FlyBase Allele Report: Dmel\wts[x1]

Somatic clones of wts^x1 homozygous cells in the wing disc overgrow and are larger than their control twinspot clones in the third instar larval wing disc.

(Deng et al., 2016)

wts^x1/wts^x1 somatic clones of type I lineages in the ventral nerve cord of third instar larvae in a heterozygous background have significantly smaller neurons, but an overall increased clone volume compared to controls.

(Poon et al., 2016)

wts^x1 homozygous mutant embryos from mothers whose germline consisted entirely of wts^x1 mutant cells (generated by the Ovo[D] germline clone method), and which thus are both zygotically and maternally wts^x1 mutant, display a significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage. No such significant increase is observed in only zygotically mutant embryos although they do display defective asymmetric division of heart and muscle progenitors P2 and P15 resulting in high proportion of hemisegments with either duplications or losses of muscle and pericardial cells.

Embryos both zygotically and maternally mutant for wts^x1 display defects in the asymmetric neuroblast (NB) division: disturbed asymmetric localization of polarity and cell-fate determinants, high frequency of mitotic spindle orientation defects as well as frequent failure to produce two NB daughter cells of the characteristic unequal size.

The type II brain neuroblast somatic clones homozygous mutant for wts^x1 display defects in asymmetric cell division: mislocalization of asymmetrically distributed proteins as well as mitotic spindle orientation defects.

(Keder et al., 2015)

wts^x1 mutant clones in the eye imaginal disc are overgrown compared to controls.

(Bosch et al., 2014)

wts^x1 mutant wings disc clones are overgrown.

(Koontz et al., 2013)

Approximately 60% of wts^x1 mutant border cell clusters are delayed at stage 10 of oogenesis. Unlike control clusters, F-actin fails to polarize to the outer rim of wts^x1 mutant clusters and instead tends to accumulate throughout the cluster. Border cell specification is not affected in these mutants.

(Lucas et al., 2013)

Cells in homozygous clones in the wing disc accumulate F-actin near the apical surface.

(Fernández et al., 2011)

Homozygous clones in the eye show progressive degeneration of photoreceptor cells.

(Napoletano et al., 2011)

wts^x1 mutants show a progressive loss of dendritic branches in class IV neurons without affecting axons.

(Wen et al., 2011)

Clones of tissue harbouring wts^x1 generated in the eye using the eyFlp/MARCM system overgrow dramatically and cause lethality at late third instar larval or early pupal stages of development.

Eye discs substantially over-grow when wts^x1 clones are generated using eyFlp/MARCM, with wts^x1 clones occupying almost the entire eye disc. Very few presumptive ommatidial clusters are observed and there is no obvious sign of the morphogenetic furrow.

(Zhang et al., 2011)

wts^x1 mutant cell clones display a large size and occupy large territories of wing and eye discs.

(Neto-Silva et al., 2010)

wts^x1 mutant MARCM clones contain 5-7 cells per clone, compared to 2-3 cells in wild-type clones. These clones contain differentiated absorptive enterocytes and secretory enteroendocrine cells indicating that intestine stem cell differentiation continues as in wild-type.

(Ren et al., 2010)

Induction of wts^x1 clones in third instar larval eye discs (generated using the eyFLP technique) results in massive overgrowth, with mutant cells covering almost the entire eye disc. The discs appear deformed with a folded excessive epithelium. No animals progress beyond the pupal stage.

(Badouel et al., 2009)

Homozygous clones in the wing disc have a growth advantage; the ratio of mutant clone area: area of the wild-type twin spot is 2.93.

(Genevet et al., 2009)

wts^x1 homozygous mutant clones generated in the male germline develop normally. 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells.

(Sun et al., 2008)

Adult eyes carrying homozygous mutant clones are overgrown.

(Zhang et al., 2008)

Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation. Neuronal differentiation is strongly impaired in these eye discs.

(Menut et al., 2007)

Heterozygous larvae show no significant defects in dendrite morphology of ddaC neurons.

Heterozygous males do not have ectopic sex combs on the second or third legs.

(Parrish et al., 2007)

Eye and wing imaginal discs heterozygous for wts^x1 are normal in size and morphology and are indistinguishable from wild-type discs.

(Bennett and Harvey, 2006)

Apoptosis is reduced by up to 3-fold in wts^x1 clones of wing or eye discs in response to γ-rays compared to wild-type tissue.

