Klaembt, 1995) Deletion caused by imprecise excision of the P{lwB} element of argos^W11. Deletion removes the 5' exon and the beginning of the major open reading frame. (Freeman et al., 1992)
Cytology
Phenotypic Data
Phenotypic Class
	cell polarity defective (with aos^5F4) (Strutt and Strutt, 2003, Strutt and Strutt, 2003) cell polarity defective (with aos^A254Δ15) (Strutt and Strutt, 2003) cell polarity defective (with aos^rlt) (Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003) lethal (Schweitzer et al., 1995) lethal (with Df(3L)st-f13) (Wemmer and Klaembt, 1995) lethal (with Df(3L)st-k7) (Wemmer and Klaembt, 1995) lethal \| embryonic stage (with Df(3L)st-g18) (Wemmer and Klaembt, 1995) lethal \| embryonic stage \| recessive (Freeman et al., 1992) visible (with aos²⁵⁷) (Zartman et al., 2009) visible (with aos^p1) (Zartman et al., 2009) visible (with aos^W11) (Zartman et al., 2009) visible (with Df(3L)Exel6129) (Alvarado et al., 2006)
Phenotype Manifest In
	1st posterior cell (Palsson and Gibson, 2000) 2nd posterior cell (Palsson and Gibson, 2000) abdominal lateral pentascolopidial chordotonal organ lch5 \| supernumerary (Elstob et al., 2001) chordotonal organ \| lateral (Scholz et al., 1997, Scholz et al., 1997) denticle belt (Szuts et al., 1997) denticle belt (with aos^Δ5) (Simcox, 1997) dorsal acute muscle \| ectopic (Carmena et al., 2002) dorsal acute muscle \| ectopic \| precursor (Carmena et al., 2002) dorsal appendage (with aos^W11) (Wasserman and Freeman, 1998) dorsal appendage \| maternal effect (with aos^W11) (Zartman et al., 2009) dorsal appendage \| somatic clone (Wasserman and Freeman, 1998) dorsal oblique muscle \| ectopic (Carmena et al., 2002) dorsal oblique muscle \| ectopic \| precursor (Carmena et al., 2002) embryonic/larval oenocyte \| supernumerary (Elstob et al., 2001, Brodu et al., 2004) embryonic/larval oenocyte precursor \| supernumerary (Brodu et al., 2004) embryonic/larval optic lobe (Daniel et al., 1999) embryonic/larval recurrent nerve (Dumstrei et al., 1998) embryonic head (Freeman et al., 1992) embryonic ventral epidermis (Freeman et al., 1992) eye (with aos²⁵⁷) (Zartman et al., 2009) eye (with aos^p1) (Zartman et al., 2009) eye (with aos^W11) (Zartman et al., 2009) eye (with Df(3L)Exel6129) (Alvarado et al., 2006) eye (with Df(3L)st-f13) (Wemmer and Klaembt, 1995) eye (with Df(3L)st-k7) (Wemmer and Klaembt, 1995) eye \| posterior (with aos⁰⁵⁸⁴⁵) (Voas and Rebay, 2003) eye \| somatic clone (Freeman et al., 1992) eye photoreceptor cell \| ectopic (with aos^5F4) (Strutt and Strutt, 2003) eye photoreceptor cell \| ectopic (with aos^A254Δ15) (Strutt and Strutt, 2003) eye photoreceptor cell \| ectopic (with aos^rlt) (Strutt and Strutt, 2003) eye photoreceptor cell \| somatic clone \| supernumerary (Charroux et al., 2006) frontal ganglion (Dumstrei et al., 1998) genital disc primordium (Chen et al., 2005) hypocerebral ganglion (Dumstrei et al., 1998) hypostomal sclerite (Shandala et al., 1999) midline glial cell (Scholz et al., 1997, Stemerdink and Jacobs, 1997, Scholz et al., 1997) mystery cell (with aos^5F4) (Strutt and Strutt, 2003) oenocyte primordium (Brodu et al., 2004) ommatidial precursor cluster (with aos^5F4) (Strutt and Strutt, 2003) ommatidium (with aos^5F4) (Strutt and Strutt, 2003) ommatidium (with aos^A254Δ15) (Strutt and Strutt, 2003) ommatidium (with aos^rlt) (Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003) optic lobe (Dumstrei et al., 1998) pericardial cell \| ectopic (Carmena et al., 2002) pericardial cell \| ectopic \| precursor (Carmena et al., 2002) photoreceptor cell R1 \| somatic clone (Freeman et al., 