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General Information
Symbol
Dmel\polo16-1
Species
D. melanogaster
Name
FlyBase ID
FBal0046071
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)77Aa16-1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{SUPor-P}polo16-1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygosity for polo16-1 does not result in increased levels of achiasmate X or 4th chromosome non-disjunction in In(1)FM7/X females (the In(1)FM7 chromosome is present to fully suppress X chromosomal exchange).

polo1/polo16-1 females do not show gross defects in meiotic spindle formation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

polo16-1/polo[+] is an enhancer of abnormal mitotic cell cycle phenotype of sub131/sub1

Suppressor of
Statement
Reference

polo16-1/polo[+] is a suppressor of abnormal meiotic cell cycle | dominant phenotype of mtrm126

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

polo16-1/polo[+] is an enhancer of brain | larval stage phenotype of sub131/sub1

Suppressor of
Statement
Reference

polo16-1/polo[+] is a suppressor | partially of oocyte nucleus | oogenesis stage S12 phenotype of mtrm126

polo16-1/polo[+] is a suppressor of karyosome phenotype of mtrm126

Additional Comments
Genetic Interactions
Statement
Reference

poloKG03033/+ suppresses the elevated levels of achiasmate X and 4th chromosome nondisjunction seen in In(1)FM7/X mtrm126/+ females.

The precocious nuclear envelope breakdown (NEB) seen in stage 12 oocytes of mtrm126/+ females is strongly suppressed by polo16-1/+. The defects in karyosome morphology seen in mtrm126/+ oocytes observed within 20 minutes of NEB are also largely suppressed by polo16-1/+.

polo16-1/+ largely suppresses the karyosome maintenance defects seen in mtrm126/+ oocytes. polo16-1/+ fully suppresses the defect in X and 4th chromosome centromere co-orientation that is seen in mtrm126/+ females.

sub1/sub131; polo16-1/+ rare survivors are sickly and small with abdominal patterning defects. Late larval developmental arrest is observed. Severe defects in spindle organization are observed, and spindles are unusually short. Larvae show a higher percentage of cells in mitosis compared to sub1/sub131 or polo16-1/+, and nearly four times that of wild-type.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

polowt.T:Avic\GFP rescues the lethality of polo16-1/Df(3L)rdgC-co2 animals, but rescued females are sterile.

poloH518A.K520M.T:Avic\GFP fails to rescue the lethality of polo16-1/Df(3L)rdgC-co2 animals.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (10)