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General Information
Symbol
Dmel\tldE1
Species
D. melanogaster
Name
FlyBase ID
FBal0046586
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T24749978G

Amino acid change:

I61M | tld-PA

Reported amino acid change:

I51M

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two mutations in this strain.

point mutation
Nucleotide change:

T24750900A

Amino acid change:

Y282N | tld-PA

Reported amino acid change:

Y272N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two mutations in this strain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Y272N. Amino acid replacement: I51M.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryonic lethal when transheterozygous with tld- mutations.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

tldE1 is an enhancer of phenotype of dpphr4

Other
Additional Comments
Genetic Interactions
Statement
Reference

Lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. dpphr4/dpp+;tldE1/tld+ embryos completely fail to involute the head structures and is missing portions of the head skeleton. Posterior most structures including the filzkorper are internal, presumably due to the failure of germband retraction.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
tldE1
Name Synonyms
Secondary FlyBase IDs
    References (1)