The precocious nuclear envelope breakdown (NEB) seen in stage 12 oocytes of mtrm126/+ females is strongly suppressed by polo16-1/+. The defects in karyosome morphology seen in mtrm126/+ oocytes observed within 20 minutes of NEB are also largely suppressed by polo16-1/+.
polo16-1/+ largely suppresses the karyosome maintenance defects seen in mtrm126/+ oocytes. polo16-1/+ fully suppresses the defect in X and 4th chromosome centromere co-orientation that is seen in mtrm126/+ females.
sub1/sub131; polo16-1/+ rare survivors are sickly and small with abdominal patterning defects. Late larval developmental arrest is observed. Severe defects in spindle organization are observed, and spindles are unusually short. Larvae show a higher percentage of cells in mitosis compared to sub1/sub131 or polo16-1/+, and nearly four times that of wild-type.