Allele Dmel\mod(mdg4)^T6

General Information
Symbol	Dmel\mod(mdg4)^T6	Species	D. melanogaster
Name		FlyBase ID	FBal0046118
Feature type	allele	Associated gene	Dmel\mod(mdg4)

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Gerasimova et al., 1995)
Mutagen	ethyl methanesulfonate (Gerasimova et al., 1995, Gerasimova and Corces, 1998, Mongelard et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutation is in the 67.2 exon. (Soltani-Bejnood et al., 2007) Amino acid replacement: ?578@. (Soltani-Bejnood et al., 2007) Nucleotide substitution: at position 137511 of AE003734. (Mongelard et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	female fertile (with Df(3R)GC14) (Soltani-Bejnood et al., 2007) lethal \| embryonic stage \| recessive (Gerasimova et al., 1995) viable (Mongelard et al., 2002, Soltani-Bejnood et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference ash1¹⁷, mod(mdg4)^T6 has visible \| homeotic phenotype, enhanceable by trx^B11 (Gerasimova and Corces, 1998) mod(mdg4)^T6, trx^B11 has visible \| dominant \| homeotic phenotype, enhanceable by ash1[+]/ash1¹⁷ (Gerasimova and Corces, 1998)
Enhancer of
Statement Reference Df(3R)GC14/mod(mdg4)^T6 is an enhancer of body color defective phenotype of y² (Soltani-Bejnood et al., 2007) mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible \| dominant \| homeotic phenotype of ash1[+]/ash1¹⁷, trx^B11 (Gerasimova and Corces, 1998) mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible \| dominant \| homeotic phenotype of brm[+]/brm², trx^E2 (Gerasimova and Corces, 1998) mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible \| dominant \| homeotic phenotype of brm², trx[+]/trx^E2 (Gerasimova and Corces, 1998)
Suppressor of
Statement Reference mod(mdg4)^T6 is a suppressor \| partially of body color defective \| recessive phenotype of y² (Mongelard et al., 2002) mod(mdg4)^T6 is a suppressor \| partially of body color defective phenotype of y² (Golovnin et al., 2008) mod(mdg4)^T6 is a suppressor \| partially of visible \| recessive phenotype of ct⁶ (Mongelard et al., 2002) mod(mdg4)^T6 is a suppressor \| partially of visible \| recessive phenotype of y² (Mongelard et al., 2002) mod(mdg4)^T6 is a suppressor of visible phenotype of ct⁶ (Golovnin et al., 2008) mod(mdg4)^T6 is a suppressor of visible phenotype of ct^K (Golovnin et al., 2008)
Other
Statement Reference mod(mdg4)^T6, trx^B11 has visible \| dominant \| homeotic phenotype (Gerasimova and Corces, 1998, Gerasimova and Corces, 1998)
Phenotype Manifest In
Enhanced by
Statement Reference mod(mdg4)^T6, trx^B11 has haltere phenotype, enhanceable by ash1[+]/ash1¹⁷ (Gerasimova and Corces, 1998)
Suppressor of
Statement Reference mod(mdg4)^T6 is a suppressor \| partially of adult epidermis phenotype of y² (Mongelard et al., 2002) mod(mdg4)^T6 is a suppressor \| partially of wing phenotype of ct⁶ (Mongelard et al., 2002) mod(mdg4)^T6 is a suppressor of adult abdomen phenotype of y² (Golovnin et al., 2008) mod(mdg4)^T6 is a suppressor of wing margin phenotype of ct⁶ (Golovnin et al., 2008) mod(mdg4)^T6 is a suppressor of wing margin phenotype of ct^K (Golovnin et al., 2008)
Other