1992) photoreceptor cell R2 \| somatic clone (Freeman et al., 1992) photoreceptor cell R3 \| ectopic (with aos^5F4) (Strutt and Strutt, 2003) photoreceptor cell R3 \| somatic clone (Freeman et al., 1992) photoreceptor cell R4 \| ectopic (with aos^5F4) (Strutt and Strutt, 2003) photoreceptor cell R4 \| somatic clone (Freeman et al., 1992) photoreceptor cell R5 \| somatic clone (Freeman et al., 1992) photoreceptor cell R6 \| somatic clone (Freeman et al., 1992) photoreceptor cell R8 \| somatic clone (Yang and Baker, 2001) presumptive embryonic/larval central nervous system (Scholz et al., 1997, Scholz et al., 1997)
Detailed Description
	Statement Reference Virtually all eggs derived from egg chambers containing complete homozygous follicle cell clones appear normal and have two dorsal appendages. (Lachance et al., 2009) argos[Δ7]/+ flies have normal eyes at 20[o]C. (Mao and Freeman, 2009) argos[Δ7]/argos[257], argos[Δ7]/argos[W11] and argos[Δ7]/argos[p1] flies have blisters in the eye. Eggs derived from females with mosaic argos[Δ7] egg chambers have the normal number of two dorsal appendages. Only 5% of eggs derived from argos[Δ7]/argos[W11] females have defects in dorsal appendage morphology, which include a reduced distance between the two appendages and appendages that are shorter than normal. (Zartman et al., 2009) argos^Δ7/Df(3L)Exel6129 flies have eyes with a roughened appearance and prominent blistering along the posterior margin. (Alvarado et al., 2006) argos^Δ7 clones in the eye disc induce the formation of extra photoreceptor cells; 46.2% of ommatidia within these clones have 8 photoreceptor cells, 40.7% of ommatidia have 9, 11.1% have 10 and 1% have 11. (Charroux et al., 2006) Stage 15 argos^Δ7 embryos have ~36 genital disc precursor cells, while wild type embryos have only 22 at this stage. (Chen et al., 2005) Stage 16 argos[Δ7] homozygous embryos have more oenocytes per cluster than wild-type. Unlike rho[Scer\UAS.cdCa]; Scer\GAL4[en-e16E] the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3. Analysis of larval oenocyte precursor delamination shows that it occurs continuously rather than in widely spaced cycles with 3 delaminating cells per cycle as seen in wild-type. In the resulting oenocyte clusters terminal differentiation of some oenocytes is blocked or delayed. (Brodu et al., 2004) argos^rlt/argos^Δ7 animals exhibit a ommatidial rotation phenotype. (Gaengel and Mlodzik, 2003) In argos^5F4/argos^Δ7 transheterozygotes 45% of adult ommatidia have extra photoreceptors. Many of the ommatidia with a normal complement of photoreceptor cells have polarity defects up to 59% of ommatidia are misrotated, while only 5% appear achiral and usually less than 1% have the wrong chirality. It appears that a transformation of mystery cells to photoreceptor R3/R4 is the cause of the extra photoreceptor cells. When the eye discs of these mutants are examined about 60% of immature clusters exhibit extra photoreceptor precursor cells. In row 7-8 the number of extra cells decreases to about 25%. In the adult only about 15% of clusters have ectopic R3/R4 cells. (Strutt and Strutt, 2003) 63% of ommatidia in argos^Δ7/argos^A254Δ15 animals exhibit extra R cells. Of those that ommatidia that remain about 47% exhibit misrotations, about 10% exhibit achirality, and about 4% exhibit the wrong chirality. About 43% of ommatidia in argos^Δ7/argos^5F4 animals exhibit extra R cells. Of those that ommatidia that remain about 45% exhibit misrotations, about 5% exhibit achirality, and none exhibit the wrong chirality. About 11% of ommatidia in argos^Δ7/argos^rlt animals exhibit extra R