Allele Dmel\Hsf¹

General Information
Symbol	Dmel\Hsf¹	Species	D. melanogaster
Name		FlyBase ID	FBal0044857
Feature type	allele	Associated gene	Dmel\Hsf

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Jedlicka et al., 1997)
Mutagen	ethyl methanesulfonate (Jedlicka et al., 1996, Jedlicka et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:14,020,596..14,020,596 evidence=experimental pr_change=Q78@ na_change=C14020596T (Jedlicka et al., 1997)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q78@. (Jedlicka et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| recessive (Jedlicka et al., 1997) female sterile germline-dependent \| germline clone (Chen et al., 2009) lethal \| larval stage \| recessive (Jedlicka et al., 1997) stress response defective \| dominant (Baird et al., 2006)
Phenotype Manifest In
	egg chamber (Jedlicka et al., 1997) nurse cell (Jedlicka et al., 1997)
Detailed Description
	Statement Reference Females from germline clones with Hsf[1] produce no or droplet eggs. (Chen et al., 2009) Heterozygous larvae reared in a regimen of alternating hypoxia and reoxygenation show a greatly reduced survival compared to heterozygous larvae reared in normoxia (in contrast to wild-type larvae, which show no significant difference in survival between the two rearing conditions). (Baird et al., 2006) No eye abnormalities are seen in Hsf[1]/+. (Berger et al., 2006) Homozygotes arrest at the 1st or 2nd larval instar stage and die after 2-3 days without any further growth or development. Viability is rescued in homozygous or hemizygous Hsf²/Df(2R)Pcl^P2 flies carrying Hsf^+t8. Homozygous clones induced after the larval lethal stage give rise to viable populations of cells that form normal structures in the adult. Homozygous clones induced before the larval lethal stage give rise to normal structures in the abdomen, but are not recovered in the head and thorax. Females mosaic for homozygous clones in the germ line are sterile. These clones produce egg chambers which contain a single oocyte and the normal number of 15 nurse cells, but are arrested at a pre-vitellogenic stage. The DNA content of the nurse cells is somewhat lower than normal. (Jedlicka et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Hsf[+]/Hsf¹ is an enhancer of short lived phenotype of Avic\GFP^{A37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2}, Scer\GAL4^ey.PB (Berger et al., 2006) Hsf[+]/Hsf¹ is an enhancer of size defective phenotype of Avic\GFP^{A37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2}, Scer\GAL4^ey.PB (Berger et al., 2006) Hsf[+]/Hsf¹ is an enhancer of visible phenotype of Avic\GFP^{A37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2}, Scer\GAL4^ey.PB (Berger et al., 2006)
Phenotype Manifest In
Enhancer of
Statement Reference Hsf[+]/Hsf¹ is an enhancer of eye phenotype of Avic\GFP^{A37.EGFP.Scer\UAS.T:Zzzz\Poly-Ala.T:SV40\nls2}, Scer\GAL4^ey.PB (Berger et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference One copy of Hsf[1] enhances the eye morphology and lifespan defects seen when Zzzz\Poly-Ala[A37.Scer\UAS.T:Avic\GFP-EGFP,T:SV40\nls2] is expressed under the control of Scer\GAL4[ey.PB]. (Berger et al., 2006)
Complementation & Rescue Data
Rescued by	Hsf¹ is rescued by Hsf^+t8 (Jedlicka et al., 1997)
Comments
Stocks ( 2 )
Bloomington	5491 net¹ cn¹ Hsf¹/CyO
Kyoto	108257 net¹ cn¹ Hsf¹/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hsf¹ (Auluck et al., 2005, Chen et al., 2009) Hsf¹ (Baird et al., 2006, Berger et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Chen et al., 2009, Nucleic Acids Res. 37(4): 1061--1072 The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression. [FBrf0215469] Baird et al., 2006, J. Biol. Chem. 281(50): 38675--38681 Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. [FBrf0200052] Berger et al., 2006, Hum. Mol. Genet. 15(3): 453--465 Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. [FBrf0190826] Auluck et al., 2005, J. Biol. Chem. 280(4): 2873--2878 Mechanisms of suppression of alpha-synuclein neurotoxicity by geldanamycin in Drosophila. [FBrf0187783] Jedlicka et al., 1997, EMBO J. 16(9): 2452--2462 Multiple functions of Drosophila heat shock transcription factor in vivo. [FBrf0093528]
Abstract	Jedlicka et al., 1996, A. Dros. Res. Conf. 37: 386 Mutation of the heat shock factor gene affects not only the heat shock response but also larval development and oogenesis. [FBrf0085290]

Allele Dmel\Hsf1

Allele Dmel\Hsf¹