Allele Dmel\Mad^{Ubi-p63E.T:Hsap\MYC}

General Information
Symbol	Dmel\Mad^{Ubi-p63E.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0044926
Feature type	allele	Associated gene	Dmel\Mad

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Sekelsky et al., 1995) in vitro construct - regulatory fusion (Sekelsky et al., 1995, Das et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Ubi-p63E promoter sequences, containing a translation start and sequences including a T:Hsap\MYC epitope, drives expression of a Mad cDNA. (Sekelsky et al., 1995)
Carried in construct	P{UmMad} (Sekelsky et al., 1995, Dobens et al., 2000, Wiersdorff et al., 1996, Newfeld et al., 1996, Das et al., 1998, Wisotzkey et al., 1998)
Tagged with	T:Hsap\MYC (Wisotzkey et al., 1998, Das et al., 1998, Dobens et al., 2000, Sekelsky et al., 1995, Newfeld et al., 1996, Wiersdorff et al., 1996)
Cytology
Phenotypic Data
Phenotypic Class
	wild-type (Sekelsky et al., 1995)
Phenotype Manifest In

Detailed Description
	Statement Reference Does not rescue the lethality of Med^unspecified. (Das et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference Mad^{Ubi-p63E.T:Hsap\MYC} is a suppressor \| partially of eye-antennal disc phenotype of dpp^d-blk (Wiersdorff et al., 1996)
Additional Comments
Genetic Interactions
Statement Reference Rescues the dominant maternal-effect enhancement of dpp mutations. (Sekelsky et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Mad^{Ubi-p63E.T:Hsap\MYC} rescues Mad^unspecified (Sekelsky et al., 1995)
Comments	Rescues the recessive lethality of Mad mutations. (Sekelsky et al., 1995)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Mad^Ubi-p63E.PS Mad^{Ubi-p63E.T:Hsap\MYC} Mad^{Ubi-p63E.T:Myc}
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Dobens et al., 2000, Development 127(4): 745--754 Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary. [FBrf0125441] Das et al., 1998, Development 125(8): 1519--1528 The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. [FBrf0102615] Wisotzkey et al., 1998, Development 125(8): 1433--1445 Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. [FBrf0102610] Newfeld et al., 1996, Development 122(7): 2099--2108 Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. [FBrf0088659] Wiersdorff et al., 1996, Development 122(7): 2153--2162 Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. [FBrf0089199] Sekelsky et al., 1995, Genetics 139(3): 1347--1358 Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. [FBrf0080380]

Allele Dmel\MadUbi-p63E.T:Hsap\MYC

Allele Dmel\Mad^{Ubi-p63E.T:Hsap\MYC}