cells. Of those that ommatidia that remain about 52% exhibit misrotations, about 1% exhibit achirality, and about 1% exhibit the wrong chirality. Of the misrotated ommatidia just less than half are underrotated. (Strutt and Strutt, 2003) argos^Δ7/argos⁰⁵⁸⁴⁵ escaper adults have extensive blistering along the posterior edge of the eye. (Voas and Rebay, 2003) Extra EPCs (eve-positive heart associated or pericardial cells) and DA1 and DO2 founders (and subsequently muscles) are seen in mutant embryos. Additional founders of the P2 and p15 lineages of the developing embryonic mesoderm are seen. (Carmena et al., 2002) Homozygous clones in the adult abdomen do not show any consistent alterations of normal polarity. (Lawrence et al., 2002) Ommatidial spacing is not affected in argos^Δ7 somatic clones in the eye, even in very large clones. (Baonza et al., 2001) The number of chordotonal organs in the lateral cluster is increased from 5 to 6 in mutant embryos. In stage 11 embryos, the oenocyte precursor whorl is enlarged and contains many extra cells and by stage 16 oenocyte clusters containing 15-27 cells are seen. (Elstob et al., 2001) Homozygous clones in the eye disc that include several ommatidia show no defects in R8 precursor specification. Positioning of R8 precursors is unaffected by mutant cells in posterior columns. In larger clones that are more than 10 ommatidia wide the pattern of R8 specification is disrupted. (Yang and Baker, 2001) Heterozygotes show a quantitative effect on wing shape in intervein regions C and D compared to wild type. (Palsson and Gibson, 2000) Mutant embryos show a 'cyclops' phenotype in which the optic lobes are enlarged and show dorsal fusion. (Daniel et al., 1999) Homozygous embryos have missing or malformed H-piece structures. (Shandala et al., 1999) At stage 16 optic lobes are enlarged and fused. Frontal and hypocerebral ganglion are enlarged and the recurrens nerve is thickened. (Dumstrei et al., 1998) Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc. (Sapir et al., 1998) Germline clones reveal no requirement for argos in the oocyte in patterning the egg, or in the viability or patterning of the embryo. Follicle cell clones cause a fused dorsal appendage phenotype. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed. argos^Δ7/argos^W11 hypomorphic females lay a significant proportion of eggs with fused dorsal appendages. (Wasserman and Freeman, 1998) Abnormal CNS axon pattern phenotype. An increase in number of midline glia and lateral chordotonal organs is also observed. (Scholz et al., 1997, Scholz et al., 1997) argos^Δ5/argos^Δ7 embryos exhibit expansion of the denticle belts. Wing, leg, haltere and eye/antenna argos^Δ5/argos^Δ7 mutant discs can be in vivo cultured. (Simcox, 1997) The number of midline glia cells is increased to an average of 5.3 +/- 0.2 cells per segment in homozygous embryos. (Stemerdink and Jacobs, 1997) Additional small denticles are often found located anteriorly to the abdominal denticle belts in homozygous embryos, in the most extreme cases forming a complete additional row anterior to row 1. Extra small denticles are also found in row 6, resulting in a slightly higher density of denticles compared to wild-type. (Szuts et al., 1997) Transheterozygotes with Df(3L)st-g18 die before hatching. Transheterozygotes with Df(3L)st-k7 or Df(3L)st-f13 have rare escapers, adult survivors develop a characteristic eye phenotype, bulging of the posterior part of the eye that spreads into the anterior part. (Wemmer and Klaembt, 1995) Homozygous clones in the eye cause extra outer photoreceptors, severity of the phenotype depends on the size of the clone. Homozygotes display severe disruption and broadening of the embryonic head skeleton, broadening of the ventral epidermis as shown by increased distance between the Keilin's organs. (Freeman et al., 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference aos[+]/aos^Δ7, sty^S73 has visible \| dominant phenotype, enhanceable by rho-5[+]/rho-5^KO1 (Zettl et al., 2011)
