FB2025_01 , released February 20, 2025
Allele: Dmel\Sry-δSDL1.lacZ
Open Close
General Information
Symbol
Dmel\Sry-δSDL1.lacZ
Species
D. melanogaster
Name
FlyBase ID
FBal0045138
Feature type
allele
Associated gene
Dmel\Sry-δ
Associated Insertion(s)
Carried in Construct
P{SDL1}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Noselli et al., 1992, Payre et al., 1990, Payre et al., 1989)
Progenitor genotype
Carried in construct
P{SDL1}
Cytology
Description

Contains Sry-δ sequence from approximately 1.7kb upstream of the transcription start site through to codon 384 (between the sixth and seventh zinc finger) fused in frame with lacZ.

(Payre et al., 1989)
Allele components
Component
Use(s)
Regulatory region(s)
Sry-δ
Sry-delta_SDL1
Encoded product / tool
Sry-δ
Tagged with
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      northern blot
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage
      (Payre et al., 1989)
      oogenesis
      (Payre et al., 1989)
      western blot
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage
      (Payre et al., 1989)
      larval stage
      (Payre et al., 1989)
      adult stage
      (Payre et al., 1989)
      oogenesis
      (Payre et al., 1989)
      Additional Information
      Statement
      Reference

      The Sry-deltaFBtr0091350:pb-XREcollacZ fusiontranscript is detected at high levels in ovaries and early embryos, and atgradually decreasing levels from germ band extension to lateembryogenesis. The transcript persists at low levels through the rest ofdevelopment.

      (Payre et al., 1989)

      Using lacZ-specific antibodies to western blots of embryos, the Sry-deltaFBtr0091350:pb-XRlacZ fusion protein is detected throughout embryogenesis.The lacZ activity of the Sry-deltaFBtr0091350:pb-XRlacZ fusion protein is detected in the nuclei of many adult somatic and germ line tissues. The oocyte provides the only instance of cytoplasmic localization. Activity is also present in first to third instar larvae, with strong nuclear expression in salivary glands and imaginal discs.

      (Payre et al., 1989)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sry-δSDL1.T:Ecol\lacZ
      Sry-δSDL1.T:lacZ
      Sry-δSDL1.lacZ
      Name Synonyms
      Secondary FlyBase IDs
        References (6)