Statement Reference mod(mdg4)^T6, trx^B11 has haltere phenotype (Gerasimova and Corces, 1998, Gerasimova and Corces, 1998) mod(mdg4)^T6, y² has abdominal tergite marginal bristle phenotype (Golovnin et al., 2008) mod(mdg4)^T16/mod(mdg4)^T6, y² has chaeta phenotype (Soltani-Bejnood et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference y[2] mod(mdg4)[T6] double mutant flies have a dappled abdomen with pale bristles. mod(mdg4)[T6] suppresses the "cut" wing phenotype observed in ct[6] mutant flies, and the wing margins are fully restored in these animals. The "cut" wing phenotype observed in ct[K] mutant animals is suppressed in a mod(mdg4)[T6] mutant background. (Golovnin et al., 2008) Body colour: y² ; mod(mdg4)^T6/mod(mdg4)^T16 flies have a y^- phenotype (yellow bristles, wings and bodies). (Soltani-Bejnood et al., 2007) mod(mdg4)^T6 trx^B11 double heterozygotes show a transformation of haltere to wing in 0.3% of cases. Increases the frequency of homeotic transformations seen in trx^B11 ash1¹⁷ double heterozygotes. Increases the frequency of homeotic transformations seen in trx^E2 brm² double heterozygotes. (Gerasimova and Corces, 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	mod(mdg4)⁰³⁸⁵² (Mongelard et al., 2002) mod(mdg4)^L3101 (Mongelard et al., 2002) mod(mdg4)^neo129 (Mongelard et al., 2002) mod(mdg4)^Z3-3298 (Soltani-Bejnood et al., 2007) mod(mdg4)^Z3-3401 (Soltani-Bejnood et al., 2007) mod(mdg4)^Z3-5578 (Soltani-Bejnood et al., 2007)
Fails to complement	mod(mdg4)^ul (Mongelard et al., 2002)
Comments	mod(mdg4)^T6 fully complements mod(mdg4)^Z3-3401, mod(mdg4)^Z3-5578 and mod(mdg4)^Z3-3298 with respect to X-Y chromosome nondisjunction in male meiosis. mod(mdg4)^T6/Df(3R)GC14 females do not show increased X chromosome nondisjunction compared to controls and the frequency of recombination in large intervals on the second and third chromosomes in the mutant females is normal. (Soltani-Bejnood et al., 2007) Member of Group II complementation group. Complementation statement based on transheterozygous phenotype in terms of suppression or non-suppression of y² and ct⁶ visible phenotypes. (Mongelard et al., 2002)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	mod(mdg4)^T6 (Pai et al., 2004, Melnikova et al., 2004, Golovnin et al., 2008, Golovnin et al., 2008) ModΔC (Golovnin et al., 2008) T6 (Soltani-Bejnood et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Golovnin et al., 2008, EMBO Rep. 9(5): 440--445 'Insulator bodies' are aggregates of proteins but not of insulators. [FBrf0205475] Soltani-Bejnood et al., 2007, Genetics 176(1): 161--180 Role of the mod(mdg4) common region in homolog segregation in Drosophila male meiosis. [FBrf0201774] Karakozova et al., 2004, Genetics 167(3): 1275--1280 The mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster. [FBrf0179270] Melnikova et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101(41): 14806--14811 Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila. [FBrf0180644] Pai et al., 2004, Mol. Cell 16(5): 737--748 The Centrosomal Protein CP190 Is a Component of the gypsy Chromatin Insulator. [FBrf0180528] Mongelard et al., 2002, Genetics 160(4): 1481--1487 Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila. [FBrf0147059] Ghosh et al., 2001, EMBO J. 20(10): 2518--2527 Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. [FBrf0136690] Wei and Brennan, 2001, Mol. Cell. Biol. 21(22): 7714--7720 The gypsy insulator can act as a promoter-specific transcriptional stimulator. [FBrf0139761] Gerasimova and Corces, 1998, Cell 92(4): 511--521 Polycomb and trithorax group proteins mediate the function of a chromatin insulator. [FBrf0100803] Gerasimova et al., 1995, Cell 82(4): 587--597 A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. [FBrf0083144]
Supplementary material	Golovnin et al., 2008, EMBO Rep. 9(5): Supporting Information. [FBrf0210976]

Allele Dmel\mod(mdg4)T6

Allele Dmel\mod(mdg4)^T6