Enhancer of
Statement Reference aos[+]/aos^Δ7 is an enhancer of increased cell number \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of size defective \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of visible \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of visible \| dominant phenotype of rho-5[+]/rho-5^KO1, sty^S73 (Zettl et al., 2011) aos[+]/aos^Δ7 is an enhancer of visible \| dominant phenotype of Snr1^E1 (Curtis et al., 2011) aos[+]/aos^Δ7 is an enhancer of visible \| dominant phenotype of sty^S73 (Zettl et al., 2011) aos[+]/aos^Δ7 is an enhancer of visible phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of planar polarity defective phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003) aos^Δ7/argos[+] is an enhancer of planar polarity defective \| recessive phenotype of sl⁹ (Schlesinger et al., 2004) aos^Δ7 is an enhancer of cell polarity defective phenotype of fz²⁰/fz¹⁹ (Strutt and Strutt, 2003) aos^Δ7 is an enhancer of visible phenotype of bul¹ (Wemmer and Klaembt, 1995)
NOT Enhancer of
Statement Reference aos^Δ7/argos[+] is a non-enhancer of planar polarity defective phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003)
Suppressor of
Statement Reference aos[+], aos^Δ7, Ack^Scer\UAS.cSb, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of W^Ala5.GMR (Schoenherr et al., 2012) aos^Δ7 is a suppressor of cell polarity defective phenotype of Ras64B^V14.Act5C (Strutt and Strutt, 2003) aos^Δ7 is a suppressor of lethal phenotype of W^hs.PG (Bergmann et al., 1998) aos^Δ7 is a suppressor of visible phenotype of bul^D (Wemmer and Klaembt, 1995)
NOT Suppressor of
Statement Reference aos[+], aos^Δ7, Ack^{K156A.Scer\UAS}, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of W^Ala5.GMR (Schoenherr et al., 2012) aos[+]/aos^Δ7 is a non-suppressor of visible phenotype of W^Ala5.GMR (Schoenherr et al., 2012)
Other
Statement Reference aos^Δ7, sty^S73 has visible \| dominant phenotype (Casci et al., 1999, Casci et al., 1999)
Phenotype Manifest In
Enhanced by
Statement Reference aos[+]/aos^Δ7, sty^S73 has wing vein phenotype, enhanceable by rho-5[+]/rho-5^KO1 (Zettl et al., 2011) aos^Δ7/aos⁰⁵⁸⁴⁵ has eye phenotype, enhanceable by rno³/rno[+] (Voas and Rebay, 2003) aos^Δ7 has abdominal lateral pentascolopidial chordotonal organ lch5 \| supernumerary phenotype, enhanceable by salm^unspecified (Elstob et al., 2001) aos^Δ7 has dorsal acute muscle \| ectopic phenotype, enhanceable by Dl^X (Carmena et al., 2002) aos^Δ7 has dorsal acute muscle \| precursor \| ectopic phenotype, enhanceable by Dl^X (Carmena et al., 2002) aos^Δ7 has eye photoreceptor cell \| supernumerary \| somatic clone phenotype, enhanceable by Gug¹⁴⁹⁶⁷ (Charroux et al., 2006) aos^Δ7 has pericardial cell \| ectopic phenotype, enhanceable by Dl^X (Carmena et al., 2002) aos^Δ7 has pericardial cell \| precursor \| ectopic phenotype, enhanceable by Dl^X (Carmena et al., 2002)
Suppressed by
