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General Information
Symbol
Dmel\insc8
Species
D. melanogaster
Name
FlyBase ID
FBal0046161
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos exhibit five ventral oblique muscles instead of three (as in wild type embryos). Embryonic muscle loss is due to defects in early somatic differentiation. Severe abnormalities are observed in a subset of pericardial cells.

Supernumerary muscles develop at the expense of the adult muscle precursors in homozygous embryos. The segment border muscle is duplicated at the expense of the lateral adult muscle precursors. Muscle LT3 is transformed to LT4.

Fusion defects of myoblasts.

Muscle pattern is reduced (ventral and pleural muscles) and disorganised (ventral lateral and dorsal muscles). The dorsal vessel is fairly normal. Most dorsal muscles are formed and inserted appropriately in the apodemes. Pattern formation of the cuticle is normal suggesting the observed muscle phenotype is not a consequence of epidermis defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)