mutant embryos have a lower ratio of mitosis to apoptosis compared to wild-type embryos. This ratio decreases further with age.
About 9/10 of prophases or metaphases show abnormal condensation. About 4/5 of gluk06821a
anaphase or telophase figures show chromatin bridges, those bridges that persist to telophase also show abnormal decondensation. Mutant brains are smaller and show higher levels of apoptosis than wild-type. 2.5% of cells in gluk06821a
brains are apoptotic (compared to 0.5% in wild-type). Mean chromosome length in gluk06821a
brains that have been incubated in colchicine does not differ from wild-type.
Embryos show anaphase bridges in mitotic domains.
Ventral and lateral PNS of homozygous embryos exhibit subtle organisation defects resulting in irregularly shaped clusters.