Statement Reference aos^Δ7 has dorsal acute muscle \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002) aos^Δ7 has dorsal acute muscle \| precursor \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002) aos^Δ7 has dorsal oblique muscle \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002) aos^Δ7 has dorsal oblique muscle \| precursor \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002) aos^Δ7 has pericardial cell \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002) aos^Δ7 has pericardial cell \| precursor \| ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.Scer\UAS (Carmena et al., 2002)
Enhancer of
Statement Reference aos[+]/aos^Δ7 is an enhancer of eye phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of photoreceptor cell R7 \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of wing blade phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of wing vein \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) aos[+]/aos^Δ7 is an enhancer of wing vein \| ectopic phenotype of sl² (Murillo-Maldonado et al., 2011) aos[+]/aos^Δ7 is an enhancer of wing vein \| ectopic phenotype of Snr1^E1 (Curtis et al., 2011) aos[+]/aos^Δ7 is an enhancer of wing vein phenotype of rho-5[+]/rho-5^KO1, sty^S73 (Zettl et al., 2011) aos[+]/aos^Δ7 is an enhancer of wing vein phenotype of sty^S73 (Zettl et al., 2011) aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of eye photoreceptor cell phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003) aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of ommatidium phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003) aos^Δ7/argos[+] is an enhancer of eye phenotype of Ras85D^V12.sev (Voas and Rebay, 2003) aos^Δ7/argos[+] is an enhancer of interommatidial bristle phenotype of sl⁹ (Schlesinger et al., 2004) aos^Δ7/argos[+] is an enhancer of ommatidium phenotype of Ras85D^V12.sev (Voas and Rebay, 2003) aos^Δ7/argos[+] is an enhancer of ommatidium phenotype of sl⁹ (Schlesinger et al., 2004) aos^Δ7/argos[+] is an enhancer of photoreceptor cell R7 \| supernumerary phenotype of sl⁹ (Schlesinger et al., 2004) aos^Δ7/argos[+] is an enhancer of photoreceptor cell R8 \| supernumerary phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7/argos[+] is an enhancer of photoreceptor cell R8 \| supernumerary phenotype of ed^k01102 (Spencer and Cagan, 2003) aos^Δ7/Scer\GAL4^tub.PU is an enhancer of wing vein phenotype of Scer\GAL4^tub.PU, csw^{Y279C.Scer\UAS.P\T} (Oishi et al., 2009) aos^Δ7 is an enhancer of abdominal lateral pentascolopidial chordotonal organ lch5 \| supernumerary phenotype of salm^unspecified (Elstob et al., 2001) aos^Δ7 is an enhancer of dorsal acute muscle \| ectopic phenotype of Dl^X (Carmena et al., 2002) aos^Δ7 is an enhancer of dorsal acute muscle \| precursor \| ectopic phenotype of Dl^X (Carmena et al., 2002) aos^Δ7 is an enhancer of eye phenotype of bul¹ (Wemmer and Klaembt, 1995) aos^Δ7 is an enhancer of eye phenotype of Cbl^{D.onc.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000) aos^Δ7 is an enhancer of eye phenotype of Cbl^Dv.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000) aos^Δ7 is an enhancer of eye phenotype of Fas2^EB112/Fas2^e76 (Mao and Freeman, 2009) aos^Δ7 is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹ (Strutt and Strutt, 2003) aos^Δ7 is an enhancer of pericardial cell \| ectopic phenotype of Dl^X (Carmena et al., 2002) aos^Δ7 is an enhancer of pericardial cell \| precursor \| ectopic phenotype of Dl^X (Carmena et al., 2002) aos^Δ7 is an enhancer of photoreceptor cell R7 phenotype of Cbl^Dv.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000) aos^Δ7 is an enhancer of wing vein \| ectopic phenotype of Cbl^Dv.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000) aos^Δ7 is an enhancer of wing vein phenotype of Cbl^{D.onc.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000)
NOT Enhancer of
