Allele Dmel\phyl²

General Information
Symbol	Dmel\phyl²	Species	D. melanogaster
Name		FlyBase ID	FBal0044256
Feature type	allele	Associated gene	Dmel\phyl

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Dickson et al., 1995)
Mutagen	ethyl methanesulfonate (Dickson et al., 1995, Dickson et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Point mutation leading to premature termination of translation. (Dickson et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (with phyl¹) (Pi et al., 2004) lethal \| first instar larval stage (with phyl¹) (Pi et al., 2004) lethal \| recessive (Pi et al., 2001, Dickson et al., 1996, Dickson et al., 1995) partially lethal - majority live (with phyl⁴) (Pi et al., 2001) visible (with phyl⁴) (Pi et al., 2001) visible \| somatic clone (Pi et al., 2001, Pi et al., 2004)
Phenotype Manifest In
	A1-7 dorsal oblique muscle 4 (with Df(2R)trix) (Artero et al., 2003) A1-7 lateral longitudinal muscle 1 (with Df(2R)trix) (Artero et al., 2003) adult abdominal segment 3 & chaeta (with phyl⁴) (Pi et al., 2001) adult abdominal segment 3 & microchaeta (with phyl⁴) (Pi et al., 2001) adult abdominal segment 3 & tormogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) adult abdominal segment 3 & trichogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) adult abdominal segment 4 & chaeta (with phyl⁴) (Pi et al., 2001) adult abdominal segment 4 & microchaeta (with phyl⁴) (Pi et al., 2001) adult abdominal segment 4 & tormogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) adult abdominal segment 4 & trichogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) cephalopharyngeal skeleton \| germline clone (Dickson et al., 1996) chaeta \| somatic clone (Pi et al., 2001, Pi et al., 2004) eo neuron \| embryonic stage (with phyl¹) (Pi et al., 2001) filzkorper \| germline clone (Dickson et al., 1996) mesothoracic tergum & chaeta (with phyl⁴) (Pi et al., 2001) mesothoracic tergum & microchaeta (with phyl⁴) (Pi et al., 2001) mesothoracic tergum & tormogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) mesothoracic tergum & trichogen cell \| supernumerary (with phyl⁴) (Pi et al., 2001) photoreceptor cell R1 (Dickson et al., 1995) photoreceptor cell R6 (Dickson et al., 1995) photoreceptor cell R7 (Dickson et al., 1995) socket \| somatic clone \| supernumerary (Pi et al., 2001) thecogen cell \| embryonic stage (with phyl¹) (Pi et al., 2001)
Detailed Description
	Statement Reference phyl¹/phyl² animals die at late embryonic or first larval instar stages. (Pi et al., 2004) phyl²/Df(2R)trix embryos show loss of the LL1 and DO4 muscles. (Artero et al., 2003) The number of notal microchaetae and microchaetae on abdominal segments 3 and 4 are reduced in phyl²/phyl⁴ flies. 58% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 9.2% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 6.7% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 11.6% show other defects. Homozygous clones in the notum lack most bristles and the few remaining ones have a four socket phenotype. 75% of the neurons and 50% of the sheath cells of the es organs are missing in phyl¹/phyl² embryos, although most es organs form. (Pi et al., 2001) Embryos derived from homozygous germline clones show defects dissimilar to those caused by defective tor signalling: head skeleton and filzkorper are abnormal. (Dickson et al., 1996) Ommatidia of phyl²/phyl⁴ flies contain only 5 photoreceptor cells, an R8 and four cells of the R1-6 class. Rare ommatidia have five R1-R6 cells. This phenotype is also seen in clones of phyl² cells. Missing receptor cells are transformed to cone cells. (Dickson et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference phyl²/phyl⁴ has visible phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has visible phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001)
Suppressed by
Statement Reference phyl²/phyl⁴ has visible phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has visible phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001)
NOT suppressed by
Statement Reference phyl² has visible \| somatic clone phenotype, non-suppressible by Scer\GAL4^Eq1/sens^Scer\UAS.cNa (Pi et al., 2004)
Enhancer of
Statement Reference phyl²/phyl[+] is an enhancer of visible phenotype of sina³/sina² (Pi et al., 2001)
Phenotype Manifest In
Enhanced by
Statement Reference phyl²/phyl⁴ has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & tormogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & tormogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & trichogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & trichogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & tormogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & tormogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & trichogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & trichogen cell \| supernumerary phenotype, enhanceable by ttk[+]/ttk^osn (Pi et al., 2001)
Suppressed by
