Stat92EHJ heterozygosity does not significantly affect the mitotic index in the adult midgut epithelium, as compared to controls.
Stat92EHJ mutants frequently contain additional wing vein material.
The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of homozygous larvae is statistically indistinguishable from that of control siblings. The ability of homozygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Embryos exhibit segmentation defects. Adults exhibit adult segmentation abnormalities and the formation of ectopic wing veins.
Exerts a dominant negative effect on transcriptional activation by wild type Stat92E in tissue culture assays. Homozygotes show reduced viability, and patterning defects in wing veins and segmentation. Majority of homozygotes show larval segmentation defects similar to those caused by hop alleles, most frequently effecting the fifth abdominal segment. 6% of mutants show a pair rule segmentation phenotype.
In homozygotes viability is reduced. Surviving adults show ectopic partial wing veins in the posterior compartment. Homozygotes often show segment defects. Embryos most often lose segment 5, but defects in other segments occur also. At its most extreme this becomes a pair rule phenotype with deletion of the odd numbered abdominal segments. Dorsal trunks of the larval trachea are occasionally interrupted.