FlyBase Allele Report: Dmel\fng[UAS.cKa]

General Information

Symbol

Dmel\fng^UAS.cKa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Kim

FlyBase ID

FBal0045645

Feature type

allele

Associated gene

Dmel\fng

Associated Insertion(s)

Carried in Construct

P{UAS-fng.K}

Also Known As

uas-Fng, UAS-Fringe, UAS-fng27

Key Links

Transgenic product class

cDNA

(Kim et al., 1995)

wild_type

(Kim et al., 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Kim et al., 1995)

wild_type

(Kim et al., 1995)

Mutagen

in vitro construct

(Jacobsen et al., 1998, Klein and Martinez Arias, 1998, Milan et al., 1998, Papayannopoulos et al., 1998, Johnston et al., 1997, Kim et al., 1995)

Progenitor genotype

Carried in construct

P{UAS-fng.K}

Cytology

Description

UAS regulatory sequences drive expression of a 1.38kb EcoRI-BamHI fragment of fng cDNA.

(Kim et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

fng

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape, with Scer\GAL4^ptc-559.1

(Major and Irvine, 2005)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Xu et al., 2017)

decreased cell number, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

decreased size | adult stage, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

partially lethal, with Scer\GAL4^hs.PB

(Fleming et al., 1997)

visible, with Scer\GAL4^Act5C.PI

(Rauskolb and Irvine, 1999)

visible, with Scer\GAL4^Bx-MS1096

(Klein and Martinez Arias, 1998)

visible, with Scer\GAL4^c311

(Gibson and Schubiger, 2000)

visible, with Scer\GAL4^Dll-md23

(Bishop et al., 1999)

visible, with Scer\GAL4^dpp.blk1

(Grieder et al., 2007)

visible, with Scer\GAL4^ey.PH

(Lee et al., 2009, Dominguez and de Celis, 1998, Papayannopoulos et al., 1998)

visible, with Scer\GAL4^klu-G410

(Klein and Martinez Arias, 1998)

visible, with Scer\GAL4^ptc-559.1

(Klein and Martinez Arias, 1998)

visible | adult stage, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

visible | heat sensitive, with Scer\GAL4^69B

(Cho and Choi, 1998)

Phenotype Manifest In

adult optic lobe | larval stage, with Scer\GAL4^elav-C155

(Xu et al., 2017)

anterior dorsocentral bristle, with Scer\GAL4^klu-G410

(Klein and Martinez Arias, 1998)

anterior-posterior compartment boundary of the wing disc, with Scer\GAL4^ptc-559.1

(Major and Irvine, 2005)

eye, with Scer\GAL4^c311

(Gibson and Schubiger, 2000)

eye, with Scer\GAL4^ey.PH

(Lee et al., 2009, Dominguez et al., 2004, Dominguez and de Celis, 1998, Papayannopoulos et al., 1998)

eye, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

eye | heat sensitive, with Scer\GAL4^69B

(Cho and Choi, 1998)

eye disc, with Scer\GAL4^ey.PH

(Papayannopoulos et al., 1998)

female germline stem cell, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

femur, with Scer\GAL4^Act5C.PI

(Rauskolb and Irvine, 1999)

germarium cap cell, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

leg, with Scer\GAL4^Act5C.PI

(Rauskolb and Irvine, 1999)

leg & joint, with Scer\GAL4^Dll-md23

(Bishop et al., 1999)

leg joint, with Scer\GAL4^Act5C.PI

(Rauskolb and Irvine, 1999)

neuroblast | ectopic | larval stage, with Scer\GAL4^elav-C155

(Xu et al., 2017)

ommatidium, with Scer\GAL4^c311

(Gibson and Schubiger, 2000)

photoreceptor | heat sensitive, with Scer\GAL4^69B

(Cho and Choi, 1998)

polar follicle cell | increased number, with Scer\GAL4^unspecified

(Grammont and Irvine, 2001)