(Colombani et al., 2006)

Compared to wild-type ddaC (dorsal dendrite arborization neuron C) neurons, wts^x1 MARCM clones exhibit a severe and highly penetrant simplification of dendritic trees, with a significantly reduced number and length of dendritic branches, and hence a greatly reduced dendritic field.

In contrast to the severe dendritic defects caused by loss of wts function, wts^x1 MARCM clones of ddaC axons enter the ventral nerve cord at the appropriate position and show arborization patterns very similar to wild-type controls, with their axons terminating on the innermost fascicle and sending ipsilateral branches anteriorly and posteriorly and sometimes also a collateral branch towards the midline.

wts^x1 heterozygotes do not exhibit an obvious dendritic phenotype.

(Emoto et al., 2006)

The mid-pupal retina of wts^x1/wts^x1 animals contains a large excess of inter-ommatidial cells. The resulting adult eyes are distorted and lumpy.

(Hamaratoglu et al., 2006)

wts^x1 adults show tumor formation at extremely high penetrance. Each tumor represents a separate event as the tumors do not metastasize.

(Busygina et al., 2004)

Mutant clones in the eye disc result in noninvasive tumours that never move from the head region.

(Pagliarini and Xu, 2003)

When somatic clones of wts^x1 homozygous cells are generated throughout the eye disc using Scer\FLP1^ey.PN, none resulting animals survive to eclosion.

(Wu et al., 2003)

When wts^x1 clones are made in the developing eye more cell divisions are seen than in wild-type cells. Also the normal cell death that occurs in the retina is almost completely abolished.

(Tapon et al., 2002)

Lethal period is late embryonic and first larval instar. Mutant clones induced in first larval instar can be as large as 1/5 of the body size.

(Xu et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

wts^x1 has abnormal neuroanatomy phenotype, non-enhanceable by sav³

(Emoto et al., 2006)

Suppressed by

Statement

Reference

bam^Δ86, wts^x1 has increased cell number | germline clone | oogenesis phenotype, suppressible by Dcr-1^Q1147X/Dcr-1^Q1147X

(Zhang et al., 2024)

wts^x1 has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible by yki^KK109756/Scer\GAL4^Tub.PU/Scer\GAL80^ts.αTub84B

(Poon et al., 2016)

wts^x1 has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by yki^KK109756/Scer\GAL4^Tub.PU/Scer\GAL80^ts.αTub84B

(Poon et al., 2016)

wts^x1 has abnormal cell migration phenotype, suppressible by cpb^UAS.cWa/Scer\GAL4^slbo.2.6

(Lucas et al., 2013)

wts^x1 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.cZa

(Wen et al., 2011)

wts^x1 has abnormal neuroanatomy phenotype, suppressible by Nmnat^Δ4790-2

(Wen et al., 2011)

wts^x1 has lethal | somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has lethal | somatic clone phenotype, suppressible by Wbp2^GD7170/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has neoplasia | somatic clone phenotype, suppressible by Wbp2^GD7170/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by ex^UASp.EGFP/Scer\GAL4^Tub.PU

(Badouel et al., 2009)

wts^x1 has lethal | somatic clone | pupal stage phenotype, suppressible by ex^UASp.EGFP/Scer\GAL4^Tub.PU

(Badouel et al., 2009)

wts^x1 has lethal | somatic clone | pupal stage phenotype, suppressible by ex^CT.UASp.EGFP/Scer\GAL4^Tub.PU

(Badouel et al., 2009)

wts^x1 has visible | somatic clone phenotype, suppressible by sd^RNAi.C.UAS/Scer\GAL4^Tub.PU/sd^RNAi.N.UAS

(Zhang et al., 2008)

wts^x1 has neoplasia phenotype, suppressible by Hsap\LATS1^hs.PT

(Tao et al., 1999)

NOT suppressed by

Statement

Reference

wts^x1 has abnormal size | somatic clone phenotype, non-suppressible by Scer\GAL4^unspecified/Fbxl7^UAS.Tag:FLAG

(Bosch et al., 2014)

wts^x1 has abnormal size | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\GAL4^Tub.PU/ex^{linker.UASp.EGFP}

(Badouel et al., 2009)

wts^x1 has lethal | somatic clone | pupal stage phenotype, non-suppressible by Scer\GAL4^Tub.PU/ex^{linker.UASp.EGFP}

(Badouel et al., 2009)

