FlyBase Allele Report: Dmel\dally[ΔP-188]

General Information

Symbol

Dmel\dally^ΔP-188

Species

D. melanogaster

Name

FlyBase ID

FBal0045488

Feature type

allele

Associated gene

Dmel\dally

Associated Insertion(s)

P{?'PZ}dally^ΔP-188

Carried in Construct

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tsuda et al., 1999)

loss of function allele

(Nakato et al., 1995)

Mutagen

Delta2-3 transposase

(Nakato et al., 1995)

Progenitor genotype

dally^P1

(Nakato et al., 1995)

Associated Insertion(s)

P{?'PZ}dally^ΔP-188

Cytology

Description

Imprecise excision that removes genomic sequences adjacent to the site of insertion.

(Nakato et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

segment polarity phenotype | germline clone

(Lin and Perrimon, 1999)

viable

(Lin and Perrimon, 1999)

visible

(Nakato et al., 1995)

Phenotype Manifest In

antenna

(Nakato et al., 1995)

anterior dorsocentral bristle (with dally^gem)

(Fujise et al., 2001)

embryo | germline clone

(Lin and Perrimon, 1999)

embryonic epidermis

(Tsuda et al., 1999)

embryonic epidermis (with dally^gem)

(Tsuda et al., 1999)

eye

(Nakato et al., 1995)

genitalia

(Nakato et al., 1995)

genitalia (with dally^gem)

(Tsuda et al., 1999)

lamina

(Nakato et al., 1995)

posterior dorsocentral bristle (with dally^gem)

(Fujise et al., 2001)

posterior supraalar bristle (with dally^gem)

(Fujise et al., 2001)

wing vein

(Nakato et al., 1995)

Detailed Description

Statement

Reference

In dally^gem/dally^ΔP-188 flies, 96% of animals lack the posterior supraalar bristle (pSA), 60% the anterior dorsocentral bristles (aDC) and 1% the posterior supraalar bristle (pSA).

(Fujise et al., 2001)

Homozygous embryos derived from dally^ΔP-188 germline clones show weak segment polarity defects (8% penetrance n=760).

(Lin and Perrimon, 1999)

16% of dally^gem/dally^ΔP-188 mutant embryos have cuticle defects. 6% of dally^ΔP-188/dally^ΔP-188 mutant embryos have cuticle defects. About 90% of dally^ΔP-188/dally^gem flies show abnormalities in their genitalia.

(Tsuda et al., 1999)

Abnormalities in the eye, antenna, genitalia and wing (similar to dally⁰⁶⁴⁶⁴). Disruptions in the cell cycle progression of lamina precursors.

(Nakato et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dally^ΔP-188, dpp^d5/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

dally^ΔP-188/dally^gem has embryonic epidermis phenotype, enhanceable by wg^l-12/wg[+]

(Tsuda et al., 1999)

Suppressed by

Statement

Reference

dally^ΔP-188/dally^gem has genitalia phenotype, suppressible by wg^l-12/wg[+]

(Tsuda et al., 1999)

Other

Statement

Reference

dally^ΔP-188, sgl⁰⁸³¹⁰ has embryonic epidermis phenotype

(Tsuda et al., 1999)

dally^ΔP-188, dpp^d5/dpp[+] has eye phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d5/dpp[+] has antenna phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has eye phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has antenna phenotype

(Jackson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for wg^l-12 increases the penetrance of cuticle defects in dally^ΔP-188/dally^gem embryos from 16% to 41%. Embryos heterozygous for dally^ΔP-188 derived from mothers heterozygous for sgl⁰⁸³¹⁰ show cuticle defects characteristic of a reduction in wg signalling. The abnormal genitalia phenotype of dally^ΔP-188/dally^gem flies is dominantly suppressed (down to less than 5% penetrance) by wg^l-12.

(Tsuda et al., 1999)

Flies heterozygous for both dally⁰⁶⁴⁶⁴ and either dpp^d5 or dpp^d12 show eye and antenna abnormalities. Heterozygotes with the more severe dpp^d12 allele show a higher frequency of abnormalities than heterozygotes with the milder dpp^d5 allele.

(Jackson et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dally^ΔP-188

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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