FlyBase Allele Report: Dmel\Stat92E[HJ]

General Information

Symbol

Dmel\Stat92E^HJ

Species

D. melanogaster

Name

HiJak

FlyBase ID

FBal0045140

Feature type

allele

Associated gene

Dmel\Stat92E

Associated Insertion(s)

Carried in Construct

Also Known As

stat^HJ, D-stat^HJ

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Arbouzova, 2006, Luo et al., 1997, Yan et al., 1996)

Mutagen

ethyl methanesulfonate

(Yan et al., 1996)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Nucleotide substitution in the first intron, resulting in a reduction in the number of correctly spliced transcripts. The incorrectly spliced mRNA encodes a truncated 41 amino acid polypeptide.

(Yan et al., 1996)

A change from T to C at position 61 of the intron between exons 1 and 2 results in inefficient splicing out of this intron.

(Yan et al., 1996)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates colorectal cancer

modeled by Uvrag^HMS01357

(Nagy et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

embryonic/larval segmentation phenotype | embryonic stage

(Luo et al., 1997)

immune response defective

(Ahlers et al., 2019)

pair rule phenotype

(Yan et al., 1996, Yan et al., 1996)

viable

(Luo et al., 1997)

visible | dominant

(Yan et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Stat92E^HJ heterozygosity does not significantly affect the mitotic index in the adult midgut epithelium, as compared to controls.

(Nagy et al., 2016)

Stat92E^HJ mutants frequently contain additional wing vein material.

(Arbouzova, 2006)

The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of homozygous larvae is statistically indistinguishable from that of control siblings. The ability of homozygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

(Sorrentino et al., 2004)

Embryos exhibit segmentation defects. Adults exhibit adult segmentation abnormalities and the formation of ectopic wing veins.

(Luo et al., 1997)

Exerts a dominant negative effect on transcriptional activation by wild type Stat92E in tissue culture assays. Homozygotes show reduced viability, and patterning defects in wing veins and segmentation. Majority of homozygotes show larval segmentation defects similar to those caused by hop alleles, most frequently effecting the fifth abdominal segment. 6% of mutants show a pair rule segmentation phenotype.

(Yan et al., 1996)

In homozygotes viability is reduced. Surviving adults show ectopic partial wing veins in the posterior compartment. Homozygotes often show segment defects. Embryos most often lose segment 5, but defects in other segments occur also. At its most extreme this becomes a pair rule phenotype with deletion of the odd numbered abdominal segments. Dorsal trunks of the larval trachea are occasionally interrupted.

(Yan et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Stat92E^HJ is an enhancer of visible phenotype of upd1¹

(Tsai and Sun, 2004)

Suppressor of

Statement

Reference

Stat92E^HJ/Stat92E[+] is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

NOT Suppressor of

Statement

Reference

Stat92E^HJ is a non-suppressor of increased occurrence of cell division phenotype of hop^Tum

(Luo et al., 1997)

Stat92E^HJ is a non-suppressor of increased occurrence of cell division phenotype of hop^T42

(Luo et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

Stat92E^HJ has wing vein | ectopic phenotype, suppressible by hop^Tum

(Luo et al., 1997, Yan et al., 1996)

Enhancer of

Statement

Reference

Stat92E^HJ/Stat92E[+] is an enhancer of phenotype of Zzzz\rep^{Scer\UAS.T:Avic\GFP}/Sindbis\rep^UAS.GFP

(Avadhanula et al., 2009)

Stat92E^HJ is an enhancer of eye phenotype of upd1¹

(Tsai and Sun, 2004)

Stat92E^HJ is an enhancer of ommatidium phenotype of upd1¹

(Tsai and Sun, 2004)

Suppressor of

Statement

Reference

Stat92E^HJ/Stat92E[+] is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

Stat92E^HJ is a suppressor of phenotype of hop^Tum

(Luo et al., 1997, Yan et al., 1996, Yan et al., 1996)

Stat92E^HJ is a suppressor of phenotype of hop^T42

(Luo et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Stat92E^HJ heterozygosity suppresses the increased mitotic index in the adult midgut epithelium induced by the adulthood-only expression of Uvrag^HMS01357 under the control of Scer\GAL4^esg-NP5130 (and Gal80[ts], for the temporal control of expression).

(Nagy et al., 2016)

Df(1)os¹; Stat92E^HJ flies have a small eye of approximately 200 ommatidia, reduced compared to Df(1)os¹ mutant flies.

(Tsai and Sun, 2004)

Stat92E^HJ wing phenotype can be partially suppressed by hop^Tum. Can suppress the premature differentiation and aggregation but not the overproliferation of hop^T42 or hop^Tum larval haemocytes.

(Luo et al., 1997)

Dominantly suppresses the hop^Tum phenotype. Suppression is incomplete: some hematopoetic abnormalities and melanotic mass formation are still observed.

(Yan et al., 1996)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for Stat92E^HJ in a Scer\GAL4^Act5C.PI Zzzz\rep^{Scer\UAS.T:Avic\GFP} background results in increased Sindbis viral replication.

(Avadhanula et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24510

y¹ w^*; ry^* e¹ Stat92E^HJ/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

D-stat^HJ

(Remillieux-Leschelle et al., 2002, Luo et al., 1997)

Hi-Jak

(Luo and Dearolf, 2001)

STAT^HJ

(Tsai and Sun, 2004, Arbouzova et al., 2003)

Stat92E^HJ

(Ahlers et al., 2019, Avadhanula et al., 2009)

stat92E^HJ

(Arbouzova, 2006, Arbouzova and Zeidler, 2006, Arbouzova et al., 2006, Sorrentino et al., 2004, Myrick and Dearolf, 2000)

stat92E^hi-jak

(Zeidler et al., 2000)

stat92e^HJ

(Nagy et al., 2016)

stat^HJ

(Luo and Dearolf, 2001, Yan et al., 1996, Yan et al., 1996)

Name Synonyms

HiJak

(Yan et al., 1996, Yan et al., 1996)

Secondary FlyBase IDs

References (19)

Report Sections

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