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General Information
Symbol
Dmel\Fas2e86
Species
D. melanogaster
Name
FlyBase ID
FBal0044815
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fasIIe86
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the P-element from Ecol\lacZFas2-A31.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Fas2EB112/Fas2e86 transheterozygotes do not have mushroom body lobe defects in the adult.
Dorsal longitudinal muscle a (DLMa) is innervated by a single motor neuron that has, on average, 5 contact points with the muscle in both wild type and Fas2e86 mutants.
Mutants exhibit a synaptic over-growth phenotype.
About 5% of mutant adult males show genitalia rotation defects.
The increase in frequency seen in the synaptic drive to aCC/RP2 during the first 28hr of larval life is not affected in the hypomorphic Fas2e86.
Mutants show overgrowth at the larval neuromuscular junction.
In 50% of the mushroom bodies of mutant animals, gross structural defects in the lobes and calyxes are seen.
50% increase in number of MN boutons at muscle 6. Mild heat induced expression of CrebB-17Aa.hs during larval stages significantly increases the quantal content of the synapse without altering quantal size (as shown by measuring excitatory postsynaptic potential, EPSP). Expression of CrebB-17Aa.hs increases the efficacy of single boutons in Fas2e86 to wild type.
In homozygous embryos the SNb fails to diverge from the ISN partially (partial bypass) in 6% segments. Fas2e93; beat-Ia2 flies have a strong beat-Ia phenotype, 86% segments have a divergence defect.
An increase in synaptic sprouting.
Growth of the synapse increases when Fas2 expression level is low causing a rise in number of boutons.
Neuronal activity is normal; bursting pattern of motor neuron action potentials controlling larval locomotion is similar to wild type. Excitatory postsynaptic potentials (EPSP) reveal synaptic transmission is also normal. Number of boutons is increased compared to wild type due to reduction in Fas2 expression, but the mean quantal content or the quantal size is not altered reflecting no change in synaptic strength. The extra boutons are not silent but should have an average quantal content lower than wild type. Bouton number does not increase when Fas2Scer\UAS.cLa is expressed from Scer\GAL4E62-2 in Fas2e86 larvae.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Fas2e86 is a suppressor of neuroanatomy defective phenotype of mysts1
Phenotype Manifest In
Suppressed by
Statement
Reference
Fas2e86 has synapse | ectopic phenotype, suppressible by GαsB19
Fas2e86 has bouton phenotype, suppressible by mysts1
Suppressor of
Statement
Reference
Fas2e86 is a suppressor of bouton phenotype of mysts1
Fas2e86 is a suppressor of neuromuscular junction phenotype of mysts1
Additional Comments
Genetic Interactions
Statement
Reference
The addition of G-sα60AB19 suppresses the synaptic over-growth phenotype seen in Fas2e86 mutants.
Bouton numbers at the larval neuromuscular junction are not significantly different from wild type in Fas2e86 mysts1 double mutants.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)