FlyBase Allele Report: Dmel\Syx1A[06737]

General Information

Symbol

Dmel\Syx1A⁰⁶⁷³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0044376

Feature type

allele

Associated gene

Dmel\Syx1A

Associated Insertion(s)

P{PZ}Syx1A⁰⁶⁷³⁷

Carried in Construct

Also Known As

P^syx

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wu et al., 1999, Schulze and Bellen, 1996, Schulze et al., 1995)

Mutagen

P-element activity

(Spradling et al., 1999, Wu et al., 1999, FlyBase, 1996-, Schulze and Bellen, 1996, Broadie et al., 1995, Schulze et al., 1995, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}Syx1A⁰⁶⁷³⁷

Cytology

Description

The P{PZ}Syx1A⁰⁶⁷³⁷ insertion maps within both Syx1A and 4EHP (nested genes).

(FlyBase, 1996-)

P-element insertion 880bp upstream of the translation start site.

(Schulze et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:24,105,300..24,105,300 [+]

(Bulgari et al., 2019, Spradling et al., 1999, Wu et al., 1999, FlyBase, 1996-, Schulze and Bellen, 1996, Broadie et al., 1995, Schulze et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle

(Perrimon et al., 1996)

neuromuscular junction | embryonic stage

(Schulze and Bellen, 1996)

ommatidium

(Schulze and Bellen, 1996)

somatic muscle cell

(Schulze et al., 1995)

wing

(Schulze and Bellen, 1996)

Detailed Description

Statement

Reference

Homozygous embryos do not exhibit cuticle defects. Germline clones produce eggs with poorly differentiated cuticle.

(Perrimon et al., 1996)

Mutation compromises neurotransmission at the embryonic neuromuscular junction. Mature embryos fail to exhibit contraction waves but do emerge from the egg case. Cuticular structures are normal. Syx1A⁰⁶⁷³⁷/Syx1A^15ts transheterozygotes give progeny that exhibit reduced viability, rough eyes (disrupted ommatidial array, ommatidia may be missing, fused, improperly rotated or misaligned) and notching along the posterior margin of the wing. Clones cannot be recovered in the eye as lack of Syx1A activity in cells of the developing eye causes lethality.

(Schulze and Bellen, 1996)

Embryos do not exhibit typical peristaltic construction waves and reduced movements of the mouth hooks and muscles in the head region. Embryos were also unable to clear their tracheal system of fluid. Endogenous transmission is blocked but spontaneous vesicle release continues. The ability of vesicles to fuse and release neurotransmitter in response to calcium ion stimulus is impaired, reflected by the severely reduced excitatory junction current.

(Schulze et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Syx1A⁰⁶⁷³⁷ is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

Syx1A⁰⁶⁷³⁷ is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Syx1A^15ts

(Schulze and Bellen, 1996)

Syx1A¹⁷⁷

(Schulze and Bellen, 1996)

Syx1A⁴

(Schulze and Bellen, 1996)

Partially complements

Syx1A²⁰⁴

(Schulze and Bellen, 1996)

Syx1A²⁸⁷

(Schulze and Bellen, 1996)

Rescued by

Syx1A⁰⁶⁷³⁷ is rescued by Syx1A^I212A

(Wu et al., 1999)

Syx1A⁰⁶⁷³⁷ is rescued by Syx1A^+t13.5

(Wu et al., 1999)

Syx1A⁰⁶⁷³⁷ is rescued by Syx1A^I236A

(Wu et al., 1999)

Syx1A⁰⁶⁷³⁷ is rescued by Syx1A^+t11

(Schulze and Bellen, 1996)

Syx1A⁰⁶⁷³⁷ is rescued by Syx1A^+t6

(Schulze and Bellen, 1996)

Partially rescued by

Syx1A⁰⁶⁷³⁷ is partially rescued by Syx1A^H3-C

(Wu et al., 1999)

Not rescued by

Syx1A⁰⁶⁷³⁷ is not rescued by Syx1A^H3-N

(Wu et al., 1999)

Comments

Lethality is rescued by one copy of the Syx1A^+t11 or Syx1A^+t6 constructs, rescued adults are viable, fertile and morphologically normal. Less than 10% Syx1A²⁸⁷/Syx1A⁰⁶⁷³⁷ and Syx1A²⁰⁴/Syx1A⁰⁶⁷³⁷ transheterozygous adults are viable.

(Schulze and Bellen, 1996)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11697

ry⁵⁰⁶ P{PZ}Syx1A⁰⁶⁷³⁷ eIF4EHP⁰⁶⁷³⁷/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Lethality can be reverted by precise excision of the P-element.

(Schulze et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

06737

(Kaltenbach et al., 2007)

P^syx

(Broadie et al., 1995, Schulze et al., 1995)

Syx1A⁰⁶⁷³⁷

(Bulgari et al., 2019)

l(3)06737

(Spradling et al., 1999)

l(3)06737⁰⁶⁷³⁷

syx1A⁰⁶⁷³⁷

(Perrimon et al., 1996, BDGP Project Members, 1994-1999)

syx1A^P

syx⁰⁶⁷³⁷

(Stewart et al., 2001)

syx^P1697

(Wu et al., 1999)

syx^P

(Schulze and Bellen, 1996)

Name Synonyms

Secondary FlyBase IDs

FBal0009575

References (13)

Report Sections

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