scutum, with Scer\GAL4^Bx-MS1096

(Klein and Martinez Arias, 1998)

tibia, with Scer\GAL4^Act5C.PI

(Rauskolb and Irvine, 1999)

wing, with Scer\GAL4^Bx-MS1096

(Klein and Martinez Arias, 1998)

wing, with Scer\GAL4^dpp.blk1

(Grieder et al., 2007)

wing, with Scer\GAL4^ptc-559.1

(Klein and Martinez Arias, 1998, Johnston et al., 1997)

wing disc | somatic clone | ventral, with Scer\GAL4^Act5C.PI

(Rauskolb et al., 1999)

wing margin, with Scer\GAL4^ptc-559.1

(Johnston et al., 1997)

wing margin | ectopic, with Scer\GAL4^ptc-559.1

(Klein and Martinez Arias, 1998, Johnston et al., 1997)

wing margin bristle | ectopic, with Scer\GAL4^ptc-559.1

(Ishikawa et al., 2005)

Detailed Description

Statement

Reference

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^elav-C155 leads to ectopic neuroblasts in the larval optic lobe medulla cortex.

(Xu et al., 2017)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^bab1-Gal4 (limited to the adult stages using Scer\GAL80^ts.αTub84B) produces a decrease in the number of germline stem cell and cap cells in one week old female flies compared to controls.

(Yang et al., 2013)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^twi.PG has little effect on eve-positive pericardial cell or DA1 muscle cell number.

(Babaoglan et al., 2009)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH results in a small eye phenotype.

(Lee et al., 2009)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^dpp.blk1 results in notched wings.

(Grieder et al., 2007)

Expression of fng^Scer\UAS.cKa, under the regulation of Scer\GAL4^ptc-559.1 results in the formation of ectopic margin bristles in the adult wing.

(Ishikawa et al., 2005)

In wing discs expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ptc-559.1, ventral cells along the anterior-posterior boundary show a rounded cellular morphology and an accumulation of F-actin at the adherens junction characteristic of cells at the dorsoventral boundary.

(Major and Irvine, 2005)

fng^Scer\UAS.cKa mutant third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) produce no defect in sensory organ precursor numbers.

(Pitsouli and Delidakis, 2005)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH results in a reproducible small eye phenotype.

(Dominguez et al., 2004)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^bi-omb-Gal4 does not significantly affect eye size.

(Singh et al., 2004)

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^byn-Gal4 does not have an effect on the formation of the hindgut boundary cells.

(Iwaki and Lengyel, 2002)

When expression is driven in clones by Scer\GAL4^unspecified extra polar cells develop at the termini of the egg chamber, though not in the main body follicle cells.

(Grammont and Irvine, 2001)

When expression is driven by Scer\GAL4^c311 eye size is dramatically reduced and ommatidia are square, though their array is regular.

(Gibson and Schubiger, 2000)

Expression of fng^Scer\UAS.cKa in the tibia and tarsal segments under the control of Scer\GAL4^Dll-md23 affects only the joints of the leg, resulting in their reduction or complete elimination. Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^klu-G410 results in no phenotype in the leg.

(Bishop et al., 1999)

Inhibition of normal joint formation and lengthwise fusion of the tibia and femur is seen in clones in the leg expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^Act5C.PI. The clones can also result in outgrowth of leg tissue. The outgrowth is composed of a mixture of wild-type cells and cells expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^Act5C.PI. Ectopic joint structures are also seen.

(Rauskolb and Irvine, 1999)

Flip-out somatic clones in the wing disc, in which there is clonal ectopic expression of fng^Scer\UAS.cKa, fail to respect the dorsal-ventral border.

(Rauskolb et al., 1999)

When expression is driven by Scer\GAL4^69B at 18^oC eyes are not affected. When expression is driven by Scer\GAL4^69B at 25^oC eyes of all progeny are reduced or missing. Photoreceptors fail to develop.

(Cho and Choi, 1998)

When expression is driven by Scer\GAL4^ey.PH, the eye is very much reduced.

