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General Information
Symbol
Dmel\rlSu23
Species
D. melanogaster
Name
FlyBase ID
FBal0046361
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    G1113720A

    Reported nucleotide change:

    G1214A

    Amino acid change:

    D334N | rl-PC; D334N | rl-PD; D334N | rl-PE; D289N | rl-PG; D224N | rl-PH; D334N | rl-PI

    Reported amino acid change:

    D334N

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: G1214A. Amino acid replacement: D334N. Mutation is in kinase subdomain XI.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Heterozygotes have extra wing veins.

    Heterozygotes have a mild rough eye phenotype. There are multiple R7-like cells in each ommatidium. The flies have extra wing veins. Heterozygous females show a weak dominant sterility; 10.9% of the eggs laid by these females mated to normal males fail to hatch and 15.6% of these nonviable embryos have a reduction in the number of abdominal segments. Homozygous females are essentially sterile due to defects in vitellogenesis.

    Supernumerary R7 cells and extra wing veins.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    rlSu23 has visible | dominant phenotype, enhanceable by cln[+]/clnSF3-2

    Enhancer of
    Statement
    Reference

    rlSu23/rl[+] is an enhancer of visible phenotype of rgγ3

    NOT Enhancer of
    Statement
    Reference
    Suppressor of
    NOT Suppressor of
    Statement
    Reference
    Other
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    rlSu23 has wing phenotype, enhanceable by cln[+]/clnSF3-2

    rlSu23 has wing vein | ectopic phenotype, enhanceable by cln[+]/clnSF3-2

    rlSu23 has wing vein phenotype, enhanceable by Df(2R)rl10b

    Suppressed by
    Statement
    Reference

    rlSu23 has phenotype, suppressible by aoshs.PSa

    Suppressor of
    Statement
    Reference

    rlSu23 is a suppressor of phenotype of sevunspecified

    rlSu23, rl[+], rl+ is a suppressor of imaginal disc | somatic clone | larval stage phenotype of Dsor1r1

    rlSu23, rl[+], rl+ is a suppressor of imaginal disc | somatic clone | larval stage phenotype of Dsor1Gp158

    rlSu23 is a suppressor of eye phenotype of hidGMR.PG/WGMR.PG

    rlSu23 is a suppressor of eye disc phenotype of hidGMR.PG/WGMR.PG

    rlSu23 is a suppressor of phenotype of aoshs.PSa

    NOT Suppressor of
    Statement
    Reference

    rlSu23 is a non-suppressor of embryo | posterior phenotype of fs(1)M31901

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The heterozygous phenotype is enhanced by one copy of clnSF3-2.

    Fully suppresses the phl1 phenotype in terms of viability and the morphologies of the eye and wing veins. The extra wing vein and eye phenotypes of rlSu23/+ flies are significantly enhanced by Df(2R)rl10b or rl1. The posterior defects of embryos derived from homozygous fs(1)M31901 females is not suppressed if the females are also carrying one copy of rlSu23. Enhances the tor11D phenotype; considerable numbers of embryos laid by females heterozygous for rlSu23 and tor11D fail to hatch at 28oC. Dominantly suppresses the proliferation defects seen in homozygous phl1, Dsor1Gp158 or Dsor1r1 clones in imaginal discs.

    Suppresses the reduced-eye and increased cell death phenotypes of WGMR.PG.

    Phenotype can be suppressed by P{hs-argos.S}.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    The mutation in rlSu23 is identical to that found in rlSem.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    rlSu23
    Name Synonyms
    Secondary FlyBase IDs
      References (7)