Statement Reference aos^Δ7/argos[+] is a non-enhancer of eye photoreceptor cell phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003) aos^Δ7/argos[+] is a non-enhancer of ommatidium phenotype of Cct1¹⁶⁹¹⁹ (Weber et al., 2003) aos^Δ7/argos[+] is a non-enhancer of wing phenotype of N^55e11 (Weber et al., 2003) aos^Δ7 is a non-enhancer of chemosensory ventral triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-enhancer of dorsal triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-enhancer of dorsocentral bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-enhancer of scutellar bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003)
Suppressor of
Statement Reference aos[+], aos^Δ7, Ack^Scer\UAS.cSb, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of W^Ala5.GMR (Schoenherr et al., 2012) aos^Δ7 is a suppressor of dorsal oblique muscle phenotype of Egfr^DN.Scer\UAS, Scer\GAL4^twi.PB (Carmena et al., 2002) aos^Δ7 is a suppressor of eye phenotype of arm^S56F.GMR (Freeman and Bienz, 2001) aos^Δ7 is a suppressor of eye phenotype of bul^D (Wemmer and Klaembt, 1995) aos^Δ7 is a suppressor of eye phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) aos^Δ7 is a suppressor of ommatidium phenotype of Ras64B^V14.Act5C (Strutt and Strutt, 2003) aos^Δ7 is a suppressor of ommatidium phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) aos^Δ7 is a suppressor of pericardial cell phenotype of Egfr^DN.Scer\UAS, Scer\GAL4^twi.PB (Carmena et al., 2002)
NOT Suppressor of
Statement Reference aos[+], aos^Δ7, Ack^{K156A.Scer\UAS}, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of W^Ala5.GMR (Schoenherr et al., 2012) aos[+]/aos^Δ7 is a non-suppressor of eye phenotype of W^Ala5.GMR (Schoenherr et al., 2012) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R1 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R2 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R3 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R4 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R5 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R6 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R7 \| somatic clone \| third instar larval stage phenotype of rasp^T392 (Miura et al., 2006, Miura et al., 2006) aos^Δ7 is a non-suppressor of chemosensory ventral triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-suppressor of dorsal triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-suppressor of dorsocentral bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) aos^Δ7 is a non-suppressor of eye photoreceptor cell \| somatic clone phenotype of mop^T612 (Miura et al., 2008) aos^Δ7 is a non-suppressor of scutellar bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003)
Other
Statement Reference Ack^Scer\UAS.cSb, Scer\GAL4^GMR.PU, aos[+]/aos^Δ7 has pigment cell \| supernumerary phenotype (Schoenherr et al., 2012) aos^Δ7, sty^S73 has eye phenotype (Casci et al., 1999, Casci et al., 1999) aos^Δ7, sty^Δ5 has ommatidial precursor cluster \| somatic clone phenotype (Brown et al., 2006) Dl^X, aos^Δ7 has dorsal oblique muscle \| ectopic phenotype (Carmena et al., 2002, Carmena et al., 2002) Dl^X, aos^Δ7 has dorsal oblique muscle \| precursor \| ectopic phenotype (Carmena et al., 2002, Carmena et al., 2002) Gug¹⁴⁹⁶⁷, aos^Δ7, rho^7M43, ru¹ has eye photoreceptor cell \| somatic clone phenotype (Charroux et al., 2006, Charroux et al., 2006, Charroux et al., 2006, Charroux et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference Heterozygosity for aos[Δ7] does not suppress the small eye phenotype caused by W[Ala5.GMR]. Expression of Ack[K156A.Scer\UAS] under the control of Scer\GAL4[GMR.PU] in conjunction with