Allele Dmel\wts^P1

General Information
Symbol	Dmel\wts^P1	Species	D. melanogaster
Name		FlyBase ID	FBal0044485
Feature type	allele	Associated gene	Dmel\wts
Also Known As	lats^P1

Allele class	hypomorphic allele - genetic evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Mikeladze-Dvali et al., 2005, Emoto et al., 2006)
Mutagen	Delta2-3 (Justice et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{lacW}wts^P509-19 (Justice et al., 1995)
Nature of the lesion	Statement Reference Deletion of DNA flanking the wts^P509-19 P{lacW} insertion, probably in the proximal direction, without loss of the distal P{lacW} sequences. (Justice et al., 1995)
Caused by insertion	P{lacW}wts^P1 (Justice et al., 1995, Stewart et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell number \| larval stage (Cho et al., 2006) lethal \| recessive (Justice et al., 1995) neuroanatomy defective (Emoto et al., 2006) tumorigenic (Justice et al., 1995) visible \| recessive (Das Thakur et al., 2010)
Phenotype Manifest In
	dorsal multidendritic neuron ddaC \| somatic clone (Emoto et al., 2006) eye (Das Thakur et al., 2010) photoreceptor cell R8 of pale ommatidium \| supernumerary (Mikeladze-Dvali et al., 2005) photoreceptor cell R8 of yellow ommatidium (Mikeladze-Dvali et al., 2005) rhabdomere R8 (Mikeladze-Dvali et al., 2005) wing disc \| larval stage (Cho et al., 2006)
Detailed Description
	Statement Reference wts[P1] mutants produce overgrown adult eyes. (Das Thakur et al., 2010) The total number of photoreceptors, as well as the number of Rh5-positive and Rh6-positive photoreceptors is normal in the eyes of homozygous larvae. (Sprecher et al., 2007) Overgrowth is seen wts[P1] mutant wing discs collected 36-48 hours after the L2-L3 molt. (Cho et al., 2006) In wts[P1] mutants, ddaC dendrites are indistinguishable from wild-type controls at 24-28 hours after egg-laying. By 48-52 hours after egg laying, wts[P1] mutant dendrites tile the body wall as in wild-type. During the following 24 hours, however, wts[P1] dendrites disappear from the body wall, implying wts is required for maintenance of the already established tiling of dendrites. (Emoto et al., 2006) wts^P1 eyes are missing yR8 photoreceptor cells and contain an expansion of the pR8 subset. Some R8 rhabdomeres are missing altogether in these eyes but this cannot account for the complete absence of yR8 cells. (Mikeladze-Dvali et al., 2005) Homozygotes exhibit embryonic or early larval lethality. wts tumour phenotype in mitotic clones: overproliferation and apical hypertrophy of epithelial cells leading to abnormal deposition of cuticle. (Justice et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference wts^P1 has increased cell number \| larval stage phenotype, non-suppressible by d¹ (Cho et al., 2006)
NOT Enhancer of
Statement Reference wts^P1/wts[+] is a non-enhancer of visible phenotype of CycE^JP (Brumby et al., 2004)
NOT Suppressor of
Statement Reference wts^P1/wts[+] is a non-suppressor of visible phenotype of CycE^JP (Brumby et al., 2004)
Other
Statement Reference Df(1)jub^I, wts^P1 has visible \| recessive phenotype (Das Thakur et al., 2010)
Phenotype Manifest In
NOT Enhanced by
Statement Reference wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-enhanceable by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-enhanceable by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-enhanceable by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-enhanceable by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005)
NOT suppressed by
Statement Reference wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-suppressible by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-suppressible by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of pale ommatidium \| supernumerary phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-suppressible by Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-suppressible by sev¹⁴ (Mikeladze-Dvali et al., 2005) wts^P1 has rhabdomere R8 phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3 (Mikeladze-Dvali et al., 2005) wts^P1 has wing disc \| larval stage phenotype, non-suppressible by d¹ (Cho et al., 2006)
NOT Enhancer of
Statement Reference wts^P1/wts[+] is a non-enhancer of eye phenotype of CycE^JP (Brumby et al., 2004)
NOT Suppressor of
Statement Reference wts^P1/wts[+] is a non-suppressor of eye phenotype of CycE^JP (Brumby et al., 2004)
Other
Statement Reference Df(1)jub^I, wts^P1 has eye phenotype (Das Thakur et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference A Df(1)djub[I]/+ genetic background modestly affects the wts[P1] eye phenotypes. (Das Thakur et al., 2010) d[GC13] does not suppress the wing disc overgrowth seen in wts[P1] mutant larvae. (Cho et al., 2006) sev¹⁴; wts^P1 double-mutant retina show the same phenotype as wts^P1 eyes, with all R8 cells being specified as the p subtype. Df(3L)melt-Δ3, wts^P1 double mutants and sev¹⁴; Df(3L)melt-Δ3, wts^P1 triple mutants also show the wts^P1 phenotype. (Mikeladze-Dvali et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	wts^P1 is rescued by wts^{Scer\UAS.L.T:Hsap\MYC}/Scer\GAL4^ppk.PG (Emoto et al., 2006)
Not rescued by	wts^P1 is not rescued by wts^{S920.T1083.Scer\UAS}/Scer\GAL4^ppk.PG (Emoto et al., 2006)
Comments	Expression of wts[Scer\UAS.L.T:Hsap\MYC], under the control of Scer\GAL4[ppk.PG] largely rescues the dendritic phenotype of wts[P1]. Expression of wts[S920.T1083.Scer\UAS] under the control of Scer\GAL4[ppk.PG] fails to rescue the dendritic phenotypes associated with wts[P1] mutants. (Emoto et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	lats^P1 (Brumby et al., 2004, Tao et al., 1999) wts^latsP1 (Mikeladze-Dvali et al., 2005) wts^P1 (Sprecher et al., 2007, Emoto et al., 2006, Cho et al., 2006) wts^p1 (Das Thakur et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Das Thakur et al., 2010, Curr. Biol. 20(7): 657--662 Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. [FBrf0210592] Sprecher et al., 2007, Genes Dev. 21(17): 2182--2195 Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. [FBrf0205916] Cho et al., 2006, Nat. Genet. 38(10): 1142--1150 Delineation of a Fat tumor suppressor pathway. [FBrf0193283] Emoto et al., 2006, Nature 443(7108): 210--213 The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. [FBrf0195286] Mikeladze-Dvali et al., 2005, Cell 122(5): 775--787 The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. [FBrf0187233] Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Stewart et al., 2003, Oncogene 22(41): 6436--6444 A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. [FBrf0162272] Tao et al., 1999, Nat. Genet. 21(2): 177--181 Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. [FBrf0107344] Justice et al., 1995, Genes Dev. 9(5): 534--546 The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. [FBrf0080138] Xu et al., 1995, Development 121(4): 1053--1063 Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. [FBrf0079656]

Allele Dmel\wtsP1

Allele Dmel\wts^P1