|Feature type||allele||Associated gene||Dmel\Hsf|
|Map ( GBrowse )|
|Allele class||amorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: Q78@.
|Phenotype Manifest In|
Heterozygous larvae reared in a regimen of alternating hypoxia and reoxygenation show a greatly reduced survival compared to heterozygous larvae reared in normoxia (in contrast to wild-type larvae, which show no significant difference in survival between the two rearing conditions).
Homozygotes arrest at the 1st or 2nd larval instar stage and die after 2-3 days without any further growth or development. Viability is rescued in homozygous or hemizygous Hsf2/Df(2R)PclP2 flies carrying Hsf+t8. Homozygous clones induced after the larval lethal stage give rise to viable populations of cells that form normal structures in the adult. Homozygous clones induced before the larval lethal stage give rise to normal structures in the abdomen, but are not recovered in the head and thorax. Females mosaic for homozygous clones in the germ line are sterile. These clones produce egg chambers which contain a single oocyte and the normal number of 15 nurse cells, but are arrested at a pre-vitellogenic stage. The DNA content of the nurse cells is somewhat lower than normal.
Hsf[+]/Hsf1 is an enhancer of short lived phenotype of Avic\GFPA37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2, Scer\GAL4ey.PB
Hsf[+]/Hsf1 is an enhancer of size defective phenotype of Avic\GFPA37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2, Scer\GAL4ey.PB
Hsf[+]/Hsf1 is an enhancer of visible phenotype of Avic\GFPA37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2, Scer\GAL4ey.PB
|Phenotype Manifest In|
Hsf[+]/Hsf1 is an enhancer of eye phenotype of Avic\GFPA37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2, Scer\GAL4ey.PB
One copy of Hsf enhances the eye morphology and lifespan defects seen when Zzzz\Poly-Ala[A37.Scer\UAS.T:Avic\GFP-EGFP,T:SV40\nls2] is expressed under the control of Scer\GAL4[ey.PB].
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 6 )|