|Feature type||allele||Associated gene||Dmel\Klp61F|
|Also Known As||Klp61F2|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Klp61F/Klp61F trans-heterozygotes display larval lethality. Klp61F[Ubi-p63E.T:Avic\GFP] rescues the lethality of trans-heterozygous Klp61F/Klp61F mutants. The rescued flies are fertile and can be propagated as stable transgenic lines. The rescued embryos display a decrease in the rate of prometaphase-to-metaphase spindle elongation compared with wild type embryos, which leads to a small decrease in subsequent spindle length.
The brains of homozygous larvae have a reduced frequency of anaphase figures, and an increased frequency of polyploid figures and overcondensed chromosomes compared to wild-type. The brains and imaginal discs are approximately half normal size.
Homozygotes and hemizygotes die as late third instar larvae or early pupae. Neuroblasts isolated from third instar homozygous larvae show an increased mitotic index and complete lack of anaphase figures, indicating metaphase arrest. Chromosomes are hypercondensed compared to wild-type and highly polyploid cells are common.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 0 )|
|Notes on Origin|
Klp61F alleles form the following phenotypic series, from the most to the least severe: Klp61Furc-1 > Klp61Furc-3 > Klp61F06836, Klp61F07012 > Klp61F06345 > Klp61Furc-4.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 6 )|
|Personal communication to FlyBase|