(Dominguez and de Celis, 1998)

Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^{l(3)31-1-31-1} do not show any bristle defects.

(Jacobsen et al., 1998)

Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ptc-559.1 have a nick in the wings and a small ectopic wing margin. Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^klu-G410 lack the anterior dorsocentral bristles of the thorax. Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^Bx-MS1096 have nicked wings with normal veins and a reduction of bristles in the notum.

(Klein and Martinez Arias, 1998)

Overexpression of fng^Scer\UAS.cKa in a wild-type background under the control of Scer\GAL4^ap-md544 produces no phenotype.

(Milan et al., 1998)

Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH show dramatic loss of eye tissue. Tissue loss is visible in the developing eye imaginal disc, before the morphogenetic furrow moves across the eye. Eye tissue loss is not seen in flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF.

(Papayannopoulos et al., 1998)

Scer\GAL4^hs.PB-mediated expression causes a reduction in viability.

(Fleming et al., 1997)

Eliminates wing margin tissue at the tip of the wing and induces ectopic wing margin tissue in ventral cells when expressed using Scer\GAL4^ptc-559.1.

(Johnston et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has decreased size | adult stage phenotype, enhanceable by Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has visible | adult stage phenotype, enhanceable by Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has decreased size | adult stage phenotype, enhanceable by Sik3^S563A.PA.UAS/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has visible | adult stage phenotype, enhanceable by Sik3^S563A.PA.UAS/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^ey.PH, fng^UAS.cKa has visible phenotype, enhanceable by Hipk³/Hipk⁴

(Lee et al., 2009)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has visible | adult stage phenotype, non-enhanceable by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has decreased size | adult stage phenotype, non-enhanceable by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, fng^UAS.cKa has visible phenotype, suppressible | partially by Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has visible | adult stage phenotype, non-suppressible by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has decreased size | adult stage phenotype, non-suppressible by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^pros.PMG/fng^UAS.cKa is a suppressor of abnormal neuroanatomy phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^ey.PH, fng^UAS.cKa is a suppressor | partially of visible phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor of visible phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

Scer\GAL4^ap-md544, mew^UAS.cWa, fng^UAS.cKa is a suppressor | partially of visible phenotype of ap^md544/ap^ts78j

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor | partially of visible phenotype of ap^rK568/ap^md544

(O'Keefe and Thomas, 2001)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of visible phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of visible phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^ptc-559.1/fng^UAS.cKa is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

Scer\GAL4^Bx-MS1096/fng^UAS.cKa is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

Scer\GAL4^dpp.blk1/fng^UAS.cKa is a suppressor of visible | recessive phenotype of ap^UGO35

(Klein and Martinez Arias, 1998)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor of visible | dominant phenotype of Bx¹

(Milan et al., 1998)

fng^UAS.cKa/Scer\GAL4^hs.PB is a suppressor of lethal phenotype of Scer\GAL4^hs.PB, Ser^UAS.cGa

(Fleming et al., 1997)

fng^UAS.cKa/Scer\GAL4^hs.PB is a suppressor | partially of lethal phenotype of Scer\GAL4^hs.PB, Ser^{Bd.UAS.Tag:MYC}

(Hukriede et al., 1997)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, ap^UGO35, fng^UAS.cKa has visible phenotype

(Klein et al., 1998)

Scer\GAL4^hs.PB, Ser^UAS.cGa, fng^UAS.cKa has viable phenotype

(Fleming et al., 1997)

Scer\GAL4^ptc-559.1, Ser^{Bd.UAS.Tag:MYC}, fng^UAS.cKa has lethal | pharate adult stage phenotype

(Hukriede et al., 1997)

Scer\GAL4^ptc-559.1, Ser^{Bd.UAS.Tag:MYC}, fng^UAS.cKa has abnormal size | pharate adult stage phenotype

(Hukriede et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, enhanceable by Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, enhanceable by Sik3^S563A.PA.UAS/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, enhanceable by Hipk³/Hipk⁴

