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General Information
Symbol
Dmel\dppUAS.cFa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Frasch
FlyBase ID
FBal0045515
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dpp
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a dpp cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of dppScer\UAS.cFa under the control of Scer\GAL4bi-md653 leads to the appearance of wing-like bristles and trichomes on the haltere.

Clones expressing dppScer\UAS.cFa under the control of Scer\GAL4Act5C.PP in the anterior portion of the eye disc initiate ectopic morphogenetic furrows (MFs) and premature photoreceptor cell differentiation. The ectopic MF forms a circle that grows outward in a concentric progression, creating a growing patch of photoreceptors within it. Glial cell migration towards the anterior patch of photoreceptors is sometimes seen. In these cases, the patch of photoreceptors is large and located in close proximity to the main body of photoreceptors. The number of glial cells reaching the anterior patches is small compared with areas of the same size in the posterior of the eye disc. In all cases where there is glial cell migration towards the anterior patches of photoreceptors, the anterior photoreceptors have axonal processes but they are very short and project randomly.

Flies expressing dppScer\UAS.cFa under the control of Scer\GAL4ey.PH show induction of photoreceptor differentiation from the anterior margin of the eye disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The deformed, wrinkled wing phenotype seen in dppScer\UAS.cFa; Scer\GAL4Ser.PGF flies is completely suppresessed by TolloScer\UAS.cKa.

Coexpression of dppScer\UAS.cFa and vgScer\UAS.cKa, both under the control of Scer\GAL4bi-md653, leads to an enhancement of the haltere-to-wing transformation seen when either transgene is expressed alone. Almost all haltere cells are transformed to wing-type cells as seen by the large number of bristles and trichomes. The phenotype is fully penetrant in pharate adults and flies expressing both transgenes are lethal at the pharate adult stage.

Expression of dppScer\UAS.cFa, under the control of Scer\GAL4en-e16E, rescues the squamous cell phenotype in hhts2 wing and leg discs.

Flies expressing wgScer\UAS.cAa under the control of Scer\GAL4ey.PH do not show photoreceptor development at the posterior of the eye disc. This phenotype is not rescued if the flies are also co-expressing dppScer\UAS.cFa. Flies expressing both dppScer\UAS.cFa and wgScer\UAS.cAa under the control of Scer\GAL4Act5C.PP also do not show photoreceptor development at the posterior margin of the eye disc. The ectopic photoreceptor differentiation seen in flies expressing dppScer\UAS.cFa under the control of Scer\GAL4ey.PH is not inhibited if the flies are also co-expressing wgScer\UAS.cAa. eyg1/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors. Photoreceptor development in these discs is not rescued by dppScer\UAS.cFa expressed under the control of Scer\GAL4dpp.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
dppScer\UAS.cFa
dppUAS.cFa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Frasch
Secondary FlyBase IDs
    References (18)