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General Information
Symbol
Dmel\scwE1
Species
D. melanogaster
Name
FlyBase ID
FBal0046423
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C19700652T
Reported nucleotide change:
C271T
Amino acid change:
R91C | scw-PB; R91C | scw-PA
Reported amino acid change:
R91C
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: R91C.
Nucleotide substitution: C271T.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Transheterozygotes with scwE1R1 exhibit complete failure of head involution, internalised posterior structures and reduction in the amount of dorsal ectoderm.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
scwE1 is an enhancer of phenotype of dpphr4
Additional Comments
Genetic Interactions
Statement
Reference
sax1 heterozygous mothers generate synthetic lethality when crossed to scwE1/+ males. sax2 heterozygous mothers generate synthetic lethality when crossed to scwE1/+ males. saxP heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.
Phenotype strongly enhanced by Df(2R)Pcl11B and Df(3L)66C-G28. Enhancement acts with a maternal effect.
Zygotic lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, the interaction engenders loss of amnioserosa as severe as the dpphr4 homozygous phenotype. The interaction with dpp can be reverted without losing homozygous lethality.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
Mutation is either antimorphic against dpp (if dpp and scw normally act in the same pathway) or neomorphic (if dpp and scw normally act in parallel pathways). Similar dorsal-ventral patterning defects suggest the genes act in the same pathway.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)