(Lee et al., 2009)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, enhanceable by ey^UAS.cHa/Scer\GAL4^ey.PH

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, enhanceable by Dl[+]/Delta^X

(Dominguez et al., 2004)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, non-enhanceable by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^twi.PG, fng^UAS.cKa, spdo^G104 has embryonic pericardial cell phenotype, non-enhanceable by numb²

(Babaoglan et al., 2009)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, non-enhanceable by Ser[+]/Ser^RX106

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, non-enhanceable by Ser[+]/Ser^RX82

(Dominguez et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible | partially by Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible by N^Ax-M1/N[+]

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible by ey^UAS.cHa/Scer\GAL4^ey.PH

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible by Scer\GAL4^ey.PH/eyg^UAS.lune

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible | partially by toe^UAS.cAa/Scer\GAL4^ey.PH

(Dominguez et al., 2004)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, suppressible | partially by N^int.SH.UAS, Scer\GAL4^ey.PH

(Dominguez and de Celis, 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, non-suppressible by Sik3^UAS.cSa/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Scer\GAL4^ey.PH, fng^UAS.cKa has eye phenotype, non-suppressible by toy^UAS.cCa/Scer\GAL4^ey.PH

(Dominguez et al., 2004)

Scer\GAL4^klu-G410, fng^UAS.cKa has anterior dorsocentral bristle phenotype, non-suppressible by Ser^CS94/Ser^RX106

(Klein and Martinez Arias, 1998)

Enhancer of

Statement

Reference

Scer\GAL4^{VP16.mat.αTub67C}/fng^UAS.cKa is an enhancer of sensory mother cell | third instar larval stage | ectopic | somatic clone phenotype of Delta^RevF10

(Pitsouli and Delidakis, 2005)

Scer\GAL4^{VP16.mat.αTub67C}/fng^UAS.cKa is an enhancer of sensory mother cell | third instar larval stage | ectopic phenotype of Delta^UAS.cLa

(Pitsouli and Delidakis, 2005)

Suppressor of

Statement

Reference

Scer\GAL4^pros.PMG/fng^UAS.cKa is a suppressor of dMP2 neuron | ectopic phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^pros.PMG/fng^UAS.cKa is a suppressor of vMP2 neuron phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^twi.PG/fng^UAS.cKa is a suppressor of embryonic pericardial cell phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^twi.PG, numb², fng^UAS.cKa is a suppressor of embryonic pericardial cell phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^twi.PG/fng^UAS.cKa is a suppressor of muscle cell of dorsal acute muscle 1 phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^ey.PH, fng^UAS.cKa is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor of wing margin phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

Scer\GAL4¹¹⁵¹/fng^UAS.cKa is a suppressor of indirect flight muscle cell phenotype of vg^null

(Bernard et al., 2006)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor | partially of wing phenotype of ap^rK568/ap^md544

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, mew^UAS.cWa, fng^UAS.cKa is a suppressor | partially of wing phenotype of ap^md544/ap^ts78j

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor of wing disc phenotype of ap^rK568/ap^md544

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor | partially of wing margin phenotype of ap^rK568/ap^md544

(O'Keefe and Thomas, 2001)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of presutural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of anterior notopleural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of posterior notopleural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of anterior supraalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of anterior postalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of posterior postalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of posterior dorsocentral bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of anterior scutellar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

fng^UAS.cKa, Scer\GAL4^{l(3)31-1-31-1} is a suppressor of posterior scutellar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of presutural bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of posterior notopleural bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of anterior supraalar bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of posterior supraalar bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of anterior postalar bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of anterior dorsocentral bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of posterior dorsocentral bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of anterior scutellar bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^{l(3)31-1-31-1}/fng^UAS.cKa is a suppressor of posterior scutellar bristle & trichogen cell phenotype of Scer\GAL4^{l(3)31-1-31-1}, Ser^UAS.cGa

