Allele Dmel\Ubx^1:Cbx-1

General Information
Symbol	Dmel\Ubx^1:Cbx-1	Species	D. melanogaster
Name		FlyBase ID	FBal0045232
Feature type	allele	Associated gene	Dmel\Ubx
Also Known As	Cbx¹Ubx¹, Ubx^Cbx-1Ubx¹

Allele class
Mutagen	recombination
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	recombination (Hendrickson and Sakonju, 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Ubx¹ (Hendrickson and Sakonju, 1995) Ubx^Cbx-1 (Hendrickson and Sakonju, 1995)
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	visible \| dominant (Sipos et al., 1998, Muller et al., 1999, Hendrickson and Sakonju, 1995, Hartl et al., 2008, Hartl et al., 2008)
Phenotype Manifest In
	alula (Muller et al., 1999) wing (Sipos et al., 1998, Muller et al., 1999, Hendrickson and Sakonju, 1995, Hartl et al., 2008, Hartl et al., 2008)
Detailed Description
	Statement Reference 89.6% of heterozygotes show substantial loss of posterior wing tissue that often leads to the posterior region folding over the wing. 10.4% of heterozygotes have a large blister on the wing that comprises one third of the entire wing area or show wing necrosis. (Hartl et al., 2008) Heterozygotes have a wing with an abnormal shape and an alula that is greatly reduced in size. (Muller et al., 1999) z^a, Ubx^Cbx-1/+ flies do not differ from Ubx^Cbx-1/+, whereas the wings of z^a, Ubx^1:Cbx-1/+ are considerably less like halteres than those of Ubx^1:Cbx-1/+. (Goldsborough and Kornberg, 1996) The Cbx phenotype in Ubx^1:Cbx-1/In heterozygotes is enhanced by M(2)53¹. (Golic and Golic, 1996) Ubx^1:Cbx-1 heterozygotes show a dominant phenotype of warped and held-out wings because the Ubx^Cbx-1 part acts to misexpress Ubx⁺ on the homologue. This effect is disrupted by rearrangements that break once in between Ubx and the centromere and once elsewhere. (Hendrickson and Sakonju, 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Ubx^1:Cbx-1 has visible \| dominant phenotype, enhanceable by Cap-H2[+]/Cap-H2^TH1 (Hartl et al., 2008) Ubx^1:Cbx-1 has visible \| dominant phenotype, enhanceable by Cap-H2^Z3-0019/Cap-H2[+] (Hartl et al., 2008) Ubx^1:Cbx-1 has visible \| dominant phenotype, enhanceable by Df(3R)Exel6159/+ (Hartl et al., 2008)
Suppressed by
Statement Reference Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible \| partially by Scer\GAL4^sd-SG29.1/Cap-H2^EY09979 (Hartl et al., 2008) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible \| partially by Scer\GAL4^sd-SG29.1/Cap-H2^{Scer\UAS.P\T.T:Disc\RFP-mCherry} (Hartl et al., 2008, Hartl et al., 2008) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by Ab(?;3)TSR-2^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by In(2R)TSR-8^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by In(3LR)61F;81EF (Muller et al., 1999) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by In(3LR)80F;88C (Muller et al., 1999) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by In(3LR)TSR-10^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by In(3R)TSR-4^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)60F;84B (Muller et al., 1999) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)60F;85F (Muller et al., 1999) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-1^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-3^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-5^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-6^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-7^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(2;3)TSR-9^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has visible \| dominant phenotype, suppressible by T(Y;3)TSR-11^Sz (Sipos et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference Ubx^1:Cbx-1 has wing phenotype, enhanceable by Cap-H2[+]/Cap-H2^TH1 (Hartl et al., 2008) Ubx^1:Cbx-1 has wing phenotype, enhanceable by Cap-H2^Z3-0019/Cap-H2[+] (Hartl et al., 2008) Ubx^1:Cbx-1 has wing phenotype, enhanceable by Df(3R)Exel6159/+ (Hartl et al., 2008)
Suppressed by
