A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\knitRa

General Information
SymbolDmel\knitRaSpeciesD. melanogaster
NameFlyBase IDFBal0043140
Feature typealleleCreated / Updated2006-08-20/2006-08-20
Associated geneDmel\kni
Allele class
Mutagenin vitro construct | genomic fragment, in vitro construct | other
hide Nature of the Allele
Allele class
Mutagen
in vitro construct | genomic fragment
(Rothe et al., 1992, Pankratz et al., 1992)
in vitro construct | other
(Lunde et al., 1998)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      9.5kb genomic SalI-HindIII fragment including kni transcription unit and 6.5kb of flanking sequences.
      (Rothe et al., 1992)
      Fragment that contains the kni coding region and 6kb of flanking sequences.
      (Pankratz et al., 1992)
      Construct: kni upstream sequences, including the 5' end of the transcription unit and extending over 5kb upstream of the transcription unit drive kni expression.
      (Lunde et al., 1998)
      9.5kb SalI/HindIII fragment containing about 5.5kb of upstream sequences, the complete kni transcription unit (3 kb) and about 1kb of downstream sequences.
      (Nauber, 1999.8.30)
      Assay mode
      In transgenic Drosophila (intraspecific)
      (Pankratz et al., 1992, Lunde et al., 1998, Rothe et al., 1992)
      Carried in construct
      P{kniSH}
      (Pankratz et al., 1992, Fuss et al., 2001, Nauber, 1999.8.30, Rothe et al., 1992, Boube et al., 2001, Chen et al., 1998, Lunde et al., 1998)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      wild-type
      (Pankratz et al., 1992)
      hide Phenotype Manifest In
      embryonic dorsal branch
      (Ribeiro et al., 2002)
      hide Detailed Description
      Statement
      Reference
      The tracheal systems of knitRa; Df(3L)ri-XT1/+ embryos lack dorsal branches, but small 'trunk-like' buds are sometimes seen in their place.
      (Ribeiro et al., 2002)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Rescues
      knitRa rescues kniunspecified
      (Pankratz et al., 1992)
      Partially rescues
      knitRa partially rescues kni8
      (Chen et al., 1998, Rothe et al., 1992)
      knitRa partially rescues Df(3L)ri-XT1
      (Gonzalez-Gaitan et al., 1994)
      Comments
      Mutant abdominal phenotype of kni8 and Df(3L)ri-XT1 embryos can be rescued by knitRa but head defects are incompletely rescued.
      (Rothe et al., 1992)
      Expression of knitRa construct leads to the development of the SNS in Df(3L)ri-XT1 embryos.
      (Gonzalez-Gaitan et al., 1994)
      Fails to rescue the "ri" phenotype.
      (Lunde et al., 1998)
      Rescues the segmentation and tracheal phenotype of kni8.
      (Chen et al., 1998)
      hide Stocks ( 0 )
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      knicLa
       
      knitRa
       
      Name Synonym
      kni-transgene
      (Ribeiro et al., 2002)
      Secondary FlyBase IDs
      • FBal0034819
      • FBal0092910
      hide References ( 9 )
      Research paper
      Ribeiro et al., 2002, Dev. Cell 2(5): 677--683
      In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. [FBrf0148947]
      Boube et al., 2001, Genes Dev. 15(12): 1554--1562
      Specific tracheal migration is mediated by complementary expression of cell surface proteins. [FBrf0136944]
      Fuss et al., 2001, Mech. Dev. 100(1): 15--23
      Control of endoreduplication domains in the Drosophila gut by the knirps and knirps-related genes. [FBrf0132397]
      Chen et al., 1998, Development 125(24): 4959--4968
      The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development. [FBrf0105788]
      Lunde et al., 1998, Development 125(21): 4145--4154
      The knirps and knirps-related genes organize development of the second wing vein in Drosophila. [FBrf0104917]
      Gonzalez-Gaitan et al., 1994, Proc. Natl. Acad. Sci. USA 91(18): 8567--8571
      Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures. [FBrf0075001]
      Pankratz et al., 1992, Science 255: 986--989
      Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system. [FBrf0057643]
      Rothe et al., 1992, Nature 359: 156--159
      Loss of gene function through rapid mitotic cycles in the Drosophila embryo. [FBrf0057319]
      Personal communication to FlyBase
      Nauber, 1999.8.30, knirps constructs.
      knirps constructs. [FBrf0109190]