Allele Dmel\wts^x1

General Information
Symbol	Dmel\wts^x1	Species	D. melanogaster
Name		FlyBase ID	FBal0044527
Feature type	allele	Associated gene	Dmel\wts
Also Known As	lats^X1, wts^latsX1

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Xu et al., 1995) loss of function allele (Bennett and Harvey, 2006, Willecke et al., 2006, Emoto et al., 2006)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell death \| somatic clone (Tapon et al., 2002) increased cell number \| somatic clone (Ren et al., 2010) lethal \| pupal stage \| somatic clone (Wu et al., 2003, Badouel et al., 2009, Zhang et al., 2011) lethal \| recessive (Xu et al., 1995) lethal \| somatic clone \| third instar larval stage (Zhang et al., 2011) mitotic cell cycle defective \| somatic clone (Ren et al., 2010) neoplasia \| somatic clone (Zhang et al., 2011) neuroanatomy defective (Emoto et al., 2006, Wen et al., 2011) size defective \| somatic clone \| third instar larval stage (Badouel et al., 2009) stress response defective \| somatic clone (Colombani et al., 2006) tumorigenic (Busygina et al., 2004) visible \| recessive (Hamaratoglu et al., 2006) visible \| somatic clone (Zhang et al., 2008)
Phenotype Manifest In
	cell cycle \| somatic clone (Tapon et al., 2002) class IV dendritic arborizing neuron (Wen et al., 2011) dendrite (Wen et al., 2011) dorsal multidendritic neuron ddaC \| somatic clone & dendritic tree (Emoto et al., 2006) eye (Hamaratoglu et al., 2006) eye \| somatic clone (Zhang et al., 2008, Zhang et al., 2011) eye disc \| somatic clone (Menut et al., 2007, Neto-Silva et al., 2010, Badouel et al., 2009, Zhang et al., 2011) inter-ommatidial cell \| pupal stage \| supernumerary (Hamaratoglu et al., 2006) intestinal stem cell \| somatic clone (Ren et al., 2010) morphogenetic furrow \| somatic clone (Zhang et al., 2011) ommatidial precursor cluster \| somatic clone (Zhang et al., 2011) pigment cell \| ectopic (Tapon et al., 2002) wing disc \| somatic clone (Genevet et al., 2009, Neto-Silva et al., 2010)
Detailed Description
	Statement Reference Cells in homozygous clones in the wing disc accumulate F-actin near the apical surface. (Fernández et al., 2011) wts[x1] mutants show a progressive loss of dendritic branches in class IV neurons without affecting axons. (Wen et al., 2011) Clones of tissue harbouring wts[x1] generated in the eye using the eyFlp/MARCM system overgrow dramatically and cause lethality at late third instar larval or early pupal stages of development. Eye discs substantially over-grow when wts[x1] clones are generated using eyFlp/MARCM, with wts[x1] clones occupying almost the entire eye disc. Very few presumptive ommatidial clusters are observed and there is no obvious sign of the morphogenetic furrow. (Zhang et al., 2011) wts[x1] mutant cell clones display a large size and occupy large territories of wing and eye discs. (Neto-Silva et al., 2010) wts[x1] mutant MARCM clones contain 5-7 cells per clone, compared to 2-3 cells in wild-type clones. These clones contain differentiated absorptive enterocytes and secretory enteroendocrine cells indicating that intestine stem cell differentiation continues as in wild-type. (Ren et al., 2010) Induction of wts[x1] clones in third instar larval eye discs (generated using the eyFLP technique) results in massive overgrowth, with mutant cells covering almost the entire eye disc. The discs appear deformed with a folded excessive epithelium. No animals progress beyond the pupal stage. (Badouel et al., 2009) Homozygous clones in the wing disc have a growth advantage; the ratio of mutant clone area: area of the wild-type twin spot is 2.93. (Genevet et al., 2009) wts[x1] homozygous mutant clones generated in the male germline develop normally. 