Allele Dmel\w^unspecified

General Information
Symbol	Dmel\w^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0044450
Feature type	allele	Associated gene	Dmel\w
Also Known As	unspecified, w^-

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective (Zhou et al., 2008) eye color defective (Cheli et al., 2010)
Phenotype Manifest In

Detailed Description
	Statement Reference Mutant flies have white eyes. (Cheli et al., 2010) Mutant adults are defective in aggression, as evidenced by lengthened fighting latency and reduced frequency of lunging and high-intensity fighting (holding, boxing and tussling) when two flies are placed in a small closed chamber containing a food pad in the centre. When mutant flies are paired with wild-type flies in the aggression assay, fights are initiated and won more by the wild-type flies than by the mutant flies. (Zhou et al., 2008) The spectral sensitivity curve of the whole eye in the visible range is significantly narrower than the absorption spectrum of the template visual pigments. (Gribakin and Ukhanov, 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference w^unspecified/w^unspecified is an enhancer of lethal \| pupal stage phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, th^{dsRNA.Scer\UAS.cLa} (Mallik and Lakhotia, 2009, Mallik and Lakhotia, 2009)
Suppressor of
Statement Reference w^unspecified is a suppressor of courtship behavior defective \| male phenotype of blos1^ex2 (Cheli et al., 2010)
Phenotype Manifest In
Enhancer of
Statement Reference w^unspecified/w^unspecified is an enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, th^{dsRNA.Scer\UAS.cLa} (Mallik and Lakhotia, 2009, Mallik and Lakhotia, 2009)
Additional Comments
Genetic Interactions
Statement Reference The increased male-to-male courtship behaviour of blos1[ex2] males is suppressed by w[unspecified]. (Cheli et al., 2010) Scer\GAL4[GMR.PF]-mediated expression of th[dsRNA.Scer\UAS.cLa] results in a more severe eye phenotype and increased pupal lethality in a homozygous w[unspecified] background compared to a w[unspecified]/+ background. (Mallik and Lakhotia, 2009) Sce^D1 enhances the z-w interaction. (Gildea et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	w^sp1 (Lefevre and Wilkins, 1966)
Rescued by	w^unspecified is rescued by w^GMR.PT (Tomlinson, 2012) w^unspecified is rescued by w^Scer\UAS.cTa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Cheli et al., 2010)
Comments	w[GMR.PT] restores all eye pigmentation in a w[unspecified] fly, including the subretinal pigment. (Tomlinson, 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	The distribution of ry protein in the tissues of the adult fly is altered in this mutant. (Reaume et al., 1991) Turnover of the photoreceptor membrane in w^unspecified mutant flies has been studied using electron microscopy. (Sapp et al., 1991)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	unspecified (Ramos-Morales and Gonzalez, 1996, Gribakin and Ukhanov, 1990, Sapp et al., 1991, Reaume et al., 1991) w (Mallik and Lakhotia, 2009) w⁰ (Tomlinson, 2012) w^- (Mallik and Lakhotia, 2009, Nilsson et al., 2000) w^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 19 )
Research paper	Tomlinson, 2012, J. Comp. Neurol. 520(12): 2676--2682 The origin of the Drosophila subretinal pigment layer. [FBrf0218541] Cheli et al., 2010, Hum. Mol. Genet. 19(5): 861--878 Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. [FBrf0209903] Mallik and Lakhotia, 2009, Genetics 183(3): 831--852 The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila. [FBrf0209343] Zhou et al., 2008, Nat. Neurosci. 11(9): 1059--1067 A subset of octopaminergic neurons are important for Drosophila aggression. [FBrf0210476] Gildea et al., 2000, Genetics 156(2): 645--663 A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. [FBrf0129826] Nilsson et al., 2000, J. Neurogenet. 13(4): 213--232 Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. [FBrf0128591] Reichhart and Ferrandon, 1998, D. I. S. 81: 201--202 Green balancers. [FBrf0105466] Rodrigues-Arnaiz, 1997, Mutat. Res. 395(2-3): 229--242 Genotoxic activation of hydrazine, two dialkylhydrazines, thiourea and ethylene thiourea in the somatic w/w⁺ assay of Drosophila melanogaster. [FBrf0100625] Hidalgo et al., 1995, Development 121(11): 3703--3712 Targeted ablation of glia disrupts axon tract formation in the Drosophila CNS. [FBrf0084024] Reaume et al., 1991, Genetics 129: 1099--1109 The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments. [FBrf0054121] Sapp et al., 1991, J. Neurocytol. 20(7): 597--608 Turnover of membrane and opsin in visual receptors of normal and mutant Drosophila. [FBrf0054498] Sierra et al., 1991, Mutat. Res. 260(1-2): 247--256 Acrolein genotoxicity in Drosophila melanogaster. [FBrf0054745] Szakmary and Knasmuller, 1991, Mutagenesis 6: 225--228 Effects of tannic acid on spontaneous and induced somatic mutations in Drosophila melanogaster. [FBrf0054728] Gribakin and Ukhanov, 1990, J. Comp. Physiol. A, Sens. Neural. Behav. Physiol. 167(5): 715--721 Is the white eye of insect eye-color mutants really white? [FBrf0063493] Lechien et al., 1990, Genetica 80(3): 189--194 Rare male advantage and sex ratio. [FBrf0051892] Lefevre and Wilkins, 1966, Genetics 53(1): 175--187 Cytogenetic studies on the white locus in Drosophila melanogaster. [FBrf0017789]
Supplementary material	Cheli et al., 2010, Hum. Mol. Genet. 19(5): Supplementary Data. [FBrf0210495]
Abstract	Ramos-Morales and Gonzalez, 1996, Environ. Molec. Mutagen. 27(Suppl. 27): 55 Sodium azide genotoxicity after chronic treatment of Drosophila melanogaster larvae: Gender and genetic dowry differences. [FBrf0087666] Vogel, 1991, Mutat. Res. 252: 169 The future of SMART assays: emphasis on the underlying action principles? [FBrf0066202]

Allele Dmel\wunspecified

Allele Dmel\w^unspecified