(Jacobsen et al., 1998)

Scer\GAL4^ptc-559.1/fng^UAS.cKa is a suppressor of wing margin | ectopic phenotype of Scer\GAL4^ptc-559.1, Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

Scer\GAL4^Bx-MS1096/fng^UAS.cKa is a suppressor of wing vein phenotype of Scer\GAL4^Bx-MS1096, Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

Scer\GAL4^dpp.blk1/fng^UAS.cKa is a suppressor of wing phenotype of ap^UGO35

(Klein and Martinez Arias, 1998)

Scer\GAL4^ap-md544/fng^UAS.cKa is a suppressor of wing phenotype of Bx¹

(Milan et al., 1998)

Other

Statement

Reference

Scer\GAL4^ap-md544, ap^rK568/ap^md544, fng^UAS.cKa has haltere phenotype

(Tomoyasu et al., 2009)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has wing vein phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has dorsal row of wing sensilla phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has wing margin phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has alula & macrochaeta | supernumerary phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has sensillum campaniformium | supernumerary & wing vein L3 | ventral phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^md544/ap^ts78j, fng^UAS.cKa, mew^UAS.cWa has ventral row of wing sensilla | increased number phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^rK568/ap^md544, fng^UAS.cKa has dorsal row of wing sensilla phenotype

(O'Keefe and Thomas, 2001)

Scer\GAL4^ap-md544, ap^rK568/ap^md544, fng^UAS.cKa has ventral row of wing sensilla | increased number phenotype

(O'Keefe and Thomas, 2001)

Delta::N^ΔECN.UAS, Scer\GAL4^Act5C.PI, fng^UAS.cKa has wing disc | ventral | somatic clone phenotype

(Rauskolb et al., 1999)

N^int.SH.UAS, Scer\GAL4^ey.PH, fng^UAS.cKa has ommatidium phenotype

(Dominguez and de Celis, 1998)

Scer\GAL4^dpp.blk1, ap^UGO35, fng^UAS.cKa has wing | ectopic phenotype

(Klein et al., 1998)

Scer\GAL4^ptc-559.1, Ser^{Bd.UAS.Tag:MYC}, fng^UAS.cKa has leg | pharate adult stage phenotype

(Hukriede et al., 1997)

Scer\GAL4^ptc-559.1, Ser^{Bd.UAS.Tag:MYC}, fng^UAS.cKa has wing blade | pharate adult stage phenotype

(Hukriede et al., 1997)

Delta^UAS.cDa, Scer\GAL4^ptc-559.1, fng^UAS.cKa has wing | ventral phenotype

(Panin et al., 1997)

Delta^UAS.cDa, Scer\GAL4^ptc-559.1, fng^UAS.cKa has wing phenotype

(Panin et al., 1997)

Scer\GAL4^ptc-559.1, Ser^UAS.cSa, fng^UAS.cKa has wing phenotype

(Panin et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^twi.PG in a spdo^G104 background increases eve-positive pericardial cell number and decreases DA1 muscle numbers compared to embryos mutant for spdo^G104.

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^pros.PMG in a spdo^G104 mutant background restores vMP2 development in approximately 60% of hemisegments.

Expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^twi.PG in a numb² and spdo^G104 mutant background increases the number of eve-positive pericardial cells, and decreases the number of eve-positive DA1 muscle numbers compared to embryos mutant for spdo^G104. However, there is no change observed in this increased number of eve-positive pericardial cells between spdo^G104 embryos also expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^twi.PG alone, or in combination with numb².

fng^Scer\UAS.cKa over expression by Scer\GAL4^twi.PG in a spdo^G104 mutant background results in both daughter cells to adopting a svp-positive pericardial cell fate almost all of the time.

(Babaoglan et al., 2009)

Co-expression of either hipk^{Scer\UAS.T:Ivir\HA1} or gro^{EE.cLa.Scer\UAS} partially rescues the small eye phenotype caused by expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH.