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells. (Sun et al., 2008) Adult eyes carrying homozygous mutant clones are overgrown. (Zhang et al., 2008) Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation. Neuronal differentiation is strongly impaired in these eye discs. (Menut et al., 2007) Heterozygous larvae show no significant defects in dendrite morphology of ddaC neurons. Heterozygous males do not have ectopic sex combs on the second or third legs. (Parrish et al., 2007) Eye and wing imaginal discs heterozygous for wts^x1 are normal in size and morphology and are indistinguishable from wild-type discs. (Bennett and Harvey, 2006) Apoptosis is reduced by up to 3-fold in wts^x1 clones of wing or eye discs in response to γ-rays compared to wild-type tissue. (Colombani et al., 2006) Compared to wild-type ddaC (dorsal dendrite arborization neuron C) neurons, wts[x1] MARCM clones exhibit a severe and highly penetrant simplification of dendritic trees, with a significantly reduced number and length of dendritic branches, and hence a greatly reduced dendritic field. In contrast to the severe dendritic defects caused by loss of wts function, wts[x1] MARCM clones of ddaC axons enter the ventral nerve cord at the appropriate position and show arborization patterns very similar to wild-type controls, with their axons terminating on the innermost fascicle and sending ipsilateral branches anteriorly and posteriorly and sometimes also a collateral branch towards the midline. wts[x1] heterozygotes do not exhibit an obvious dendritic phenotype. (Emoto et al., 2006) The mid-pupal retina of wts[x1]/wts[x1] animals contains a large excess of inter-ommatidial cells. The resulting adult eyes are distorted and lumpy. (Hamaratoglu et al., 2006) wts^x1 adults show tumor formation at extremely high penetrance. Each tumor represents a separate event as the tumors do not metastasize. (Busygina et al., 2004) Mutant clones in the eye disc result in noninvasive tumours that never move from the head region. (Pagliarini and Xu, 2003) When somatic clones of wts^x1 homozygous cells are generated throughout the eye disc using Scer\FLP1^ey.PN, none resulting animals survive to eclosion. (Wu et al., 2003) When wts^x1 clones are made in the developing eye more cell divisions are seen than in wild-type cells. Also the normal cell death that occurs in the retina is almost completely abolished. (Tapon et al., 2002) Lethal period is late embryonic and first larval instar. Mutant clones induced in first larval instar can be as large as 1/5 of the body size. (Xu et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference wts^x1 has neuroanatomy defective phenotype, non-enhanceable by sav³ (Emoto et al., 2006)
Suppressed by
Statement Reference wts^x1 has lethal \| somatic clone \| pupal stage phenotype, suppressible \| partially by ex^{CT.Scer\UAS.P\T.T:Avic\GFP-EGFP}/Scer\GAL4^tub.PU (Badouel et al., 2009) wts^x1 has lethal \| somatic clone \| pupal stage phenotype, suppressible \| partially by ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP}/Scer\GAL4^tub.PU (Badouel et al., 2009) wts^x1 has lethal \| somatic clone phenotype, suppressible by Wbp2^GD7170/Scer\GAL4^αTub84B.PL (Zhang et al., 2011) wts^x1 has lethal \| somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL (Zhang et al., 2011) wts^x1 has neoplasia \| somatic clone phenotype, suppressible by Wbp2^GD7170/Scer\GAL4^αTub84B.PL (Zhang et al., 2011) wts^x1 has neuroanatomy defective phenotype, suppressible by Nmnat^Δ4790-2 (Wen et al., 2011) wts^x1 has neuroanatomy defective phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^Scer\UAS.cZa (Wen et al., 2011) wts^x1 has size defective \| somatic clone \| third instar larval stage phenotype, suppressible \| partially by ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP}/Scer\GAL4^tub.PU (Badouel et al., 2009) wts^x1 has tumorigenic phenotype, suppressible by Hsap\LATS1^hs.PT (Tao et al., 1999) wts^x1 has visible \| somatic clone phenotype, suppressible by sd^{dsRNA.C.Scer\UAS}/Scer\GAL4^tub.PU/sd^{dsRNA.N.Scer\UAS} (Zhang et al., 2008)
NOT suppressed by
Statement Reference wts^x1 has lethal \| somatic clone \| pupal stage phenotype, non-suppressible by Scer\GAL4^tub.PU/ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Badouel et al., 2009) wts^x1 has size defective \| somatic clone \| third instar larval stage phenotype, non-suppressible by Scer\GAL4^tub.PU/ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Badouel et al., 2009)