Enhancer of

Statement

Reference

wts^x1/wts^x1 is an enhancer of increased cell number | oogenesis | germline clone phenotype of bam^Δ86

(Zhang et al., 2024)

wts^x1/wts[+] is an enhancer of abnormal size phenotype of Fbxl7^JF01515, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1/wts[+] is an enhancer of visible | dominant phenotype of Pc³

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of visible | dominant phenotype of Pc¹

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of abnormal size | third instar larval stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

wts^x1/wts[+] is an enhancer of hyperplasia | recessive phenotype of ex^AP49

(Hamaratoglu et al., 2006)

wts^x1/wts[+] is an enhancer of partially lethal - majority die phenotype of hpo^+t4.0, hpo^42-20

(Wu et al., 2003)

NOT Enhancer of

Statement

Reference

wts^x1/wts[+] is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

wts^x1/wts[+] is a non-enhancer of abnormal neuroanatomy phenotype of hpo^MGH4

(Emoto et al., 2006)

wts^x1 is a non-enhancer of neoplasia | somatic clone phenotype of mats^e235

(Lai et al., 2005)

Suppressor of

Statement

Reference

wts^x1/wts[+] is a suppressor | partially of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

wts^x1/wts[+] is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^nub.PU, ft^ΔECD.UAS

(Kong et al., 2021)

wts^x1/wts[+] is a suppressor | partially of abnormal size | adult stage phenotype of Hsap\LATS1^UAS.s, Scer\GAL4^en.PU

(Matsui et al., 2019)

wts^x1/wts[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^RapGAP1-OK6, Strip^RNAi.UAS.9

(Sakuma et al., 2016)

wts^x1/wts[+] is a suppressor of abnormal size phenotype of Fbxl7^UAS.Tag:FLAG, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1/wts[+] is a suppressor of abnormal size phenotype of Fbxl7^d08178, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1 is a suppressor of decreased cell number | somatic clone | larval stage phenotype of Scer\GAL4^FRT.Act5C, ex^UAS.cBa

(Cho et al., 2006)

wts^x1 is a suppressor | partially of increased cell death phenotype of p53^GMR.Ex

(Colombani et al., 2006)

wts^x1/wts^x1 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Hamaratoglu et al., 2006)

wts^x1/wts[+] is a suppressor of increased cell death phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

wts^x1 is a suppressor of increased cell death | larval stage phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

NOT Suppressor of

Statement

Reference

wts^x1/wts^x1 is a non-suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, yki^KK109756

(Poon et al., 2016)

wts^x1/wts^x1 is a non-suppressor of abnormal size | somatic clone | third instar larval stage phenotype of Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, yki^KK109756

(Poon et al., 2016)

wts^x1/wts[+] is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

wts^x1 is a non-suppressor of neoplasia | somatic clone phenotype of mats^e235

(Lai et al., 2005)

Other

Statement

Reference

Rox8^NIG.5422R, Scer\GAL4^GMR.PU, wts^x1/wts[+] has visible | adult stage phenotype

(Guo et al., 2020)

Rox8^NIG.5422R, Scer\GAL4^GMR.PU, wts^x1/wts[+] has increased size | adult stage phenotype

(Guo et al., 2020)

Scer\GAL4^Tub.PU, sd^KK108877, wts^x1 has cell lethal | somatic clone | adult stage phenotype

(Xu et al., 2018)

Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, wts^x1, yki^KK109756 has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype

(Poon et al., 2016)

Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, wts^x1, yki^KK109756 has abnormal size | somatic clone | third instar larval stage phenotype

(Poon et al., 2016)

baz⁴/baz[+], wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

insc[+]/insc^P49, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

pins[+]/pins^Δ50, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Galphai[+]/Gαi^KG01907, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Khc-73[+]/Khc-73^MI02026, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

cno², wts^x1/wts[+] has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

scrib[+]/scrib¹, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

pros[+]/pros¹⁷, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

numb[+]/numb¹, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

aurA^87Ac-3/aurA[+], wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Rap1[+]/Rap1^P5709, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

aPKC^k06403/aPKC[+], wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Fancd2^RNAi.UAS, Scer\GAL4^ey.PU, wts^x1/wts[+] has chemical sensitive phenotype

(Marek et al., 2008, Marek and Bale, 2006)

Fancd2^RNAi.UAS, Scer\GAL4^ey.PU, wts^x1/wts[+] has neoplasia | conditional phenotype

