FB2025_02 , released April 17, 2025
Allele: Dmel\hidrvE1
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General Information
Symbol
Dmel\hidrvE1
Species
D. melanogaster
Name
FlyBase ID
FBal0045288
Feature type
allele
Associated gene
Dmel\hid
Associated Insertion(s)
Carried in Construct
Also Known As
hidWR+E1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Abbott and Lengyel, 1991)
Progenitor genotype
hid1
(Abbott and Lengyel, 1991)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes display significantly reduced viability. Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

      (Grether et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      W[+]/hidrvE1 is a suppressor of eye phenotype of Mmus\Gria1Lc.UAS, Scer\GAL4hs.2sev

      (Yang et al., 2013)

      hidrvE1/Df(3L)H99 is a suppressor of eye phenotype of Mmus\Gria1Lc.UAS, Scer\GAL4hs.2sev

      (Yang et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      A WrvE1/+ or WrvE1/Df(3L)H99 heterozygous background rescues the reduced adult eye size found upon expression of Mmus\Gria1Lc.Scer\UAS under the control of Scer\GAL4hs.2sev.

      (Yang et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      WR+E1
      (Abbott and Lengyel, 1991)
      WrvE1
      hidWR+E1
      (Yang et al., 2013, Grether et al., 1995)
      hidrvE1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)