Enhancer of
Statement Reference wts^x1/wts[+] is an enhancer of hyperplasia \| recessive phenotype of ex^AP49 (Hamaratoglu et al., 2006) wts^x1/wts[+] is an enhancer of partially lethal - majority die phenotype of hpo^+t4.0, hpo^42-20 (Wu et al., 2003) wts^x1/wts[+] is an enhancer of visible \| dominant phenotype of Pc¹ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of visible \| dominant phenotype of Pc³ (Parrish et al., 2007)
NOT Enhancer of
Statement Reference wts^x1/wts[+] is a non-enhancer of neuroanatomy defective phenotype of hpo^MGH4 (Emoto et al., 2006) wts^x1 is a non-enhancer of tumorigenic \| somatic clone phenotype of mats^e235 (Lai et al., 2005)
Suppressor of
Statement Reference wts^x1/wts[+] is a suppressor \| partially of increased cell death phenotype of Scer\GAL4^C5/Scer\GAL4^C5, hpo^Scer\UAS.cUa (Udan et al., 2003) wts^x1/wts^x1 is a suppressor \| partially of increased cell death \| third instar larval stage phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ex^Scer\UAS.cBa (Hamaratoglu et al., 2006, Hamaratoglu et al., 2006) wts^x1 is a suppressor \| partially of increased cell death phenotype of p53^GMR.Ex (Colombani et al., 2006) wts^x1 is a suppressor of decreased cell number \| somatic clone \| larval stage phenotype of Scer\GAL4^{Scer\FRT.Act5C}, ex^Scer\UAS.cBa (Cho et al., 2006)
NOT Suppressor of
Statement Reference wts^x1 is a non-suppressor of tumorigenic \| somatic clone phenotype of mats^e235 (Lai et al., 2005)
Other
Statement Reference Fancd2^{dsRNA.Scer\UAS}, Scer\GAL4^ey.PU, wts^x1/wts[+] has chemical sensitive phenotype (Marek and Bale, 2006, Marek et al., 2008) Fancd2^{dsRNA.Scer\UAS}, Scer\GAL4^ey.PU, wts^x1/wts[+] has tumorigenic \| conditional phenotype (Marek and Bale, 2006, Marek et al., 2008) Fancd2^{dsRNA.Scer\UAS}, Scer\GAL4^ey.PU, wts^x1/wts[+] has visible \| chemical conditional phenotype (Marek and Bale, 2006, Marek et al., 2008) mei-41^unspecified, wts^x1 has tumorigenic phenotype (Busygina et al., 2004) Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has chemical sensitive phenotype (Marek et al., 2008) Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has tumorigenic \| conditional phenotype (Marek et al., 2008) Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has visible \| chemical conditional phenotype (Marek et al., 2008) Pc³, wts^x1/wts[+] has neuroanatomy defective \| dominant \| somatic clone phenotype (Parrish et al., 2007) sav³, wts^x1/wts[+] has neuroanatomy defective phenotype (Emoto et al., 2006)
Phenotype Manifest In
NOT Enhanced by
Statement Reference wts^x1 has dorsal multidendritic neuron ddaC \| somatic clone & dendritic tree phenotype, non-enhanceable by sav³ (Emoto et al., 2006)
Suppressed by
Statement Reference wts^x1 has class IV dendritic arborizing neuron phenotype, suppressible by Nmnat^Δ4790-2 (Wen et al., 2011) wts^x1 has class IV dendritic arborizing neuron phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^Scer\UAS.cZa (Wen et al., 2011) wts^x1 has dendrite phenotype, suppressible by Nmnat^Δ4790-2 (Wen et al., 2011) wts^x1 has dendrite phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^Scer\UAS.cZa (Wen et al., 2011) wts^x1 has eye \| somatic clone phenotype, suppressible by sd^{dsRNA.C.Scer\UAS}/Scer\GAL4^tub.PU/sd^{dsRNA.N.Scer\UAS} (Zhang et al., 2008) wts^x1 has eye disc \| somatic clone phenotype, suppressible \| partially by ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP}/Scer\GAL4^tub.PU (Badouel et al., 2009) wts^x1 has eye disc \| somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL (Zhang et al., 2011) wts^x1 has morphogenetic furrow \| somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL (Zhang et al., 2011) wts^x1 has ommatidial precursor cluster \| somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL (Zhang et al., 2011)
NOT suppressed by
Statement Reference wts^x1 has eye disc \| somatic clone phenotype, non-suppressible by Scer\GAL4^tub.PU/ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} (Badouel et al., 2009) wts^x1 has wing disc \| somatic clone phenotype, non-suppressible by crb^11A22 (Genevet et al., 2009)
