Allele Dmel\Psc^Arp1

General Information
Symbol	Dmel\Psc^Arp1	Species	D. melanogaster
Name		FlyBase ID	FBal0045013
Feature type	allele	Associated gene	Dmel\Psc
Also Known As	Psc^arp

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic epidermis (Soto et al., 1995)
Detailed Description
	Statement Reference Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter. (Fauvarque et al., 1995) Embryos lacking maternal and zygotic function show cuticle effects: missing denticle bands, failure of head involution, segmental transformations and twisting. This phenotype is paternally rescuable. (Soto et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Psc[+]/Psc^Arp1 is an enhancer of eye color defective phenotype of w^T40/w¹¹¹⁸ (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-d.826 (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.418 (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^{mC.ph-p.418bis} (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.812 (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.813 (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^{mC.ph-p.813bis} (Bloyer et al., 2003) Psc^Arp1 is an enhancer of eye color defective phenotype of w^ph-p.lac+3/w¹¹¹⁸ (Bloyer et al., 2003)
Suppressor of
Statement Reference Psc[+]/Psc^Arp1 is a suppressor of visible \| dominant \| homeotic phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) Psc^Arp1 is a suppressor of eye color defective phenotype of w^Fab-7.5F24 (Cavalli, 1999)
Phenotype Manifest In
NOT Enhanced by
Statement Reference Psc^Arp1 has phenotype, non-enhanceable by Alh^unspecified (Perrin et al., 2003)
NOT suppressed by
Statement Reference Psc^Arp1 has phenotype, non-suppressible by Alh^unspecified (Perrin et al., 2003)
Suppressor of
Statement Reference Psc[+]/Psc^Arp1 is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) Psc^Arp1 is a suppressor of pigment cell phenotype of w^Fab-7.5F24 (Cavalli, 1999)
Additional Comments
Genetic Interactions
Statement Reference Mutant heterozygotes show a weak suppression of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to darker eyes. (Cavalli, 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Psc^Arp1 Psc^arp (Gildea et al., 2000) Psc^Arp (Cavalli, 1999)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Bloyer et al., 2003, Dev. Biol. 261(2): 426--442 Identification and characterization of polyhomeotic PREs and TREs. [FBrf0167457] Boivin et al., 2003, Genetics 164(1): 195--208 Telomeric associated sequences of Drosophila recruit Polycomb-group proteins in vivo and can induce pairing-sensitive repression. [FBrf0158993] Perrin et al., 2003, Mol. Cell. Biol. 23(1): 119--130 The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions. [FBrf0155962] Gildea et al., 2000, Genetics 156(2): 645--663 A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. [FBrf0129826] Randsholt et al., 2000, Mech. Dev. 95(1-2): 89--99 polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs. [FBrf0130036] Fauvarque et al., 1995, Mech. Dev. 52(2-3): 343--355 Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. [FBrf0083917] Soto et al., 1995, Genetics 140(1): 231--243 Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster. [FBrf0082626]
Review	Cavalli, 1999, Science 286(5441): 955--958 Epigenetic inheritance of active chromatin after removal of the main transactivator. [FBrf0112149]

Allele Dmel\PscArp1

Allele Dmel\Psc^Arp1