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General Information
Symbol
Dmel\Stat92EHJ
Species
D. melanogaster
Name
HiJak
FlyBase ID
FBal0045140
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
statHJ, D-statHJ
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution in the first intron, resulting in a reduction in the number of correctly spliced transcripts. The incorrectly spliced mRNA encodes a truncated 41 amino acid polypeptide.

A change from T to C at position 61 of the intron between exons 1 and 2 results in inefficient splicing out of this intron.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Stat92EHJ heterozygosity does not significantly affect the mitotic index in the adult midgut epithelium, as compared to controls.

Stat92EHJ mutants frequently contain additional wing vein material.

The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of homozygous larvae is statistically indistinguishable from that of control siblings. The ability of homozygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

Embryos exhibit segmentation defects. Adults exhibit adult segmentation abnormalities and the formation of ectopic wing veins.

Exerts a dominant negative effect on transcriptional activation by wild type Stat92E in tissue culture assays. Homozygotes show reduced viability, and patterning defects in wing veins and segmentation. Majority of homozygotes show larval segmentation defects similar to those caused by hop alleles, most frequently effecting the fifth abdominal segment. 6% of mutants show a pair rule segmentation phenotype.

In homozygotes viability is reduced. Surviving adults show ectopic partial wing veins in the posterior compartment. Homozygotes often show segment defects. Embryos most often lose segment 5, but defects in other segments occur also. At its most extreme this becomes a pair rule phenotype with deletion of the odd numbered abdominal segments. Dorsal trunks of the larval trachea are occasionally interrupted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Stat92EHJ is an enhancer of visible phenotype of upd11

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Stat92EHJ is an enhancer of eye phenotype of upd11

Stat92EHJ is an enhancer of ommatidium phenotype of upd11

Suppressor of
Statement
Reference

Stat92EHJ is a suppressor of phenotype of hopT42

Additional Comments
Genetic Interactions
Statement
Reference

Stat92EHJ heterozygosity suppresses the increased mitotic index in the adult midgut epithelium induced by the adulthood-only expression of UvragHMS01357 under the control of Scer\GAL4esg-NP5130 (and Gal80[ts], for the temporal control of expression).

Df(1)os1; Stat92EHJ flies have a small eye of approximately 200 ommatidia, reduced compared to Df(1)os1 mutant flies.

Stat92EHJ wing phenotype can be partially suppressed by hopTum. Can suppress the premature differentiation and aggregation but not the overproliferation of hopT42 or hopTum larval haemocytes.

Dominantly suppresses the hopTum phenotype. Suppression is incomplete: some hematopoetic abnormalities and melanotic mass formation are still observed.

Xenogenetic Interactions
Statement
Reference

Heterozygosity for Stat92EHJ in a Scer\GAL4Act5C.PI Zzzz\repScer\UAS.T:Avic\GFP background results in increased Sindbis viral replication.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
References (19)