Enhancer of
Statement Reference wts^x1/wts[+] is an enhancer of mesothoracic leg phenotype of Pc¹ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of mesothoracic leg phenotype of Pc³ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of metathoracic leg phenotype of Pc¹ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of metathoracic leg phenotype of Pc³ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of sex comb \| ectopic phenotype of Pc¹ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of sex comb \| ectopic phenotype of Pc³ (Parrish et al., 2007) wts^x1/wts[+] is an enhancer of wing disc phenotype of ex^AP49 (Hamaratoglu et al., 2006)
NOT Enhancer of
Statement Reference wts^x1/wts[+] is a non-enhancer of multidendritic dendrite phenotype of hpo^MGH4 (Emoto et al., 2006)
Suppressor of
Statement Reference wts^x1/wts[+] is a suppressor \| partially of wing phenotype of Scer\GAL4^C5/Scer\GAL4^C5, hpo^Scer\UAS.cUa (Udan et al., 2003) wts^x1/wts[+] is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, ft^{ΔECD.Scer\UAS} (Willecke et al., 2006) wts^x1/wts^x1 is a suppressor \| partially of eye disc \| third instar larval stage phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ex^Scer\UAS.cBa (Hamaratoglu et al., 2006, Hamaratoglu et al., 2006) wts^x1/wts^x1 is a suppressor of inter-ommatidial cell \| pupal stage phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ex^Scer\UAS.cBa (Hamaratoglu et al., 2006, Hamaratoglu et al., 2006) wts^x1/wts^x1 is a suppressor of inter-ommatidial cell \| pupal stage phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hpo^Scer\UAS.cUa (Hamaratoglu et al., 2006, Hamaratoglu et al., 2006) wts^x1 is a suppressor of wing disc \| somatic clone \| larval stage phenotype of Scer\GAL4^{Scer\FRT.Act5C}, ex^Scer\UAS.cBa (Cho et al., 2006)
Other
Statement Reference Fancd2^{dsRNA.Scer\UAS}, Scer\GAL4^ey.PU, wts^x1/wts[+] has eye \| chemical conditional phenotype (Marek and Bale, 2006, Marek et al., 2008) Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has eye \| chemical conditional phenotype (Marek et al., 2008) Pc³, wts^x1/wts[+] has dendrite & dorsal multidendritic neuron ddaC \| somatic clone phenotype (Parrish et al., 2007) sav³, wts^x1/wts[+] has dorsal multidendritic neuron ddaC \| somatic clone & dendritic tree phenotype (Emoto et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference Whereas wts[x1] ddaC MARCM clones show a simplifed dendritic arbor with significantly reduced numbers of terminal branches, wts[x1] clones overexpressing Nmnat[Scer\UAS.cZa] under the control of Scer\GAL4[elav-C155] elaborate dendrites with terminal branch numbers that do not differ statistically from wild-type controls. A similar rescue is seen in class IV neurons. A transheterozygous combination of Nmnat[Δ4790-2] and wts[x1] does not show any synthetic phenotypes in affecting axon or dendrite development of class IV neurons. (Wen et al., 2011) When Wbp2[KK108304] or Wbp2[GD7170] is expressed in wts[x1]-deficient tissues using eyFlp/MARCM, a significant increase in survival is observed with the majority of flies now reaching late pupal stages and forming pharate adults, with a small number emerging as fully developed adults. When Wbp2[KK108304] or Wbp2[GD7170] is expressed in wts[x1]-deficient tissues using eyFlp/MARCM, eye disc size is reduced, the amount of wts[x1] tissue relative to wild type tissue is decreased, and the differentiation of the developing eye is almost completely restored. (Zhang et al., 2011) Expression of ex[Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[tub.PU] largely suppresses the overgrowth phenotype seen in wts[x1] larval eye disc clones. The eye discs are no longer drastically deformed and retain a more normal shape. The pupal stage lethality is also partially rescued. Expression of ex[CT.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[tub.PU] partially suppresses the pupal stage lethality seen following the induction of wts[x1] larval eye disc clones. Expression of ex[linker.