FlyBase Allele Report: Dmel\hid[A206]

General Information

Symbol

Dmel\hid^A206

Species

D. melanogaster

Name

FlyBase ID

FBal0045273

Feature type

allele

Associated gene

Dmel\hid

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Abbott and Lengyel, 1991)

Mutagen

ethyl methanesulfonate

(Abbott and Lengyel, 1991)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(Grether et al., 1995)

Amino acid replacement: S261L.

(Grether et al., 1995)

Amino acid replacement: Q274term.

(Grether et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:18,173,104..18,173,104 [-]

Nucleotide change:

C18173104T

Reported nucleotide change:

C1181T

Amino acid change:

S261L | hid-PA; S261L | hid-PB

Reported amino acid change:

S261L

Comment:

One of two amino acid changes observed in W^hid-A206.

(Grether et al., 1995)

point_mutation

3L:18,173,066..18,173,066 [-]

Nucleotide change:

C18173066T

Reported nucleotide change:

C715T

Amino acid change:

Q274term | hid-PA; Q274term | hid-PB

Reported amino acid change:

Q274term

Comment:

One of two amino acid changes observed in W^hid-A206

(Grether et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinitis pigmentosa

modeled by ninaE^P37H, ninaE¹⁷

(Griciuc et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage

(Bhogal et al., 2016)

decreased cell death

(Grether et al., 1995)

decreased cell death | adult stage (with Df(3L)H99)

(Ohta et al., 2022)

lethal - all die during embryonic stage | recessive

(Abbott and Lengyel, 1991)

some die during embryonic stage | recessive

(Abbott and Lengyel, 1991)

Phenotype Manifest In

cephalopharyngeal skeleton

(Abbott and Lengyel, 1991)

dorsal fold

(Grether et al., 1995)

embryonic head

(Grether et al., 1995)

gonadal sheath proper primordium | female (with Df(3L)H99)

(DeFalco et al., 2003)

larval multidendritic class IV neuron | pupal stage

(Bhogal et al., 2016)

male terminalia

(Abbott and Lengyel, 1991)

wing (with Df(3L)H99)

(Ohta et al., 2022)

Detailed Description

Statement

Reference

hid^A206/+ third instar larvae show no defects in the field coverage and branching of the dendritic arbor in class IV dendritic arborizing neurons compared to controls but dendrite pruning of these neurons normally occurring during pupariation is in hid^A206 heterozygote pupae.

(Bhogal et al., 2016)

W^hid-A206/Df(3L)H99 have on average 5 "neurons medially located, just above antennal lobe" (mALs), comparable to 5 in wild-type females. The number in males (~30) is also unaffected.

(Kimura et al., 2005)

Stage 16 mutant female W^hid-A206/Df(3L)H99 mutant embryos have male-specific somatic gonadal precursors in the posterior of the gonad, although the cluster of these cells is slightly smaller than in wild-type males.

(DeFalco et al., 2003)

Homozygotes display significantly reduced viability. Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

(Grether et al., 1995)

Surviving transheterozygotes with W^hid-A22 or W^hid-A206 have an abnormal wing phenotype. The mutant wing appears opaque by comparison to wild type and occasionally contains trapped fluid. Transheterozygous males also possess improperly positioned terminalia. Some hemizygotes die before hatching and most of those that hatch possess properly formed cephalopharyngeal skeleton.

(Abbott and Lengyel, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hid^A206/hid[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, pum^HMS01685

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/W[+] is a suppressor of abnormal neurophysiology phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

hid^A206/W[+] is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

hid^A206/hid[+] is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^unspecified, hpo^UAS.cUa

(Udan et al., 2003)

hid^A206/W[+] is a suppressor of increased cell death phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

hid^A206/hid[+] is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

hid^A206/hid[+] is a suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, pum^HMS01685

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, pum^HMS01685

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of Scer\GAL4^ppk.1.9, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4^ppk.1.9, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of mitochondrion | third instar larval stage phenotype of Scer\GAL4^ppk.1.9, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

hid^A206/hid[+] is a suppressor of dendrite | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

hid^A206/W[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

hid^A206/W[+] is a suppressor of wing phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

hid^A206/W[+] is a suppressor of adult head phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The dendritic field coverage defects and loss of terminal branches as well as the increased branch retraction rate observed in class IV dendritic arborizing neurons of third instar larvae expressing nos^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4⁴⁷⁷ is suppressed by combination with a single copy of hid^A206 as is the increased density of mitochondria in dendrites observed with the RNAi driven by Scer\GAL4^ppk.1.9.

The dendritic field coverage and branching defects observed in class IV dendritic arborizing neurons of third instar larvae expressing pum^HMS01685 under the control of Scer\GAL4⁴⁷⁷ is suppressed by combination wth a single copy of hid^A206.

The dendritic arborization defects observed in class IV dendritic arborizing neurons of nos¹⁸/nos⁵³ third instar larvae are suppresed by combination with hid^A206.

(Bhogal et al., 2016)

ninaE^P37H, ninaE¹⁷, W^hid-A206/+ flies exhibit strong recovery of visual response to light stimulation.

(Griciuc et al., 2014)

A W^hid-A206 heterozygous background suppresses the degree of rpr^{UTR.Scer\UAS.T:Ivir\HA1}-indued eye ablation.

(Sandu et al., 2010)

The small wing and eye phenotypes caused by hpo^Scer\UAS.cUa overexpression, (through Scer\GAL4^unspecified or Scer\GAL4^C5) can be partially suppressed by heterozygosity for W^hid-A206, indicating that hpo requires W for its action.

(Udan et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutant males can be ranked based on the severity of terminalia rotation: Df(3L)H99 > W^hid-H109 > W^hid-A22 > W^hid-A206 > W^hid-A329 > W^hid-H89. The ranking is roughly similar to the one for the degree to which the alleles disrupt embryonic head development.

(Abbott and Lengyel, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

^A206

(Zhang et al., 2008)

Hid^LOF

(Griciuc et al., 2014)

HidA206

(Griciuc et al., 2014)

W^hid-A206

hid^A206

(Ohta et al., 2022, Bhogal et al., 2016, Sandu et al., 2010, Kimura et al., 2005, DeFalco et al., 2003, Udan et al., 2003, Grether et al., 1995, Abbott and Lengyel, 1991)

hid^hid-A206

Name Synonyms

Secondary FlyBase IDs

References (11)

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