(Marek et al., 2008, Marek and Bale, 2006)

Fancd2^RNAi.UAS, Scer\GAL4^ey.PU, wts^x1/wts[+] has visible | chemical conditional phenotype

(Marek et al., 2008, Marek and Bale, 2006)

Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has chemical sensitive phenotype

(Marek et al., 2008)

Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has neoplasia | conditional phenotype

(Marek et al., 2008)

Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has visible | chemical conditional phenotype

(Marek et al., 2008)

Pc³, wts^x1/wts[+] has abnormal neuroanatomy | dominant | somatic clone phenotype

(Parrish et al., 2007)

sav³, wts^x1/wts[+] has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

mei-41^unspecified, wts^x1 has neoplasia phenotype

(Busygina et al., 2004)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

wts^x1 has dorsal multidendritic neuron ddaC | somatic clone & dendritic tree phenotype, non-enhanceable by sav³

(Emoto et al., 2006)

Suppressed by

Statement

Reference

bam^Δ86, wts^x1 has female germline cell | increased number | germline clone phenotype, suppressible by Dcr-1^Q1147X/Dcr-1^Q1147X

(Zhang et al., 2024)

wts^x1 has larval ventral nerve cord | somatic clone | third instar larval stage phenotype, suppressible by yki^KK109756/Scer\GAL4^Tub.PU/Scer\GAL80^ts.αTub84B

(Poon et al., 2016)

wts^x1 has wing disc | somatic clone phenotype, suppressible by Tgi^UAS.B

(Koontz et al., 2013)

wts^x1 has border follicle cell phenotype, suppressible by cpb^UAS.cWa/Scer\GAL4^slbo.2.6

(Lucas et al., 2013)

wts^x1 has larval multidendritic class IV neuron phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.cZa

(Wen et al., 2011)

wts^x1 has dendrite phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.cZa

(Wen et al., 2011)

wts^x1 has larval multidendritic class IV neuron phenotype, suppressible by Nmnat^Δ4790-2

(Wen et al., 2011)

wts^x1 has dendrite phenotype, suppressible by Nmnat^Δ4790-2

(Wen et al., 2011)

wts^x1 has eye disc | somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has ommatidial precursor cluster | somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has eye disc morphogenetic furrow | somatic clone phenotype, suppressible by Wbp2^KK108304/Scer\GAL4^αTub84B.PL

(Zhang et al., 2011)

wts^x1 has eye disc | somatic clone phenotype, suppressible by ex^UASp.EGFP/Scer\GAL4^Tub.PU

(Badouel et al., 2009)

wts^x1 has eye | somatic clone phenotype, suppressible by sd^RNAi.C.UAS/Scer\GAL4^Tub.PU/sd^RNAi.N.UAS

(Zhang et al., 2008)

NOT suppressed by

Statement

Reference

wts^x1 has eye disc | somatic clone phenotype, non-suppressible by par-1^HMS00405/Scer\GAL4^unspecified

(Huang et al., 2013)

wts^x1 has eye disc | somatic clone phenotype, non-suppressible by Scer\GAL4^Tub.PU/ex^{linker.UASp.EGFP}

(Badouel et al., 2009)

wts^x1 has wing disc | somatic clone phenotype, non-suppressible by crb^11A22

(Genevet et al., 2009)

Enhancer of

Statement

Reference

wts^x1/wts^x1 is an enhancer of female germline cell | increased number | germline clone phenotype of bam^Δ86

(Zhang et al., 2024)

wts^x1/wts[+] is an enhancer of wing phenotype of Fbxl7^JF01515, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1/wts[+] is an enhancer of mesothoracic leg phenotype of Pc¹

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of metathoracic leg phenotype of Pc¹

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of sex comb | ectopic phenotype of Pc³

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of mesothoracic leg phenotype of Pc³

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of metathoracic leg phenotype of Pc³

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of sex comb | ectopic phenotype of Pc¹

(Parrish et al., 2007)

wts^x1/wts[+] is an enhancer of wing disc | third instar larval stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

wts^x1/wts[+] is an enhancer of eye disc | third instar larval stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

wts^x1/wts[+] is an enhancer of wing disc phenotype of ex^AP49

(Hamaratoglu et al., 2006)

NOT Enhancer of

Statement

Reference

wts^x1/wts[+] is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

wts^x1/wts[+] is a non-enhancer of eye photoreceptor cell phenotype of Gug^75QN.UAS, Scer\GAL4^ninaE.PT