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[tub.PU] is unable to suppress the overgrowth phenotype seen in wts[x1] larval eye disc clones. The pupal stage lethality is also not rescued. (Badouel et al., 2009) The growth advantage of wts[x1] clones in the wing disc over their wild-type twin spots is not affected if the clones are also homozygous for crb[2]. (Genevet et al., 2009) Expression of Fancd2[dsRNA.Scer\UAS] in the eyes under the control of Scer\GAL4[ey.PU] enhances the rate of eye tumor formation in wts[x1]/+ mutant flies treated with nitrogen mustard. A Mnn1[e200] mutant background enhances the rate of eye tumor formation in response to nitrogen mustard compared to wts[x1]/+ mutant controls. (Marek et al., 2008) The eye overgrowth phenotype caused by wts[x1] clones is almost completely suppressed by co-expression of sd[dsRNA.N.Scer\UAS] and sd[dsRNA.C.Scer\UAS] under the control of Scer\GAL4[tub]. (Zhang et al., 2008) Pc[3]/wts[x1] double heterozygous larvae show dendritic defects in ddaC neurons; there is a significant reduction in the number of dendritic branchpoints. The ectopic sex comb phenotype seen on the second and third legs of Pc[3]/+ males is enhanced by wts[x1]. The ectopic sex comb phenotype seen on the second and third legs of Pc[1]/+ males is enhanced by wts[x1]/+. (Parrish et al., 2007) ft⁸/ft⁴²² mutants, heterozygous for wts^x1 exhibit a significant increase in size, both from wild-type and the ft⁸/ft⁴²² double mutant, and display an even more 'rippled' morphology. (Bennett and Harvey, 2006) A wts[x1] mutant background allows recovery of larval wing disc clones expressing ex[Scer\UAS.cBa] under the control of Scer\GAL4[Scer\FRT.Act5C]. (Cho et al., 2006) The p53^GMR.Ex-mediated induction of apoptosis in the posterior portion of late larval eye discs is reduced in wts^x1 clones. (Colombani et al., 2006) sav[3]/wts[x1] transheterozygotes exhibit simplified dendrites similar to moderately affected sav[3] MARCM clones. These double mutants show a severe dendrite effect comparable to wts[x1] MARCM clones. Transheterozygotes for wts[x1]/hpo[MGH4] display simplified dendrites similar to wts[x1] mutants. Transheterozygotes for wts[x1]/trc[1] do not show any significant dendritic phenotypes. (Emoto et al., 2006) Wing disc overgrowth seen in ex^AP49 homozygous late third instar larvae is enhanced by wts^x1/+. (Hamaratoglu et al., 2006) The loss of inter-ommatidial cells in the developing retinas of ex[Scer\UAS.cBa]; Scer\GAL4[GMR.PF] animals at the mid-pupal stage is completely suppressed in wts[x1]/wts[x1] somatic clones. The resulting clones have an excess of inter-ommatidial cells as do wts[x1]/wts[x1] somatic clones do. Heterozygosity for wts[x1] partially suppresses the reduction in size and patterning defects seen in the eyes of ex[Scer\UAS.cBa]; Scer\GAL4[GMR.PF] animals. The adult eye phenotype and the loss of interommmatidial cells seen in hpo[Scer\UAS.cUa]; Scer\GAL4[GMR.PF] mid-pupal retinas is suppressed by wts[x1]/wts[x1]. (Hamaratoglu et al., 2006) Overexpression of Akt1[Scer\UAS.T:Ivir\HA1] (under the control of Scer\GAL4[Act5C.PI]) using the FLP/FRT system in brain somatic clones mutant for scrib[1] and wts[x1] does not cause metastatic behaviour despite accelerated tumour growth. (Igaki et al., 2006) Expression of Fancd2[dsRNA.Scer\UAS] in the eyes under the control of Scer\GAL4[ey.PU] in a wts[x1]/+ mutant background does not enhance the rate of eye tumor formation compared to controls in normal conditions. However the number of eye tumors is significantly increased when flies are treated with either nitrogen mustard or cisplatinum. This increase is restricted to eye tumors; the rate of tumours in other anatomical locations is similar to controls. (Marek and Bale, 2006) The ft[ΔECD.Scer\UAS] phenotype (under the control of Scer\GAL4[nub-AC-62]) is suppressed by wts[x1] heterozygosity. (Willecke et al., 2006) mei-41^unspecified; wts^x1/+ flies show a higher tumor incidence than controls, with a 2-fold increase at baseline