Statement Reference phyl¹/phyl² has eo neuron \| embryonic stage phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & tormogen cell \| supernumerary phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & tormogen cell \| supernumerary phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & trichogen cell \| supernumerary phenotype, suppressible by ttk[+]/ttk^1e11 (Pi et al., 2001) phyl²/phyl⁴ has mesothoracic tergum & trichogen cell \| supernumerary phenotype, suppressible by ttk[+]/ttk^osn (Pi et al., 2001)
NOT suppressed by
Statement Reference phyl² has chaeta \| somatic clone phenotype, non-suppressible by Scer\GAL4^Eq1/sens^Scer\UAS.cNa (Pi et al., 2004)
Enhancer of
Statement Reference phyl²/phyl[+] is an enhancer of adult abdominal segment 3 & chaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of adult abdominal segment 3 & microchaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of adult abdominal segment 4 & chaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of adult abdominal segment 4 & microchaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of mesothoracic tergum & chaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of mesothoracic tergum & microchaeta phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of mesothoracic tergum & tormogen cell \| supernumerary phenotype of sina³/sina² (Pi et al., 2001) phyl²/phyl[+] is an enhancer of mesothoracic tergum & trichogen cell \| supernumerary phenotype of sina³/sina² (Pi et al., 2001) phyl² is an enhancer of eye phenotype of phl¹² (Dickson et al., 1996) phyl² is an enhancer of photoreceptor cell R1 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R2 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R3 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R4 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R5 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R6 phenotype of phl¹² (Dickson et al., 1995) phyl² is an enhancer of photoreceptor cell R7 phenotype of phl¹² (Dickson et al., 1995)
NOT Enhancer of
Statement Reference phyl¹/phyl² is a non-enhancer of sensory neuron \| supernumerary phenotype of ttk^osn (Pi et al., 2001)
Suppressor of
Statement Reference phyl² is a suppressor \| somatic clone of microchaeta \| supernumerary phenotype of N^l1N-ts1 (Pi et al., 2001) phyl² is a suppressor of eye phenotype of phl::tor^12D.sev (Dickson et al., 1996) phyl² is a suppressor of photoreceptor cell R7 phenotype of phl::tor^12D.hs.sev (Dickson et al., 1995)
NOT Suppressor of
Statement Reference phyl¹/phyl² is a non-suppressor of sensory neuron \| supernumerary phenotype of ttk^osn (Pi et al., 2001)
Other
Statement Reference phyl², sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype (Dickson et al., 1995)
Additional Comments
Genetic Interactions
Statement Reference phyl²/+ ; sinah¹/sinah¹ flies have no visible mutant phenotype. (Cooper, 2007) Expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^Eq1 fails to rescue external sensory organ formation in homozygous phyl² clones in the notum. (Pi et al., 2004) N^l1N-ts1 ; phyl¹/phyl² embryos show a reduction in the number of neurons in each abdominal hemisegment. (Pi et al., 2001) Dominantly suppresses the rough eye phenotype of phl::tor^12D.sev. (Dickson et al., 1996) Suppresses rough eye phenotype of phl::tor^12D.hs.sev, almost completely eliminating the extra R7 cells. Dominantly enhances the photoreceptor phenotype of phl¹² and 'sev³⁵¹'. (Dickson et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	phyl¹/phyl² is partially rescued by phyl^3.4.ORF (Pi et al., 2004) phyl¹/phyl² is partially rescued by phyl^4.1.ORF (Pi et al., 2004)
Not rescued by	phyl¹/phyl² is not rescued by phyl^3.4ΔE.ORF (Pi et al., 2004) phyl¹/phyl² is not rescued by phyl^3.4ΔES.ORF (Pi et al., 2004)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	phyl² Phyl² (Cooper, 2007) phyl^17L1 (Dickson et al., 1996)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Cooper, 2007, Mech. Dev. 124(7-8): 584--591 In vivo function of a novel Siah protein in Drosophila. [FBrf0200839] Pi et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101(22): 8378--8383 phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. [FBrf0179385] Artero et al., 2003, Development 130(25): 6257--6272 Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. [FBrf0167513] Pi et al., 2001, Development 128(14): 2699--2710 A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. [FBrf0138359] Li et al., 1997, Cell 90(3): 469--478 Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor tramtrack. [FBrf0098298] Dickson et al., 1996, Genetics 142(1): 163--171 Mutations modulating Raf signaling in Drosophila eye development. [FBrf0086382] Kauffmann et al., 1996, Genes Dev. 10(17): 2167--2178 Ras1 signaling and transcriptional competence in the R7 cell of Drosophila. [FBrf0089979] Dickson et al., 1995, Cell 80(3): 453--462 Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. [FBrf0079990]

Allele Dmel\phyl2

Allele Dmel\phyl²