(Napoletano et al., 2011)

wts^x1/wts[+] is a non-enhancer of multidendritic dendrite phenotype of hpo^MGH4

(Emoto et al., 2006)

Suppressor of

Statement

Reference

wts^x1/wts[+] is a suppressor | partially of developing neuron | ectopic | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

wts^x1/wts[+] is a suppressor | partially of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

wts^x1/wts[+] is a suppressor | partially of peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

wts^x1/wts[+] is a suppressor of wing phenotype of Scer\GAL4^nub.PU, ft^ΔECD.UAS

(Kong et al., 2021)

wts^x1 is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Abca3^GD3708, Scer\GAL4^elav.PLu

(Ueoka et al., 2020)

wts^x1/wts[+] is a suppressor | partially of wing blade posterior compartment | adult stage phenotype of Hsap\LATS1^UAS.s, Scer\GAL4^en.PU

(Matsui et al., 2019)

wts^x1/wts[+] is a suppressor of NMJ bouton | increased number phenotype of Scer\GAL4^RapGAP1-OK6, Strip^RNAi.UAS.9

(Sakuma et al., 2016)

wts^x1/wts[+] is a suppressor of wing phenotype of Fbxl7^UAS.Tag:FLAG, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1/wts[+] is a suppressor of wing phenotype of Fbxl7^d08178, Scer\GAL4^nub-AC-62

(Bosch et al., 2014)

wts^x1 is a suppressor of eye disc | somatic clone phenotype of Scer\GAL4^unspecified, par-1^HMS00405

(Huang et al., 2013)

wts^x1 is a suppressor of wing disc | somatic clone | larval stage phenotype of Scer\GAL4^FRT.Act5C, ex^UAS.cBa

(Cho et al., 2006)

wts^x1/wts^x1 is a suppressor of interommatidial cell | pupal stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Hamaratoglu et al., 2006)

wts^x1/wts^x1 is a suppressor | partially of eye disc | third instar larval stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Hamaratoglu et al., 2006)

wts^x1/wts^x1 is a suppressor of interommatidial cell | pupal stage phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Hamaratoglu et al., 2006)

wts^x1/wts[+] is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, ft^ΔECD.UAS

(Willecke et al., 2006)

wts^x1/wts[+] is a suppressor of wing phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

NOT Suppressor of

Statement

Reference

wts^x1/wts^x1 is a non-suppressor of larval ventral nerve cord | somatic clone | third instar larval stage phenotype of Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, yki^KK109756

(Poon et al., 2016)

wts^x1/wts[+] is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

wts^x1 is a non-suppressor of eye disc | somatic clone phenotype of Tgi^UAS.B

(Koontz et al., 2013)

wts^x1/wts[+] is a non-suppressor of eye photoreceptor cell phenotype of Gug^75QN.UAS, Scer\GAL4^ninaE.PT

(Napoletano et al., 2011)

Other

Statement

Reference

Rox8^NIG.5422R, Scer\GAL4^GMR.PU, wts^x1/wts[+] has eye phenotype

(Guo et al., 2020)

Scer\GAL4^Tub.PU, Scer\GAL80^ts.αTub84B, wts^x1, yki^KK109756 has larval ventral nerve cord | somatic clone | third instar larval stage phenotype

(Poon et al., 2016)

aPKC^k06403/aPKC[+], wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

baz⁴/baz[+], wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

insc[+]/insc^P49, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

pins[+]/pins^Δ50, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Galphai[+]/Gαi^KG01907, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Khc-73[+]/Khc-73^MI02026, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

scrib[+]/scrib¹, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

pros[+]/pros¹⁷, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

numb[+]/numb¹, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

aurA^87Ac-3/aurA[+], wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

cno², wts^x1/wts[+] has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Rap1[+]/Rap1^P5709, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Fancd2^RNAi.UAS, Scer\GAL4^ey.PU, wts^x1/wts[+] has eye | chemical conditional phenotype

(Marek et al., 2008, Marek and Bale, 2006)

Mnn1^e200, Scer\GAL4^ey.PU, wts^x1/wts[+] has eye | chemical conditional phenotype

(Marek et al., 2008)

Pc³, wts^x1/wts[+] has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

sav³, wts^x1/wts[+] has dorsal multidendritic neuron ddaC | somatic clone & dendritic tree phenotype

(Emoto et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Individuals that both express Rox8^NIG.5422R under the control of Scer\GAL4^GMR.PU and are wts^x1/+ display enlarged eyes.