The small eye phenotype caused by expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH is enhanced by hipk³/hipk⁴.

(Lee et al., 2009)

Flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 in a ap^rK568/ap^md544 background have ventralised halteres. In addition, the halteres form dark-pigmented bristles that are similar to those formed at the wing margin.

(Tomoyasu et al., 2009)

Adult thoraces of vg^null, Scer\GAL4¹¹⁵¹, fng^Scer\UAS.cKa flies show a significant rescue of muscle degeneration compared to thoraces of vg^null flies.

(Bernard et al., 2006)

Dl^Scer\UAS.cLa, fng^Scer\UAS.cKa double-mutant third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) display a significantly higher number of sensory organ precursors per cluster than single mutants. Dl^RevF10 fng^Scer\UAS.cKa third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) exhibit at least eight sensory organ precursors (SOPs) in approximately 47% of SOP positions scored. Approximately 12.5% of SOP positions display between four and eight ectopic SOPs, while approximately 28% exhibit between one and four SOPs, with only 12.5% exhibiting one SOP, as in wild-type.

(Pitsouli and Delidakis, 2005)

One copy of Dl^X enhances the small eye phenotype of flies in which fng^Scer\UAS.cKa is expressed under the control of Scer\GAL4^ey.PH. N^Ax-M1 suppresses this phenotype. However, in flies heterozygous for Ser^RX82 or Ser^RX106, the small eye phenotype is not enhanced. Scer\GAL4^ey.PH-mediated expression of eyg^{Scer\UAS.lune} fully rescues the eye size defect caused by Scer\GAL4^ey.PH-mediated expression of fng^Scer\UAS.cKa. This effect is also partially rescued by expression of toe^Scer\UAS.cAa under the control of Scer\GAL4^ey.PH. Scer\GAL4^ey.PH-mediated expression of toy^Scer\UAS.cCa has no effect on the small eye phenotype, while Scer\GAL4^ey.PH-mediated expression of ey^Scer\UAS.cHa can partially rescue the small eye phenotype in some flies but most often enhances this phenotype and induces the expression of tiny eyes in different places of the head.

(Dominguez et al., 2004)

The Bx¹ scalloped wing phenotype is suppressed by expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544.

(Milan et al., 2004)

Co-expression of tsh^Scer\UAS.cGa and fng^Scer\UAS.cKa under the control of Scer\GAL4^bi-omb-Gal4 results in suppression of eye development on the ventral margin in the eye disc and adult eye. Clones in the ventral part of the eye that are co-expressing tsh^Scer\UAS.cGa and fng^Scer\UAS.cKa under the control of Scer\GAL4^Act5C.PI show suppression of eye development in the eye disc, whereas clones in the dorsal part of the eye disc that are co-expressing tsh^Scer\UAS.cGa and fng^Scer\UAS.cKa under the control of Scer\GAL4^Act5C.PI induce ectopic eye development.

(Singh et al., 2004)

A sharp boundary between dorsal and ventral cells is restored in ap^rK568/ap^md544 wing discs expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544. No violations of the compartment boundary are seen. The resulting adult flies have wings of roughly normal size with clearly demarcated wing margin. The rescued wing margin is ventralised; dorsal-specific sensory bristles are completely missing along the anterior margin and cells on both sides of the margin secrete ventral bristle types. The dorsal and ventral wing surfaces are not adhered to each other, resulting in a balloon-like structure. ap^UGO35/ap^md544 flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 do not have wing margin defects. Coexpression of mew^Scer\UAS.cWa and fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 partially rescues the ap^ts78j/ap^md544 wing phenotype; the overall size and shape, apposition of the two surfaces, position of the wing margin and pattern of the wing veins are remarkably normal. However, these wings consist entirely of ventral cell types. Firstly, the rescued wing margins lack the dorsal-specific bristles types and instead have ventral bristle types on both surfaces. Secondly, the wings have many more alula bristles than normal (which in wild-type are derived only from the ventral surface). Thirdly, a mechanosensory campaniform sensillum that is normally located only on the ventral surface of vein L3 is duplicated and present on both surfaces of the rescued wing. Finally, the morphology of the wing veins indicate that they entirely of ventral identity (the veins show a ventral corrugation pattern on both surfaces of the wing).

