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General Information
Symbol
Dmel\scwE2
Species
D. melanogaster
Name
FlyBase ID
FBal0046426
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes with Df(2L)OD16 exhibit partial head involution and limited loss of dorsal tissue. Embryo also have a 'tail-up' phenotype and the posterior spiracles are disorganised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

scwE2 has lethal phenotype, suppressible | partially by Dp(2;2)DTD48

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

scwE2 is an enhancer of phenotype of dpphr4

Additional Comments
Genetic Interactions
Statement
Reference

sax1 heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.

sax2 heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.

saxP heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.

Lethal when in trans to scw- mutation. This lethality can be partially rescued by one extra copy of dpp+ (Dp(2;2)DTD48, dppd-ho). Zygotic lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Mutation is either antimorphic against dpp (if dpp and scw normally act in the same pathway) or neomorphic (if dpp and scw normally act in parallel pathways). Similar dorsal-ventral patterning defects suggest the genes act in the same pathway.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)