Statement Reference Ubx^1:Cbx-1 has wing phenotype, suppressible \| partially by Scer\GAL4^sd-SG29.1/Cap-H2^EY09979 (Hartl et al., 2008) Ubx^1:Cbx-1 has wing phenotype, suppressible \| partially by Scer\GAL4^sd-SG29.1/Cap-H2^{Scer\UAS.P\T.T:Disc\RFP-mCherry} (Hartl et al., 2008, Hartl et al., 2008) Ubx^1:Cbx-1 has wing phenotype, suppressible by Ab(?;3)TSR-2^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by In(2R)TSR-8^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by In(3LR)TSR-10^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by In(3R)TSR-4^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-1^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-3^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-5^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-6^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-7^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-9^Sz (Sipos et al., 1998) Ubx^1:Cbx-1 has wing phenotype, suppressible by T(Y;3)TSR-11^Sz (Sipos et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference The severity of the Ubx[1:Cbx-1]/+ wing phenotype is dominantly enhanced by Cap-H2[Z3-0019], Cap-H2[TH1] and Df(3R)Exel6159; in each case the proportion of flies that show blistering or necrosis of the wing is increased. Expression of Cap-H2[Scer\UAS.P\T.T:Disc\RFP-mCherry] under the control of Scer\GAL4[sd-SG29.1] partially suppresses the Ubx[1:Cbx-1]/+ wing phenotype. Expression of Cap-H2[EY09979] under the control of Scer\GAL4[sd-SG29.1] partially suppresses the Ubx[1:Cbx-1]/+ wing phenotype. (Hartl et al., 2008) Expression of Cap-H2[Scer\UAS.P\T.T:Disc\RFP-mCherry] under the control of Scer\GAL4[sd-SG29.1] partially suppresses the wing phenotype of Ubx[1:Cbx-1]/+ flies. (Hartl et al., 2008) The Ubx^1:Cbx-1 phenotype is suppressed by T(2;3)60F;84B, T(2;3)60F;85F, In(3LR)61F;81EF and In(3LR)80F;88C. (Muller et al., 1999) The wing phenotype of Ubx^1:Cbx-1 heterozygotes is significantly suppressed by T(2;3)TSR-1^Sz, Ab(?;3)TSR-2^Sz, T(2;3)TSR-3^Sz, In(3R)TSR-4^Sz, T(2;3)TSR-5^Sz, T(2;3)TSR-6^Sz, T(2;3)TSR-7^Sz, In(2R)TSR-8^Sz, T(2;3)TSR-9^Sz, In(3LR)TSR-10^Sz or T(Y;3)TSR-11^Sz. (Sipos et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	The influence of various Ubx mutations in trans to Ubx^1:Cbx-1 on the synapsis-dependent phenotype of the Ubx^1:Cbx-1 chromosome has been studied. (Babu et al., 1987)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Cbx (Golic and Golic, 1996) Cbx¹Ubx¹ (Muller et al., 1999, Sipos et al., 1998, Hendrickson and Sakonju, 1995, Babu et al., 1987) Cbx Ubx (Duncan and Montgomery, 2002) Ubx (Golic and Golic, 1996) Ubx^1:Cbx-1 Ubx^Cbx-1Ubx¹ (Hartl et al., 2008, Hartl et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Ou et al., 2009, Genetics 183(2): 483--496 Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster. [FBrf0209218] Hartl et al., 2008, Science 322(5906): 1384--1387 Chromosome alignment and transvection are antagonized by condensin II. [FBrf0206308] Muller et al., 1999, Genetics 153(3): 1333--1356 The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions. [FBrf0111986] Sipos et al., 1998, Genetics 149(2): 1031--1050 Transvection in the Drosophila abd-B domain. Extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter. [FBrf0103039] Goldsborough and Kornberg, 1996, Nature 381(6585): 807--810 Reduction of transcription by homologue asynapsis in Drosophila imaginal discs. [FBrf0088157] Golic and Golic, 1996, Genetics 143(1): 385--400 A quantitative measure of the mitotic pairing alleles in Drosophila melanogaster and the influence of structural heterozygosity. [FBrf0087226] Hendrickson and Sakonju, 1995, Genetics 139(2): 835--848 Cis and Trans interactions between the iab regulatory regions and abdominal-A and abdominal-B in Drosophila melanogaster. [FBrf0080088] Babu et al., 1987, Mol. Gen. Genet. 210: 557--563 Studies on transvection at the Bithorax complex in Drosophila melanogaster. [FBrf0047011]
Supplementary material	Hartl et al., 2008, Science 322(5906): Supporting Online Material. [FBrf0206401]
Biography	Duncan and Montgomery, 2002, Genetics 161(1): 1--10 E. B. Lewis and the Bithorax complex: part II. From cis-trans test to the genetic control of development. [FBrf0149009]

Allele Dmel\Ubx1:Cbx-1

Allele Dmel\Ubx^1:Cbx-1