FlyBase Allele Report: Dmel\phyl[2]

General Information

Symbol

Dmel\phyl²

Species

D. melanogaster

Name

FlyBase ID

FBal0044256

Feature type

allele

Associated gene

Dmel\phyl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Dickson et al., 1995)

Mutagen

ethyl methanesulfonate

(Dickson et al., 1996, Dickson et al., 1995)

Progenitor genotype

Cytology

Description

Point mutation leading to premature termination of translation.

(Dickson et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Pi et al., 2001, Dickson et al., 1996, Dickson et al., 1995)

lethal - all die during embryonic stage (with phyl¹)

(Pi et al., 2004)

lethal - all die during first instar larval stage (with phyl¹)

(Pi et al., 2004)

partially lethal - majority live (with phyl⁴)

(Pi et al., 2001)

visible (with phyl⁴)

(Pi et al., 2001)

visible | somatic clone

(Pi et al., 2004, Pi et al., 2001)

Phenotype Manifest In

adult abdominal segment 3 & chaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & microchaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & chaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & microchaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

cephalopharyngeal skeleton | germline clone

(Dickson et al., 1996)

chaeta | somatic clone

(Pi et al., 2004, Pi et al., 2001)

eo neuron | embryonic stage (with phyl¹)

(Pi et al., 2001)

filzkorper | germline clone

(Dickson et al., 1996)

mesothoracic tergum & chaeta (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & microchaeta (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

muscle cell of A1-7 dorsal oblique muscle 4 (with Df(2R)trix)

(Artero et al., 2003)

muscle cell of A1-7 lateral longitudinal muscle 1 (with Df(2R)trix)

(Artero et al., 2003)

photoreceptor cell R1

(Dickson et al., 1995)

photoreceptor cell R6

(Dickson et al., 1995)

photoreceptor cell R7

(Dickson et al., 1995)

thecogen cell | embryonic stage (with phyl¹)

(Pi et al., 2001)

tormogen cell | somatic clone | increased number

(Pi et al., 2001)

Detailed Description

Statement

Reference

phyl¹/phyl² animals die at late embryonic or first larval instar stages.

(Pi et al., 2004)

phyl²/Df(2R)trix embryos show loss of the LL1 and DO4 muscles.

(Artero et al., 2003)

The number of notal microchaetae and microchaetae on abdominal segments 3 and 4 are reduced in phyl²/phyl⁴ flies. 58% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 9.2% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 6.7% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 11.6% show other defects. Homozygous clones in the notum lack most bristles and the few remaining ones have a four socket phenotype. 75% of the neurons and 50% of the sheath cells of the es organs are missing in phyl¹/phyl² embryos, although most es organs form.

(Pi et al., 2001)

Embryos derived from homozygous germline clones show defects dissimilar to those caused by defective tor signalling: head skeleton and filzkorper are abnormal.

(Dickson et al., 1996)

Ommatidia of phyl²/phyl⁴ flies contain only 5 photoreceptor cells, an R8 and four cells of the R1-6 class. Rare ommatidia have five R1-R6 cells. This phenotype is also seen in clones of phyl² cells. Missing receptor cells are transformed to cone cells.

(Dickson et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

phyl²/phyl⁴ has visible phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has visible phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

Suppressed by

Statement

Reference

phyl²/phyl⁴ has visible phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has visible phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

NOT suppressed by

Statement

Reference

phyl² has visible | somatic clone phenotype, non-suppressible by Scer\GAL4^Eq/sens^UAS.cNa

(Pi et al., 2004)

Enhancer of

Statement

Reference

phyl²/phyl[+] is an enhancer of visible phenotype of sina³/sina²

(Pi et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

phyl²/phyl⁴ has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk^osn

(Pi et al., 2001)

Suppressed by

Statement

Reference

phyl²/phyl⁴ has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl¹/phyl² has eo neuron | embryonic stage phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11

(Pi et al., 2001)

phyl²/phyl⁴ has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

NOT suppressed by

Statement

Reference

phyl² has chaeta | somatic clone phenotype, non-suppressible by Scer\GAL4^Eq/sens^UAS.cNa

(Pi et al., 2004)

Enhancer of

Statement

Reference

phyl²/phyl[+] is an enhancer of adult abdominal segment 3 & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of adult abdominal segment 3 & microchaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of adult abdominal segment 4 & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of adult abdominal segment 4 & microchaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of mesothoracic tergum & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of mesothoracic tergum & microchaeta phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of mesothoracic tergum & tormogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

phyl²/phyl[+] is an enhancer of mesothoracic tergum & trichogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

phyl² is an enhancer of eye phenotype of Raf¹²

(Dickson et al., 1996)

phyl² is an enhancer of photoreceptor cell R1 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R2 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R3 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R4 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R5 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R6 phenotype of Raf¹²

(Dickson et al., 1995)

phyl² is an enhancer of photoreceptor cell R7 phenotype of Raf¹²

(Dickson et al., 1995)

NOT Enhancer of

Statement

Reference

phyl¹/phyl² is a non-enhancer of sensory neuron | increased number phenotype of ttk^osn

(Pi et al., 2001)

Suppressor of

Statement

Reference

phyl² is a suppressor of microchaeta | increased number phenotype of N^l1N-ts1

(Pi et al., 2001)

phyl² is a suppressor of eye phenotype of Raf::tor^12D.sev

(Dickson et al., 1996)

phyl² is a suppressor of photoreceptor cell R7 phenotype of Raf::tor^12D.hs.sev

(Dickson et al., 1995)

NOT Suppressor of

Statement

Reference

phyl¹/phyl² is a non-suppressor of sensory neuron | increased number phenotype of ttk^osn

(Pi et al., 2001)

Other

Statement

Reference

phyl², sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

phyl²/+ ; sinah¹/sinah¹ flies have no visible mutant phenotype.

(Cooper, 2007)

Expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^Eq1 fails to rescue external sensory organ formation in homozygous phyl² clones in the notum.

(Pi et al., 2004)

N^l1N-ts1 ; phyl¹/phyl² embryos show a reduction in the number of neurons in each abdominal hemisegment.

(Pi et al., 2001)

Dominantly suppresses the rough eye phenotype of phl::tor^12D.sev.

(Dickson et al., 1996)

Suppresses rough eye phenotype of phl::tor^12D.hs.sev, almost completely eliminating the extra R7 cells. Dominantly enhances the photoreceptor phenotype of phl¹² and 'sev³⁵¹'.

(Dickson et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

phyl¹/phyl² is partially rescued by phyl^3.4.ORF

(Pi et al., 2004)

phyl¹/phyl² is partially rescued by phyl^4.1.ORF

(Pi et al., 2004)

Not rescued by

phyl¹/phyl² is not rescued by phyl^3.4ΔES.ORF

(Pi et al., 2004)

phyl¹/phyl² is not rescued by phyl^3.4ΔE.ORF

(Pi et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Phyl²

(Cooper, 2007)

phyl^17L1

(Dickson et al., 1996)

phyl²

(Shi and Noll, 2009)

Name Synonyms

Secondary FlyBase IDs

References (9)

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