FB2025_02 , released April 17, 2025
Allele: Dmel\phyl4
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General Information
Symbol
Dmel\phyl4
Species
D. melanogaster
Name
FlyBase ID
FBal0044262
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

adult abdominal segment 3 & chaeta (with phyl1)

adult abdominal segment 3 & chaeta (with phyl2)

adult abdominal segment 3 & microchaeta (with phyl1)

adult abdominal segment 3 & microchaeta (with phyl2)

adult abdominal segment 3 & tormogen cell | supernumerary (with phyl1)

adult abdominal segment 3 & tormogen cell | supernumerary (with phyl2)

adult abdominal segment 3 & trichogen cell | supernumerary (with phyl1)

adult abdominal segment 3 & trichogen cell | supernumerary (with phyl2)

adult abdominal segment 4 & chaeta (with phyl1)

adult abdominal segment 4 & chaeta (with phyl2)

adult abdominal segment 4 & microchaeta (with phyl1)

adult abdominal segment 4 & microchaeta (with phyl2)

adult abdominal segment 4 & tormogen cell | supernumerary (with phyl1)

adult abdominal segment 4 & tormogen cell | supernumerary (with phyl2)

adult abdominal segment 4 & trichogen cell | supernumerary (with phyl1)

adult abdominal segment 4 & trichogen cell | supernumerary (with phyl2)

mesothoracic tergum & chaeta (with phyl1)

mesothoracic tergum & chaeta (with phyl2)

mesothoracic tergum & microchaeta (with phyl1)

mesothoracic tergum & microchaeta (with phyl2)

mesothoracic tergum & tormogen cell | supernumerary (with phyl1)

mesothoracic tergum & tormogen cell | supernumerary (with phyl2)

mesothoracic tergum & trichogen cell | supernumerary (with phyl1)

mesothoracic tergum & trichogen cell | supernumerary (with phyl2)

Detailed Description
Statement
Reference

phyl4/phyl2245 flies have a greatly reduced number of bristles on the notum compared to wild type.

78% of the notal microchaetae and 87% of the microchaetae on abdominal segments 3 and 4 are missing in phyl1/phyl4 flies. 45% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 28% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 1% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 20% show other defects. The number of notal microchaetae and microchaetae on abdominal segments 3 and 4 are reduced in phyl2/phyl4 flies. 58% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 9.2% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 6.7% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 11.6% show other defects. phyl2245/phyl4 adults lack some bristles and other bristles are abnormal.

Semiviable in combination with phyl1, phyl2, phyl3, phyl5 and phyl6. Ommatidia of phyl2/phyl4 flies contain only 5 photoreceptor cells, an R8 and four cells of the R1-6 class. Rare ommatidia have five R1-R6 cells. Missing receptor cells are transformed to cone cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

phyl2/phyl4 has visible phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has visible phenotype, enhanceable by ttk[+]/ttkosn

Suppressed by
Statement
Reference

phyl2/phyl4 has visible phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has visible phenotype, suppressible by ttk[+]/ttkosn

Phenotype Manifest In
Enhanced by
Statement
Reference

phyl2/phyl4 has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

Suppressed by
Statement
Reference

phyl2/phyl4 has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttkosn

Enhancer of
Statement
Reference

phyl4 is an enhancer of photoreceptor cell R1 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R2 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R3 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R4 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R5 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R6 phenotype of Raf12

phyl4 is an enhancer of photoreceptor cell R7 phenotype of Raf12

Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Suppresses rough eye phenotype of phl::tor12D.hs.sev, almost completely eliminating the extra R7 cells. Dominantly enhances the photoreceptor phenotype of phl12 and 'sev351'.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

phyl4/phyl2245 is partially rescued by phyl3.4.ORF

phyl4/phyl2245 is partially rescued by phyl3.4ΔE.ORF

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)