(Guo et al., 2020)

Clones that are both wts^x1 homozygous and express sd^KK108877 under the control of Scer\GAL4^Tub.PU are lethal in the wing.

(Xu et al., 2018)

The size (normalized to the respective twinspots) of wts^x1;Chchd3^D1 double mutant somatic clones in the wing disc is intermediate between the overgrowing wts^x1 clones and under-growing Chchd3^D1 clones but larger than the control wild-type clones.

(Deng et al., 2016)

wts^x1/wts^x1 somatic clones in a heterozygous background expressing yki^KK109756 under the control of Scer\GAL4^Tub.PU display an overall decrease in type I lineage clone volume in the ventral nerve cord of third instar larvae compared to controls.

(Poon et al., 2016)

The increased number of satellite boutons on neuromuscular junctions in third instar larvae expressing Strip^{dsRNA.shRNA.Scer\UAS.9} under the control of Scer\GAL4^RapGAP1-OK6 is suppressed by combination with a single copy of wts^x1.

(Sakuma et al., 2016)

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in embryos that are double heterozygous for wts^x1 and any of the following: cno², Rap1^P5709, aPKC^k06403, baz⁴, insc^P49, pins^Δ50, Gαi^KG01907, Khc-73^MI02026, scrib¹, pros¹⁷, numb¹ or aurA^87Ac-3. No such significant increase is observed in embryos double heterozygous for wts^x1 and either mud⁴ or l(2)gl⁴.

(Keder et al., 2015)

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of wts^x1.

(Zaessinger et al., 2015)

Expression of hppy^Scer\UAS.cZa under the control of Scer\GAL4^tub.PU does not suppress growth in wts^x1 mutant wing disc clones.

(Zheng et al., 2015)

The increased size of wts^x1 clones is not rescued by Fbxl7^{Scer\UAS.T:Zzzz\FLAG} expression.

(Bosch et al., 2014)

wts^x1 rescues the reduction in eye disc clone size seen when par-1^HMS00405 is expressed under the control of Scer\GAL4^unspecified, with the resulting clones similar in size to those seen with wts^x1 alone.

(Huang et al., 2013)

Expression of Tgi^Scer\UAS.B suppresses the overgrowth seen in wts^x1 mutant wing disc clones, resulting in a reduced clone size compared to wild type, similar to the phenotype seen in clones expressing Tgi^Scer\UAS.B alone.

(Koontz et al., 2013)

Overexpression of cpb^Scer\UAS.cWa is able to fully suppress the migration defect and F-actin polarisation defects of wts^x1 mutant border cell clusters.

(Lucas et al., 2013)

Whereas wts^x1 ddaC MARCM clones show a simplifed dendritic arbor with significantly reduced numbers of terminal branches, wts^x1 clones overexpressing Nmnat^Scer\UAS.cZa under the control of Scer\GAL4^elav-C155 elaborate dendrites with terminal branch numbers that do not differ statistically from wild-type controls. A similar rescue is seen in class IV neurons.

A transheterozygous combination of Nmnat^Δ4790-2 and wts^x1 does not show any synthetic phenotypes in affecting axon or dendrite development of class IV neurons.

(Wen et al., 2011)

When Wbp2^KK108304 or Wbp2^GD7170 is expressed in wts^x1-deficient tissues using eyFlp/MARCM, a significant increase in survival is observed with the majority of flies now reaching late pupal stages and forming pharate adults, with a small number emerging as fully developed adults.

When Wbp2^KK108304 or Wbp2^GD7170 is expressed in wts^x1-deficient tissues using eyFlp/MARCM, eye disc size is reduced, the amount of wts^x1 tissue relative to wild type tissue is decreased, and the differentiation of the developing eye is almost completely restored.

(Zhang et al., 2011)

Expression of ex^{Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^tub.PU largely suppresses the overgrowth phenotype seen in wts^x1 larval eye disc clones. The eye discs are no longer drastically deformed and retain a more normal shape. The pupal stage lethality is also partially rescued.

Expression of ex^{CT.Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^tub.PU partially suppresses the pupal stage lethality seen following the induction of wts^x1 larval eye disc clones.

