Allele Dmel\phyl^hs.sev

General Information
Symbol	Dmel\phyl^hs.sev	Species	D. melanogaster
Name		FlyBase ID	FBal0044267
Feature type	allele	Associated gene	Dmel\phyl

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: phyl cDNA is expressed under the transcriptional control of an Hsp70 promoter and one copy of the sev enhancer. (Dickson et al., 1995)
Carried in construct	P{sev-phyl} (Nagaraj and Banerjee, 2009, Dickson et al., 1995, Tang et al., 2001, Maixner et al., 1998, Li et al., 1997, Tang et al., 1997, Chang and Rubin, 1997, Baril and Therrien, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Tang et al., 1997)
Phenotype Manifest In
	cone cell \| precursor (Dickson et al., 1995) eye (Tang et al., 1997, Dickson et al., 1995, Baril and Therrien, 2006) photoreceptor cell R1 (Nagaraj and Banerjee, 2009) photoreceptor cell R6 (Nagaraj and Banerjee, 2009) photoreceptor cell R7 (Dickson et al., 1995) photoreceptor cell R7 \| supernumerary (Baril and Therrien, 2006)
Detailed Description
	Statement Reference phyl^hs.sev heterozygous mutants exhibit a rough eye phenotype. They exhibit an average of 1.71 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. (Baril and Therrien, 2006) 14-3-3ε^S-696 does not show any dominant interaction with phyl^hs.sev. (Chang and Rubin, 1997) Eyes are roughened. Ectopic R7 cells develop. Additional R7 cells is independent of sev activity but depends on sina function. Additional R7 cells are derived from cone cell precursors. (Dickson et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference phyl^hs.sev, sev^{S11.T:Hsap\MYC} has viable phenotype (Maixner et al., 1998, Maixner et al., 1998) phyl^hs.sev, ttk^{88.hs.sev.T:Hsap\MYC} has visible phenotype (Tang et al., 1997, Tang et al., 1997)
Phenotype Manifest In
Enhanced by
Statement Reference phyl^hs.sev has phenotype, enhanceable by ttk¹ (Tang et al., 1997)
NOT Enhanced by
Statement Reference phyl^hs.sev has eye phenotype, non-enhanceable by alph^S-331 (Baril and Therrien, 2006) phyl^hs.sev has eye phenotype, non-enhanceable by alph^S-355 (Baril and Therrien, 2006)
Suppressed by
Statement Reference phyl^hs.sev has phenotype, suppressible by lilli^s35 (Tang et al., 2001) phyl^hs.sev has phenotype, suppressible by lilli^XS407 (Tang et al., 2001) phyl^hs.sev has phenotype, suppressible by lilli^XS575 (Tang et al., 2001) phyl^hs.sev has phenotype, suppressible by sina² (Tang et al., 1997) phyl^hs.sev has phenotype, suppressible by sina³ (Tang et al., 1997) phyl^hs.sev has photoreceptor cell R1 phenotype, suppressible by Dl::N^{ΔECN.Scer\UAS}/Scer\GAL4^hs.2sev (Nagaraj and Banerjee, 2009) phyl^hs.sev has photoreceptor cell R6 phenotype, suppressible by Dl::N^{ΔECN.Scer\UAS}/Scer\GAL4^hs.2sev (Nagaraj and Banerjee, 2009)
Other
Statement Reference phyl^hs.sev, ttk^{88.hs.sev.T:Hsap\MYC} has eye phenotype (Tang et al., 1997, Tang et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference phyl^hs.sev heterozygous mutants in combination with alph^S-331 exhibit a rough eye phenotype. They exhibit an average of 1.72 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phyl^hs.sev heterozygous mutants. phyl^hs.sev heterozygous mutants in combination with alph^S-355 exhibit a rough eye phenotype. They exhibit an average of 1.70 R7 cells per ommatidium, compared to 1 R7 cell per ommatidium in wild-type. This however is no higher than in phyl^hs.sev heterozygous mutants. (Baril and Therrien, 2006) Not lethal in combination with sev^{S11.T:Hsap\MYC}. (Maixner et al., 1998) Flies carrying both phyl^hs.sev and ttk^{88.hs.sev.T:Hsap\MYC} have more normal eyes than flies carrying either phyl^hs.sev or ttk^{88.hs.sev.T:Hsap\MYC} alone. The phyl^hs.sev phenotype is weakly enhanced by ttk¹/+. (Tang et al., 1997)
Xenogenetic Interactions
Statement Reference Combination of phyl[hs.sev] and Scer\GAL4[hs.2sev]-driven expression of Dl::N[ΔECN.Scer\UAS] results in a significant rescue in the specification of R1 and R6 cell types. (Nagaraj and Banerjee, 2009)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	phyl^hs.sev
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Nagaraj and Banerjee, 2009, EMBO J. 28(4): 337--346 Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. [FBrf0206749] Baril and Therrien, 2006, Dev. Biol. 294(1): 232--245 Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. [FBrf0190087] Tang et al., 2001, Development 128(5): 801--813 Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. [FBrf0134581] Maixner et al., 1998, Dev. Genet. 23(4): 347--361 A screen for mutations that prevent lethality caused by expression of activated Sevenless and Ras1 in the Drosophila embryo. [FBrf0105879] Chang and Rubin, 1997, Genes Dev. 11(9): 1132--1139 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila. [FBrf0093395] Li et al., 1997, Cell 90(3): 469--478 Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor tramtrack. [FBrf0098298] Tang et al., 1997, Cell 90(3): 459--467 PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. [FBrf0098364] Dickson et al., 1995, Cell 80(3): 453--462 Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. [FBrf0079990]

Allele Dmel\phylhs.sev

Allele Dmel\phyl^hs.sev