Allele Dmel\inv³⁰

General Information
Symbol	Dmel\inv³⁰	Species	D. melanogaster
Name		FlyBase ID	FBal0045908
Feature type	allele	Associated gene	Dmel\inv

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Tabata et al., 1995, Gustavson et al., 1996) loss of function allele (Bhat and Schedl, 1997)
Mutagen	Delta2-3 (Gustavson et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	inv^Xba21 (Gustavson et al., 1996)
Nature of the lesion	Statement Reference Small deficiency removing the first exon. (Bhat and Schedl, 1997) Intragenic deletion removing most of the inv transcription unit. The portion of the gene encoding the homeodomain is left intact. (Gustavson et al., 1996) Intragenic deletion removing approximately 27kb of the inv transcription unit, including the transcription start site, the first two exons and most of the second intron. (Tabata et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Tabata et al., 1995)
Phenotype Manifest In
	anterior crossvein (Gustavson et al., 1996) embryonic hindgut (Iwaki and Lengyel, 2002)
Detailed Description
	Statement Reference Gaps are seen in the posterior of the hindgut boundary cell rows in mutant embryos. (Iwaki and Lengyel, 2002) The development of the border cells of the hindgut (which normally form an anterior and posterior ring at the ends of the hindgut and bilateral strands that connect the two rings) is not affected in mutant embryos. (Takashima and Murakami, 2001) Homozygous embryos do not show duplications of the RP2 neuron. (Bhat and Schedl, 1997) Survives without abnormality over Df(2R)en-SFX31, except for slight defects on the anterior crossvein. (Gustavson et al., 1996) Adult flies are normal in appearance. (Tabata et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference en^9.6, inv³⁰ has lethal phenotype (Tabata et al., 1995) fra¹, inv³⁰ has lethal \| adult stage phenotype (Joly et al., 2007) fra¹, inv³⁰ has neuroanatomy defective phenotype (Joly et al., 2007)
Phenotype Manifest In
Other
Statement Reference en^9.6, inv³⁰ has embryonic epidermis phenotype (Tabata et al., 1995, Tabata et al., 1995) en^9.6, inv³⁰ has wing phenotype (Tabata et al., 1995, Tabata et al., 1995) fra¹, inv³⁰ has anterior commissure phenotype (Joly et al., 2007) fra¹, inv³⁰ has lateral tract phenotype (Joly et al., 2007) fra¹, inv³⁰ has posterior commissure phenotype (Joly et al., 2007) fra¹, inv³⁰ has ventral nerve cord phenotype (Joly et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Approximately 34% of fra[1]/inv[30] double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Approximately 87% of the segments are affected in these embryos. Approximately 15% of fra[1]/inv[30] double mutants are adult lethal. (Joly et al., 2007) In combination with en^9.6, defects are more extreme than for simple en mutant, en⁸. Clones in the wing of the double mutant inv³⁰, en^9.6 are associated with anterior transformations and mirror image duplications, similar in character to those caused by clones of Df(2R)en^E. (Tabata et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	7088 inv³⁰/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)inv³⁰ (Gustavson et al., 1996) inv³⁰ (Joly et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Joly et al., 2007, Dev. Biol. 301(2): 542--554 Engrailed controls the organization of the ventral nerve cord through frazzled regulation. [FBrf0194180] Iwaki and Lengyel, 2002, Mech. Dev. 114(1-2): 71--84 A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut. [FBrf0147142] Takashima and Murakami, 2001, Mech. Dev. 101(1-2): 79--90 Regulation of pattern formation in the Drosophila hindgut by wg, hh, dpp, and en. [FBrf0134749] Bhat and Schedl, 1997, Development 124(9): 1675--1688 Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. [FBrf0093362] Gustavson et al., 1996, Genetics 142(3): 893--906 The Drosophila engrailed and invected genes: Partners in regulation, expression and function. [FBrf0086432] Tabata et al., 1995, Development 121(10): 3359--3369 Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. [FBrf0084427]

Allele Dmel\inv30

Allele Dmel\inv³⁰