and >10-fold increase after treatment with ionizing radiation. Homozygous Mnn1^e200 mutants (Df(2L)Mnn1^e200 mutants in which milt function is rescued by expression of the milt⁺²² transgene) that have a wts^x1/+ background show a two-fold greater number of tumorigenic foci than wts^x1/+ single mutants. After treatment with ionizing radiation, the number of tumorigenic foci is two to three times higher in these mutants than in controls and is 7-fold higher after treatment with nitrogen mustard. (Busygina et al., 2004) scrib¹ wts^x1 double mutant clones in the eye disc produce tumours which do not show metastatic behaviour. Expression of Akt1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI in scrib¹ wts^x1 double mutant clones in the eye disc increases tumour size but does not result in metastatic behaviour. (Pagliarini and Xu, 2003) The Scer\GAL4^C5-driven hpo^Scer\UAS.cUa cell death phenotype observed in the wing can be partially suppressed through wts^x1 heterozygosity. (Udan et al., 2003)
Xenogenetic Interactions
Statement Reference A significantly enhanced rate of loss of heterozygosity in wts[x1] heterozygotes is only seen when both Hsap\AS3MT[Scer\UAS.T:Ivir\HA1] is expressed under the control of Scer\GAL4[da.G32] and the flies are exposed to inorganic arsenicals. (Muñiz Ortiz et al., 2011) Expression of Hsap\LATS1 using heat shock in flies containing wts^x1 clones suppresses tumour formation, and the wts^x1 cells develop into normal adult structures. (Tao et al., 1999)
Complementation & Rescue Data
Fails to complement	wts¹⁴⁸⁹ (Ghabrial et al., 2011)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Strong wts allele. (Xu et al., 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	lats^X1 (Pagliarini and Xu, 2003, Turenchalk et al., 1999, Zhang et al., 2008, Marek and Bale, 2006, Ghabrial et al., 2011) LATS^X1 (Tapon et al., 2002) lats^x1 (Tao et al., 1999, Xu et al., 1995, Busygina et al., 2004, Igaki et al., 2006, Igaki et al., 2006, Marek et al., 2008, Muñiz Ortiz et al., 2011) lats^X-1 (Ohsawa et al., 2011) warts^latsX1 (Menut et al., 2007) wts^latsX1 (Wu et al., 2003, Polesello et al., 2006, Colombani et al., 2006, Bennett and Harvey, 2006, Fernández et al., 2011, Emoto et al., 2006, Parrish et al., 2007, Genevet et al., 2009, Zeng et al., 2010) wts^LATSX1 (Tapon et al., 2002) wts^latsx1 (Mikeladze-Dvali et al., 2005) wts^LatsX1 (Bennett and Harvey, 2006, Wen et al., 2011) wts^X1 (Huang et al., 2005, Udan et al., 2003, Lai et al., 2005, Sidorov et al., 2002, Colombani et al., 2006, Matakatsu and Blair, 2012, Dong et al., 2007, Zhang et al., 2011, Oh and Irvine, 2008, Ren et al., 2010, Cho et al., 2006) wts^x1 (Nolo et al., 2006, Hamaratoglu et al., 2006, Hamaratoglu et al., 2006, Willecke et al., 2006, Sun et al., 2008, Varelas et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010, Badouel et al., 2009, Gilbert et al., 2011, Reddy and Irvine, 2011, Chen and Verheyen, 2012) wtsx1 (Badouel et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 50 )

Generate a list of	All references relating to this allele ( 50 )

List References by type	Research paper ( 45 ) Supplementary material ( 4 ) Review ( 1 )
Recent research papers ( 10 )
	Chen and Verheyen, 2012, Curr. Biol. 22(17): 1582--1586 Homeodomain-interacting protein kinase regulates yorkie activity to promote tissue growth. [FBrf0219448] Matakatsu and Blair, 2012, Development 139(8): 1498--1508 Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous. [FBrf0217773] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Muñiz Ortiz et al., 2011, Toxicol. Sci. 121(2): 303--311 A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. [FBrf0213756] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Wen et al., 2011, Mol. Cell. Neurosci. 48(1): 1--8 Nmnat exerts neuroprotective effects in dendrites and axons. [FBrf0214616] Zhang et al., 2011, Cell Death Differ. 18(8): 1346--1355 Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. [FBrf0214266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

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