(O'Keefe and Thomas, 2001)

Flip-out somatic clones in the wing disc, in which there is clonal ectopic expression of both Dl::N^{ΔECN.Scer\UAS} and fng^Scer\UAS.cKa, show a slight but consistent extension into the dorsal compartment.

(Rauskolb et al., 1999)

The eye-size effect can be partially rescued by simultaneous expression of N^{int.SH.Scer\UAS}, though ommatidia are abnormally arranged.

(Dominguez and de Celis, 1998)

The transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by Ser^Scer\UAS.cGa expressed under the control of Scer\GAL4^{l(3)31-1-31-1} is suppressed by co-expression of fng^Scer\UAS.cKa. The transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by Dl^Scer\UAS.cJa expressed under the control of Scer\GAL4^{l(3)31-1-31-1} is suppressed by co-expression of fng^Scer\UAS.cKa.

(Jacobsen et al., 1998)

The loss of wing seen in ap^UGO35 homozygotes is partially rescued by fng^Scer\UAS.cKa expressed under the control of Scer\GAL4^dpp.blk1. Flies expressing Ser^Scer\UAS.cSa under the control of Scer\GAL4^ptc-559.1 have smaller wings than normal which have two ectopic wing margins. The ectopic wing margin structures are reduced to a posterior stripe with characteristics of the posterior compartment if the flies are also co-expressing fng^Scer\UAS.cKa. The phenotype caused by expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^klu-G410 is not altered if the flies are also mutant for Ser^CS94/Ser^RX106. Suppresses the extra vein phenotype produced when Ser^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Bx-MS1096.

(Klein and Martinez Arias, 1998)

Scer\GAL4^dpp.blk1-mediated expression in ap^UGO35 mutants elicits an ectopic wing. Wing exhibits DV asymmetries and the margin is on the dorsal side.

(Klein et al., 1998)

The wing scalloping phenotype of Bx¹ heterozygotes is fully rescued by fng^Scer\UAS.cKa expressed under the control of Scer\GAL4^ap-md544, but the transformation phenotype of the alula is not.

(Milan et al., 1998)

Scer\GAL4^hs.PB-mediated expression of Ser^Scer\UAS.cGa causes death prior to the end of embryogenesis, simultaneous expression with fng^Scer\UAS.cKa reduces the lethality and restores normal neuronal differentiation, flies develop into phenotypically wild type adults.

(Fleming et al., 1997)

Coexpression of Ser^{Bd.Scer\UAS.T:Hsap\MYC} and fng^Scer\UAS.cKa via Scer\GAL4^hs.PB results in animals with apparently normal CNS development, and apparently improved viability when compared to Ser^{Bd.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^hs.PB alone. Can suppress the early pupal lethality of Ser^{Bd.Scer\UAS.T:Hsap\MYC} expressed via Scer\GAL4^ptc-559.1. Flies survive longer, to late pupal stages, after disc eversion and as pharate adults. The flies cannot eclose but exhibit complete though shortened legs and no wing blades.

(Hukriede et al., 1997)

Co-expression of fng^Scer\UAS.cKa with Ser^Scer\UAS.cSa in the wing (using Scer\GAL4^ptc-559.1) stimulates ectopic wing margin formation. Ectopic wing margin is formed in ventral cells of the wing when Dl^Scer\UAS.cDa and fng^Scer\UAS.cKa are co-expressed in the wing using Scer\GAL4^ptc-559.1.

(Panin et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^fng-11-26/fng^UAS.cKa rescues fng^11-26/fng^unspecified

(Cook, 2007.1.24)

Comments

Images (0)

Mutant

Wild-type