Expression of ex^{linker.Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^tub.PU is unable to suppress the overgrowth phenotype seen in wts^x1 larval eye disc clones. The pupal stage lethality is also not rescued.

(Badouel et al., 2009)

The growth advantage of wts^x1 clones in the wing disc over their wild-type twin spots is not affected if the clones are also homozygous for crb².

(Genevet et al., 2009)

Expression of Fancd2^{dsRNA.Scer\UAS} in the eyes under the control of Scer\GAL4^ey.PU enhances the rate of eye tumor formation in wts^x1/+ mutant flies treated with nitrogen mustard.

A Mnn1^e200 mutant background enhances the rate of eye tumor formation in response to nitrogen mustard compared to wts^x1/+ mutant controls.

(Marek et al., 2008)

The eye overgrowth phenotype caused by wts^x1 clones is almost completely suppressed by co-expression of sd^{dsRNA.N.Scer\UAS} and sd^{dsRNA.C.Scer\UAS} under the control of Scer\GAL4^tub.

(Zhang et al., 2008)

Pc³/wts^x1 double heterozygous larvae show dendritic defects in ddaC neurons; there is a significant reduction in the number of dendritic branchpoints.

The ectopic sex comb phenotype seen on the second and third legs of Pc³/+ males is enhanced by wts^x1.

The ectopic sex comb phenotype seen on the second and third legs of Pc¹/+ males is enhanced by wts^x1/+.

(Parrish et al., 2007)

ft⁸/ft⁴²² mutants, heterozygous for wts^x1 exhibit a significant increase in size, both from wild-type and the ft⁸/ft⁴²² double mutant, and display an even more 'rippled' morphology.

(Bennett and Harvey, 2006)

A wts^x1 mutant background allows recovery of larval wing disc clones expressing ex^Scer\UAS.cBa under the control of Scer\GAL4^{Scer\FRT.Act5C}.

(Cho et al., 2006)

The p53^GMR.Ex-mediated induction of apoptosis in the posterior portion of late larval eye discs is reduced in wts^x1 clones.

(Colombani et al., 2006)

sav³/wts^x1 transheterozygotes exhibit simplified dendrites similar to moderately affected sav³ MARCM clones. These double mutants show a severe dendrite effect comparable to wts^x1 MARCM clones.

Transheterozygotes for wts^x1/hpo^MGH4 display simplified dendrites similar to wts^x1 mutants.

Transheterozygotes for wts^x1/trc¹ do not show any significant dendritic phenotypes.

(Emoto et al., 2006)

Wing disc overgrowth seen in ex^AP49 homozygous late third instar larvae is enhanced by wts^x1/+.

(Hamaratoglu et al., 2006)

The loss of inter-ommatidial cells in the developing retinas of ex^Scer\UAS.cBa; Scer\GAL4^GMR.PF animals at the mid-pupal stage is completely suppressed in wts^x1/wts^x1 somatic clones. The resulting clones have an excess of inter-ommatidial cells as do wts^x1/wts^x1 somatic clones do. Heterozygosity for wts^x1 partially suppresses the reduction in size and patterning defects seen in the eyes of ex^Scer\UAS.cBa; Scer\GAL4^GMR.PF animals.

The adult eye phenotype and the loss of interommmatidial cells seen in hpo^Scer\UAS.cUa; Scer\GAL4^GMR.PF mid-pupal retinas is suppressed by wts^x1/wts^x1.

(Hamaratoglu et al., 2006)

Overexpression of Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system in brain somatic clones mutant for scrib¹ and wts^x1 does not cause metastatic behaviour despite accelerated tumour growth.

(Igaki et al., 2006)

Expression of Fancd2^{dsRNA.Scer\UAS} in the eyes under the control of Scer\GAL4^ey.PU in a wts^x1/+ mutant background does not enhance the rate of eye tumor formation compared to controls in normal conditions. However the number of eye tumors is significantly increased when flies are treated with either nitrogen mustard or cisplatinum. This increase is restricted to eye tumors; the rate of tumours in other anatomical locations is similar to controls.

(Marek and Bale, 2006)

The ft^{ΔECD.Scer\UAS} phenotype (under the control of Scer\GAL4^nub-AC-62) is suppressed by wts^x1 heterozygosity.

(Willecke et al., 2006)

mei-41^unspecified; wts^x1/+ flies show a higher tumor incidence than controls, with a 2-fold increase at baseline and >10-fold increase after treatment with ionizing radiation.