aos[Δ7]/+ does not suppress the small eye phenotype caused by W[Ala5.GMR]. Expression of Ack[Scer\UAS.cSb] under the control of Scer\GAL4[GMR.PU] suppresses the small eye phenotype caused by W[Ala5.GMR]. Further suppression is seen if the flies are also heterozygous for aos[Δ7]/+. Animals expressing Ack[Scer\UAS.cSb] under the control of Scer\GAL4[GMR.PU] in a aos[Δ7]/+ background show a 25% increase in pigment cell number when assessed at 42% pupa development. (Schoenherr et al., 2012) One copy of aos[Δ7] enhances the reduction in wing blade area seen in homozygous sl[2] males. One copy of aos[Δ7] significantly enhances the ectopic wing vein phenotype seen in sl[2] homozygotes. One copy of aos[Δ7] dramatically enhances the percentage of sl[2] mutant ommatidia that contain extra R7 photoreceptors. The eyes also appear rougher than in sl[2] mutants alone. (Murillo-Maldonado et al., 2011) One copy of aos[Δ7] enhances the extra wing vein phenotype seen in sty[S73] heterozygotes at 29[o]C. One copy of aos[Δ7] enhances the extra vein phenotype seen in rho-5[KO1] sty[S73] double heterozygotes at 29[o]C. (Zettl et al., 2011) The rough-eye phenotype observed in Fas2[EB112]/Fas2[e76] flies is enhanced by the presence of argos[Δ7]/+. (Mao and Freeman, 2009) The presence of a argos[Δ7] background significantly enhances ectopic wing vein formation found in csw[Y279C.Scer\UAS] (Scer\GAL4[tub]) mutants. (Oishi et al., 2009) The loss of photoreceptor cells seen in homozygous mop[T612] clones in the eye disc is not rescued if the clones are also homozygous for argos[Δ7]. (Miura et al., 2008) argos^Δ7 does not protect Df(1)su(s)R194/+ clones in the eye; Df(1)su(s)R194/+ ; argos^Δ7 clones are not recovered in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). Also, argos^Δ7 does not prevent apoptosis of Df(1)su(s)R194/+ cells in the wing. (Tyler et al., 2007) argos^Δ7 sty^Δ5 Minute clones in the eye disc form large, disorganised clusters in the morphogenetic furrow compared to the clusters formed in wild-type eye discs. (Brown et al., 2006) The extra photoreceptor cell phenotype of argos^Δ7 clones is enhanced in argos^Δ7 Gug¹⁴⁹⁶⁷ clones, with a greater percentage of ommatidia showing supernumerary photoreceptor cells. These extra photoreceptor cells are never R8 cells. In contrast, ru¹ rho^7M43 Gug¹⁴⁹⁶⁷ argos^Δ7 mutant clones lack photoreceptor cells. (Charroux et al., 2006) The ed^4.12 R8 cell twinning phenotype is strongly enhanced by argos^Δ7/+. (Rawlins et al., 2003) argos^Δ7/+ mildly enhances the ed^k01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 18% to 34% in the double mutant flies. (Spencer and Cagan, 2003) The addition of argos^Δ7/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64B^V14.Act5C. (Strutt and Strutt, 2003) The eye blistering phenotype seen in argos^Δ7/argos⁰⁵⁸⁴⁵ escaper adults is enhanced by rno³/+, so that it covers much of the eye. The rough eye phenotype of Ras85D^V12.sev flies is enhanced by argos^Δ7/+. (Voas and Rebay, 2003) The notching seen in wings of N^55e11/+ flies is not enhanced in argos^Δ7/+ mutants. While Cct1¹⁶⁹¹⁹/+, argos^Δ7/+ double heterozygotes have no eye defects, N^55e11/+; Cct1¹⁶⁹¹⁹/+, argos^Δ7/+ triple heterozygotes show an enhancement in the defective eye phenotype (loss of photoreceptor cells, defects in ommatidial polarity and chirality and a partial loss of the ventral eye) seen in Cct1¹⁶⁹¹⁹ mutants. (Weber et al., 2003) The EPC and DA1 phenotype seen in argos^Δ7 and Dl^X exhibit a synergistic effect on each other when combined. An increase in the number of DO2 muscles is also seen. (Carmena et al., 2002) salm^unspecified argos^Δ7 double mutant embryos have a dramatic chordotonal organ overproduction phenotype that is more severe than that seen in either single mutant. 