|Feature type||allele||Associated gene||Dmel\tra|
|Also Known As||unspecified|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
XX flies homozygous for tra[unspecified] develop as 'pseudo-males' and are essentially indistinguishable from males in morphology and behavior but are sterile.
Heterozygous adults have normal sexual differentiation.
XX dsf- tra- animals show the ventral abdominal muscle innervation phenotype, while their XX dsf+ tra- siblings do not, indicating that dsf acts downstream of tra.
SxlM1/X ; traunspecified/traunspecified and SxlM4/X ; traunspecified/traunspecified larvae have gonads that are indistinguishable from XX ; traunspecified/traunspecified larvae. SxlM1/X ; traunspecified/traunspecified and SxlM4/X ; traunspecified/traunspecified adult pseudomales often have degenerating cells in the testes. Germ cells in these flies can be either oogenic or spermatogenic (a single animal contains only oogenic or spermatogenic testes, not both).
XX homozygotes have male internal genitalia.
Chromosomal females (XX) homozygous for traunspecified are transformed into "pseudomales". They are sterile even in the presence of a Y chromosome. The gonads form testes which are generally non-gametogenic, containing degenerated germ cells and debris or gonial cells whose sex cannot be determined. A variable proportion are gametogenic, containing either oogenic or spermatogenic stages of germ cell development (never both in the same gonad). In these cases oogenesis is arrested anywhere between stages S3 and S10A, and spermatogenesis is frequently arrested at the spermatocyte stage, although some later stages of spermatogenic differentiation are seen. Triploid intersexes with a chromosome ratio of 2X:3A are transformed to pseudomales in animals in which all three copies of tra are mutant. The gonads form well developed and nicely coiled testes, which are mostly filled with spermatogenic germ cells which were usually arrested at the spermatocyte stage.
|Phenotype Manifest In|
XX ; traunspecified/+ adults that are also carrying either Doaunspecified/DoaDem or Doaunspecified/Doa7 are clearly intersexual with respect to the number or morphology of sex combs. XX ; Doaunspecified traunspecified/DoaDem + adults have genitalia which have characteristics of both sexes, including male-like clasper bristles and anal pads. Pigmentation of abdominal tergites is intermediate to that of the normal male and female phenotypes.
Expression of Ccap\trahs.PP using heat shock in XX ; traunspecified animals results in the development of rudimentary or even almost-normal ovaries. However, these animals fail to lay eggs. XY ; Ccap\trahs.PP traunspecified animals are transformed into somatic females at 25oC (as occurs in XY ; Ccap\trahs.PP animals). However, these individuals have either malformed testes, or lack internal genitalia.
|Complementation & Rescue Data|
|Partially rescued by|
|Not rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 14 )|