|Feature type||allele||Associated gene||Dmel\Fas2|
|Also Known As||fasIIe86|
|Allele class||hypomorphic allele - genetic evidence|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Dorsal longitudinal muscle a (DLMa) is innervated by a single motor neuron that has, on average, 5 contact points with the muscle in both wild type and Fas2e86 mutants.
Mutants exhibit a synaptic over-growth phenotype.
About 5% of mutant adult males show genitalia rotation defects.
The increase in frequency seen in the synaptic drive to aCC/RP2 during the first 28hr of larval life is not affected in the hypomorphic Fas2e86.
Mutants show overgrowth at the larval neuromuscular junction.
In 50% of the mushroom bodies of mutant animals, gross structural defects in the lobes and calyxes are seen.
50% increase in number of MN boutons at muscle 6. Mild heat induced expression of CrebB-17Aa.hs during larval stages significantly increases the quantal content of the synapse without altering quantal size (as shown by measuring excitatory postsynaptic potential, EPSP). Expression of CrebB-17Aa.hs increases the efficacy of single boutons in Fas2e86 to wild type.
In homozygous embryos the SNb fails to diverge from the ISN partially (partial bypass) in 6% segments. Fas2e93; beat-Ia2 flies have a strong beat-Ia phenotype, 86% segments have a divergence defect.
An increase in synaptic sprouting.
Growth of the synapse increases when Fas2 expression level is low causing a rise in number of boutons.
Neuronal activity is normal; bursting pattern of motor neuron action potentials controlling larval locomotion is similar to wild type. Excitatory postsynaptic potentials (EPSP) reveal synaptic transmission is also normal. Number of boutons is increased compared to wild type due to reduction in Fas2 expression, but the mean quantal content or the quantal size is not altered reflecting no change in synaptic strength. The extra boutons are not silent but should have an average quantal content lower than wild type. Bouton number does not increase when Fas2Scer\UAS.cLa is expressed from Scer\GAL4E62-2 in Fas2e86 larvae.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 6 )|
|Secondary FlyBase IDs|
|References ( 14 )|