9 or more lateral chordotonal organs per hemisegment are frequently seen, that are often (as in salm^unspecified single mutants) scattered in lateral and dorsal positions. The double mutant embryos lack oenocytes. (Elstob et al., 2001) A argos[Δ7] background enhances the eye and wing vein phenotype of Scer\GAL4[GMR.PF] Cbl[Dv.Scer\UAS] mutants. (Robertson et al., 2000) sty^S73/argos^Δ7 double heterozygotes have a mild rough eye phenotype. (Casci et al., 1999) Transheterozygotes with bul^bp are semi-lethal, surviving adults display an eye phenotype. (Wemmer and Klaembt, 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	aos²⁵⁷ (Zartman et al., 2009) aos^p1 (Zartman et al., 2009) aos^W11 (Zartman et al., 2009)
Rescued by	aos^Δ7/Df(3L)Exel6129 is rescued by aos^Scer\UAS.cAa/Scer\GAL4^hs.2sev (Alvarado et al., 2006)
Partially rescued by	aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^{P372S.Scer\UAS}/Scer\GAL4^hs.2sev (Alvarado et al., 2006) aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^{S371F.Scer\UAS}/Scer\GAL4^hs.2sev (Alvarado et al., 2006) aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^{V146D.Scer\UAS}/Scer\GAL4^hs.2sev (Alvarado et al., 2006)
Not rescued by	aos^Δ7/Df(3L)Exel6129 is not rescued by aos^{C141Y.Scer\UAS}/Scer\GAL4^hs.2sev (Alvarado et al., 2006)
Comments
Stocks ( 2 )
Bloomington	1004 aos^Δ7/TM3, Sb¹
Kyoto	106162 aos^Δ7/TM3, Sb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	aos^1Δ7 (Szuts et al., 1998) aos^d7 (Weber et al., 2003, Chang et al., 2003, Daniel et al., 1999, Dumstrei et al., 1998) aos^delta7 (Firth et al., 2000) aos^IΔ7 (Szuts et al., 1997) aos^lΔ7 (Helman et al., 2011) aos^Δ7 (Voas and Rebay, 2003, Rawlins et al., 2003, Alvarez et al., 2003, Carmena et al., 2002, Yang and Baker, 2001, Shandala et al., 1999, Simcox, 1997, Tyler et al., 2007, Alvarado et al., 2006, Miura et al., 2006, Miura et al., 2008, Lachance et al., 2009, Oishi et al., 2009, Murillo-Maldonado et al., 2011, Oishi et al., 2006) arg^1Δ7 (Bergmann et al., 1998) argos^1Δ7 (Sapir et al., 1998, Charroux et al., 2006, Brown et al., 2006) argos^- (Lawrence et al., 2002) argos^delta7 (Chen et al., 2005, Melen et al., 2005) argos^Delta7 (Curtis et al., 2011) argos^gilD7 (Rawlins et al., 2003) argos^IΔ7 (Sudarsan et al., 2002, Baonza et al., 2001, Casci et al., 1999, Wasserman and Freeman, 1998, Gabay et al., 1997) argos^lΔ7 (Freeman and Bienz, 2001, Golembo et al., 1996, Schweitzer et al., 1995, Schlesinger et al., 2004, Mao and Freeman, 2009) argos^Δ7 (Schoenherr et al., 2012, Curtis et al., 2011, Brodu et al., 2004, Robertson et al., 2000, Djiane and Mlodzik, 2010, Zartman et al., 2009) gil^Δ7
Name Synonym	argos^IΔ7 (Zettl et al., 2011)
Secondary FlyBase IDs

References ( 62 )

Generate a list of	All references relating to this allele ( 62 )

List References by type	Research paper ( 59 ) Supplementary material ( 1 ) Erratum ( 1 ) Abstract ( 1 )
Recent research papers ( 5 )
	Schoenherr et al., 2012, PLoS Genet. 8(5): e1002725 Drosophila activated cdc42 kinase has an anti-apoptotic function. [FBrf0218372] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Murillo-Maldonado et al., 2011, PLoS ONE 6(11): e28067 Insulin Receptor-Mediated Signaling via Phospholipase C-γ Regulates Growth and Differentiation in Drosophila. [FBrf0216849] Zettl et al., 2011, Cell 145(1): 79--91 Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling. [FBrf0213387] Show all research papers ...

Allele Dmel\aosΔ7

Allele Dmel\aos^Δ7