Allele Dmel\Nrt^M54

General Information
Symbol	Dmel\Nrt^M54	Species	D. melanogaster
Name		FlyBase ID	FBal0044724
Feature type	allele	Associated gene	Dmel\Nrt
Also Known As	dab^M54, nrt^M54

Map ( GBrowse )
Allele class
Mutagen	X ray, ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Hill et al., 1995) X ray (Hill et al., 1995, Liebl et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References deletion 3L:16,768,132..16,768,141 comment=Approximate endpoints of 11bp deletion reported as starting in codon I405. Deletions leads to frameshift and early translation termination. evidence=experimental (Liebl et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 11bp deletion beginning in the codon for I405. The frameshift results in the translation of 2 unique residues before a stop codon is reached. (Liebl et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Nrt^M54 is an enhancer of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549 (Ruan et al., 2002)
Other
Statement Reference Abl¹, Df(1)N-8, Nrt^M54 has visible \| dominant phenotype (Giniger, 1998, Giniger, 1998) Abl¹, N^55e11, Nrt^M54 has visible \| dominant phenotype (Giniger, 1998, Giniger, 1998, Giniger, 1998) Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has neuroanatomy defective phenotype (Liebl et al., 2003, Liebl et al., 2003) Abl⁴/Abl¹, Nrt^M54 has neuroanatomy defective phenotype (Liebl et al., 2003, Liebl et al., 2003)
Phenotype Manifest In
Enhancer of
Statement Reference Nrt[+]/Nrt^M54 is an enhancer of heart primordium phenotype of sli² (MacMullin and Jacobs, 2006) Nrt^M54 is an enhancer of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549 (Ruan et al., 2002)
Suppressor of
Statement Reference Nrt[+]/Nrt^M54 is a suppressor \| partially of intersegmental nerve \| heat sensitive phenotype of N^l1N-ts1 (Crowner et al., 2003) Nrt^M54/Abl¹ is a suppressor \| partially of intersegmental nerve \| heat sensitive phenotype of N^l1N-ts1 (Crowner et al., 2003)
Other
Statement Reference Abl¹, Df(1)N-8, Nrt^M54 has eye phenotype (Giniger, 1998, Giniger, 1998) Abl¹, N^55e11, Nrt^M54 has eye phenotype (Giniger, 1998, Giniger, 1998, Giniger, 1998) Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has ventral nerve cord commissure phenotype (Liebl et al., 2003, Liebl et al., 2003) Abl⁴/Abl¹, Nrt^M54 has ventral nerve cord commissure phenotype (Liebl et al., 2003, Liebl et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference rhea¹/+; sli²/+ embryos show defects in heart formation. (MacMullin and Jacobs, 2006) 31% of segments have commissure defects in the central nervous system of Abl¹ Nrt^M54/Abl⁴ embryos. 63% of segments have commissure defects in the central nervous system of Abl¹ Nrt^M54/Nrt^M2 Df(3L)st-j7 embryos. (Liebl et al., 2003) The defects in photoreceptor cell projection patterns seen in larvae overexpressing msn^EP549 under the control of Scer\GAL4^GMR.PF are enhanced by Nrt^M54. (Ruan et al., 2002) Heterozygotes of Df(1)N-8 or N^55e11 with Abl¹, Nrt^M54 or In(3L)std11 show defects in eye development leading to rough eyes with high penetrance. (Giniger, 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced on: Abl¹. The Nrt^M54 mutant allele was originally thought to be a mutation in the Dab gene (see FBrf0049327, FBrf0058531 and FBrf0084025), but sequencing of the chromosome indicates that it is a lesion in the Nrt gene. (Liebl et al., 2003)
Comments
	"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA). (Hill et al., 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	dab^M54 (MacMullin and Jacobs, 2006, Liebl et al., 2003, Ruan et al., 2002, Giniger, 1998, Giniger, 2003.7.28) dab^m54 (Hill et al., 1995) Dab^m54 nrt^M54 (Liebl et al., 2003, Crowner et al., 2003, Giniger, 2003.7.28) Nrt^m54 Nrt^M54
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	MacMullin and Jacobs, 2006, Dev. Biol. 293(1): 154--164 Slit coordinates cardiac morphogenesis in Drosophila. [FBrf0190142] Crowner et al., 2003, Curr. Biol. 13(11): 967--972 Notch Steers Drosophila ISNb Motor Axons by Regulating the Abl Signaling Pathway. [FBrf0159717] Liebl et al., 2003, Development 130(14): 3217--3226 Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. [FBrf0162067] Ruan et al., 2002, Neuron 36(5): 831--842 Bifocal is a downstream target of the Ste20-like serine/threonine kinase Misshapen in regulating photoreceptor growth cone targeting in Drosophila. [FBrf0156013] Giniger, 1998, Neuron 20(4): 667--681 A role for Abl in Notch signaling. [FBrf0102318] Hill et al., 1995, Genetics 141(2): 595--606 Genetic interactions between the Drosophila Abelson, Abl, tyrosine kinase and failed axon connections (Fax), a novel protein in axon bundles. [FBrf0084025]
Personal communication to FlyBase	Giniger, 2003.7.28, UAS-Dl, nrt<up>M54</up>, trio<up>123.4</up> and sim-GAL4. UAS-Dl, nrt^M54, trio^123.4 and sim-GAL4. [FBrf0159722]

Allele Dmel\NrtM54

Allele Dmel\Nrt^M54