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General Information
Symbol
Dmel\scase-1
Species
D. melanogaster
Name
FlyBase ID
FBal0046404
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ase1, sc2
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion in the sc regulatory region.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

scase-1 mutant fles exhibit defects in mechanosensory bristles, including a split shaft, two to three shafts arising from a single socket, an empty socket or a complete duplication.

Mutants show loss of the postvertical and scutellar bristles.

In female D.simulans/D.melanogaster hybrids heterozygous for scase-1 the anterior scutellar bristle, posterior scutellar bristle, anterior dorsocentral bristle and the posterior dorsocentral bristle are lost at a high frequency compared to female D.simulans/D.melanogaster hybrid controls, when grown at 18oC.

The number of bractless bristles on the basitarsi of the second legs is reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of aseScer\UAS.cBa under the control of Scer\GAL4hs.PB suppresses the mechanosensory bristle defects found in scase-1 mutants. The number of defective bristles in scase-1 flies is reduced from an average of 9.7 to 2.5 bristles per fly.

Overexpression of tupdsRNA.Scer\UAS under the control of Scer\GAL4pnr-MD237 in a scase-1 mutant background does not lead to the formation of supernumerary scutellar bristles.

No significant increase in the number of scutellar bristles above the scase-1 background is observed when tupex4 clones are induced in a scase-1 mutant background.

Df(1)ase-1 ; mod(mdg4)ul/mod(mdg4)ul animals show loss of a number of bristles. Bristle pigmentation is normal in these animals.

The addition of scase-1/Y to h41/+, ttkrM730/+ animals leads to a complete suppression of the ectopic margin bristle phenotype.

The addition of scase-1 strongly enhances the neuronal differentiation defects seen in Df(2R)Jp7/Df(2R)Jp8 embryos. Occasionally it appeared that the scolopale cell was inappropriately stained with neuronal markers. Some cells staining for neuronal markers appear to have lost their distinctive neuronal morphology. These embryos also had defects not seen in Df(2R)Jp7/Df(2R)Jp8 or scase-1 embryos. Neurons of the dorsal and lateral sensory neuron groups have poorly formed or misrouted axons, and in extreme cases axons are entirely missing.

Xenogenetic Interactions
Statement
Reference

Expression of Tcas\aseScer\UAS.cAa under the control of Scer\GAL4hs.PB suppresses the mechanosensory bristle defects found in scase-1 mutants. The number of defective bristles in scase-1 flies is reduced from an average of 9.7 to 4.9 bristles per fly.

Expression of Zzzz\ASH2Scer\UAS.cAa under the control of Scer\GAL4hs.PB suppresses the mechanosensory bristle defects found in scase-1 mutants. The number of defective bristles in scase-1 flies is reduced from an average of 9.7 to 3.9 bristles per fly.

Complementation and Rescue Data
Not rescued by
Comments

Expression of scScer\UAS.cUa under the control of Scer\GAL4hs.PB fails to rescue the mechanosensory bristle defects found in scase-1 mutants.

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Dubinin, 1928.

Comments
Comments

The adult phenotype of Df(1)ase-1, except for the mechanosensory bristle aspect, is due to a perturbation of the nearby sc gene: the defect is not complemented by sc10-1. The mechanosensory bristle aspect of the phenotype is rescued by the P{ase-G:4.8} and P{ase-G:3.5} constructs. The ventral sensillum campaniformium phenotype is partly rescued.

See also description under Df(1)ase-1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (13)