Homozygous Mnn1^e200 mutants (Df(2L)Mnn1^e200 mutants in which milt function is rescued by expression of the milt⁺²² transgene) that have a wts^x1/+ background show a two-fold greater number of tumorigenic foci than wts^x1/+ single mutants. After treatment with ionizing radiation, the number of tumorigenic foci is two to three times higher in these mutants than in controls and is 7-fold higher after treatment with nitrogen mustard.

(Busygina et al., 2004)

scrib¹ wts^x1 double mutant clones in the eye disc produce tumours which do not show metastatic behaviour. Expression of Akt1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI in scrib¹ wts^x1 double mutant clones in the eye disc increases tumour size but does not result in metastatic behaviour.

(Pagliarini and Xu, 2003)

The Scer\GAL4^C5-driven hpo^Scer\UAS.cUa cell death phenotype observed in the wing can be partially suppressed through wts^x1 heterozygosity.

(Udan et al., 2003)

Xenogenetic Interactions

Statement

Reference

A significantly enhanced rate of loss of heterozygosity in wts^x1 heterozygotes is only seen when both Hsap\AS3MT^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^da.G32 and the flies are exposed to inorganic arsenicals.

(Muñiz Ortiz et al., 2011)

Expression of Hsap\LATS1 using heat shock in flies containing wts^x1 clones suppresses tumour formation, and the wts^x1 cells develop into normal adult structures.

(Tao et al., 1999)

Complementation and Rescue Data

Fails to complement

wts¹⁴⁸⁹

(Ghabrial et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

44251

w^*; wts^x1 P{neoFRT}82B/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

Strong wts allele.

(Xu et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

LATS^X1

(Boone et al., 2016, Tapon et al., 2002)

lats^X-1

(Ohsawa et al., 2011)

lats^X1

(Ghabrial et al., 2011, Williams et al., 2011, Zhang et al., 2008, Marek and Bale, 2006, Pagliarini and Xu, 2003, Turenchalk et al., 1999)

lats^x1

(Muñiz Ortiz et al., 2011, Marek et al., 2008, Igaki et al., 2006, Igaki et al., 2006, Busygina et al., 2004, Tao et al., 1999, Xu et al., 1995)

warts^latsX1

(Menut et al., 2007)

wts^LATSX1

(Tapon et al., 2002)

wts^LatsX1

(Wen et al., 2011, Bennett and Harvey, 2006)

wts^X1

(Gao et al., 2024, Zhang et al., 2024, Zhao et al., 2023, Cao et al., 2022, Kong et al., 2022, Liu et al., 2022, Neal et al., 2022, Velasquez et al., 2022, Kong et al., 2021, Guo et al., 2020, Ueoka et al., 2020, Arbouzova et al., 2019, Borreguero-Muñoz et al., 2019, Yee et al., 2019, Cho et al., 2018, Courgeon et al., 2018, Xu et al., 2018, Yu and Pan, 2018, Anderson et al., 2017, Moeller et al., 2017, Liu et al., 2016, Poon et al., 2016, Hirabayashi and Cagan, 2015, Parker and Struhl, 2015, Vrabioiu and Struhl, 2015, Wang and Baker, 2015, Zaessinger et al., 2015, Zheng et al., 2015, Bosch et al., 2014, Ikmi et al., 2014, Koontz et al., 2013, Lucas et al., 2013, Sidor et al., 2013, Hafezi et al., 2012, Matakatsu and Blair, 2012, Kawamori et al., 2011, Napoletano et al., 2011, Zhang et al., 2011, Ho et al., 2010, Ren et al., 2010, Oh et al., 2009, Oh and Irvine, 2008, Dong et al., 2007, Cho et al., 2006, Colombani et al., 2006, Huang et al., 2005, Lai et al., 2005, Udan et al., 2003, Sidorov et al., 2002)

wts^XI

(Fletcher et al., 2018, Poon et al., 2016)

wts^latsX1

(Sakuma et al., 2016, Hu et al., 2014, Huang et al., 2013, Fernández et al., 2011, Zeng et al., 2010, Genevet et al., 2009, Parrish et al., 2007, Bennett and Harvey, 2006, Colombani et al., 2006, Emoto et al., 2006, Polesello et al., 2006, Wu et al., 2003)

wts^latsx1

(Mikeladze-Dvali et al., 2005)

wtsx1

(Badouel et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (110)

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