Hemizygous larvae have overgrown lymph glands. The lymph gland lobes show increased mitotic activity compared to wild type. The concentration of circulating hemocytes in third instar larvae is significantly increased compared to controls and the fraction of circulating hemocytes that are undergoing cell division is also increased. The larvae show a significant increase in a blood cell type ("podocytes") with large pseudopod-like extensions compared to controls. These cells appear pear-shaped or spindle-shaped. Mutant larvae contain an increased fraction of lamellocytes (2.4%) compared to controls (0.2%). There is hardly any increase in cell death in the lymph glands of mutant larvae compared to controls. 70% of hemizygous lymph glands transplanted into wild-type females show an increase in size 5 days after transplantation, in contrast to wild-type lymph gland transplants, which do not show growth.
Transformation of second to first leg. Transformation of third to second leg.
10 to 35% of hemizygous males show loss of claws and have extra sex comb teeth on the meso- and metathoracic legs. A few individuals have small eyes.
Most homozygotes die as pharate adults. Lethal in combination with mxcSO
females have fewer egg chambers than wild-type flies, but are fully fertile and fecund. mxcM1
females do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. Homozygous and mxcG46
females have rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type. Hemizygous males have short, thin, non-coiling, empty testes, and paragonia are very reduced compared to wild-type.
Semi-lethal. Larvae have atrophic gonads. Show occasional floating tumors. Female heterozygotes with mxc1
are devoid of germ line. Adult escapers show variably penetrant homeotic transformations. The eye transformation resembles that of Dfd1