FB2025_02 , released April 17, 2025
Allele: Dmel\Rexo5E497K
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General Information
Symbol
Dmel\Rexo5E497K
Species
D. melanogaster
Name
FlyBase ID
FBal0043730
Feature type
allele
Associated gene
Dmel\Rexo5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gerstberger et al., 2017)
Mutagen
ethyl methanesulfonate
(Anderson et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: E497K.

(Gerstberger et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:6,607,861..6,607,861 [+]
Nucleotide change:

G6607861A

Amino acid change:

E497K | Rexo5-PA; E497K | Rexo5-PB

Reported amino acid change:

E497K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Gerstberger et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rexo5E497K is rescued by Scer\GAL4Act.PU/Rexo5UAS.cGa

      (Gerstberger et al., 2017)

      Rexo5E497K is rescued by Rexo5+t4.5

      (Gerstberger et al., 2017)

      Rexo5E497K is rescued by Rexo5+t6.5

      (Gerstberger et al., 2017)
      Partially rescued by

      Rexo5E497K is partially rescued by Scer\GAL4Act.PU/Rexo5H493R.UAS

      (Gerstberger et al., 2017)
      Not rescued by

      Rexo5E497K is not rescued by Scer\GAL4Act.PU/Rexo5D361A.UAS

      (Gerstberger et al., 2017)

      Rexo5E497K is not rescued by Scer\GAL4Act.PU/Rexo5E363A.UAS

      (Gerstberger et al., 2017)

      Rexo5E497K is not rescued by Scer\GAL4Act.PU/Rexo5H493A.UAS

      (Gerstberger et al., 2017)

      Rexo5E497K is not rescued by Scer\GAL4Act.PU/Rexo5D446A.UAS

      (Gerstberger et al., 2017)

      Rexo5E497K is not rescued by Rexo5D361A.D446A.UAS/Scer\GAL4Act.PU

      (Gerstberger et al., 2017)

      Rexo5E497K is not rescued by Scer\GAL4Act.PU/Rexo5E363A.D446A.UAS

      (Gerstberger et al., 2017)
      Comments

      The second larval instar lethality of Rexo5E497K homozygotes is rescued by combination with either Rexo5+t4.5 or Rexo5+t6.5 or by expression of Rexo5Scer\UAS driven by Scer\GAL4Act.PU. Partial rescue (the larvae survive until the third instar stage) is achieved by expression of Rexo5H493R.Scer\UAS, but no rescue is effected by expression of any of the following: Rexo5D361A.Scer\UAS, Rexo5E363A.Scer\UAS, Rexo5H493A.Scer\UAS, Rexo5D446A.Scer\UAS, Rexo5D361A.D446A.Scer\UAS or Rexo5E363A.D446A.Scer\UAS (all tested with the Scer\GAL4Act.PU driver).

      Crossing Rexo5c04255 to Df(3L)BSC411 is lethal while Rexo5c04255/Df(3L)BSC410 flies are viable.

      (Gerstberger et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG8368M100
      (Gerstberger et al., 2017)
      Rexo5E497K
      (Gerstberger et al., 2017)
      l(3)65CEaM100
      Name Synonyms
      Secondary FlyBase IDs
        References (2)