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General Information
Symbol
Dmel\phylhs.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0044267
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sE-phyl
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

phyl cDNA is expressed under the transcriptional control of an Hsp70 promoter and one copy of the sev enhancer.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

phylhs.sev heterozygous mutants exhibit a rough eye phenotype. They exhibit an average of 1.71 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type.

14-3-3εS-696 does not show any dominant interaction with phylhs.sev.

Eyes are roughened. Ectopic R7 cells develop. Additional R7 cells is independent of sev activity but depends on sina function. Additional R7 cells are derived from cone cell precursors.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

phylhs.sev has phenotype, enhanceable by ttk1

NOT Enhanced by
Statement
Reference

phylhs.sev has eye phenotype, non-enhanceable by alphS-331

phylhs.sev has eye phenotype, non-enhanceable by alphS-355

Suppressed by
Statement
Reference

phylhs.sev has phenotype, suppressible by lilliXS407/lilliXS407

phylhs.sev has phenotype, suppressible by lillis35

phylhs.sev has phenotype, suppressible by lilliXS575

phylhs.sev has phenotype, suppressible by sina2

phylhs.sev has phenotype, suppressible by sina3

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

phylhs.sev heterozygous mutants in combination with alphS-331 exhibit a rough eye phenotype. They exhibit an average of 1.72 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phylhs.sev heterozygous mutants.

phylhs.sev heterozygous mutants in combination with alphS-355 exhibit a rough eye phenotype. They exhibit an average of 1.70 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phylhs.sev heterozygous mutants.

Not lethal in combination with sevS11.T:Hsap\MYC.

Flies carrying both phylhs.sev and ttk88.hs.sev.T:Hsap\MYC have more normal eyes than flies carrying either phylhs.sev or ttk88.hs.sev.T:Hsap\MYC alone. The phylhs.sev phenotype is weakly enhanced by ttk1/+.

Xenogenetic Interactions
Statement
Reference

Combination of phylhs.sev and Scer\GAL4hs.2sev-driven expression of Dl::NΔECN.Scer\UAS results in a significant rescue in the specification of R1 and R6 cell types.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
phylhs.sev
Name Synonyms
Secondary FlyBase IDs
    References (8)