|Feature type||allele||Associated gene||Dmel\wg|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: R250@.
Amino acid replacement: R250@. Nonsense mutation roughly halfway through the coding region at the end of a highly conserved region that includes 5 conserved Cys residues.
|Phenotype Manifest In|
Mutant embryos exhibit a strong loss of cluster II slou expressing muscle founder cells and of cluster I slou expressing muscle founder cells.
When hemizygous, shows patterning defects evident in the denticle belts.
Embryos exhibit naked cuticle with little denticle diversity.
|Phenotype Manifest In|
wgPE4 has embryonic/first instar larval cuticle phenotype, suppressible | maternal effect by ElfLR16/Elf[+]
wgPE4 has embryonic/first instar larval cuticle phenotype, suppressible | maternal effect by eRF1KY7/eRF1[+]
|NOT suppressed by|
wgPE4/wgDE has embryo | segment polarity expression pattern phenotype, non-suppressible by Df(3L)H99
The lawn of denticles phenotype seen in homozygous wgPE4 embryos at 25oC is suppressed by eRF1KY7 or ElfLR16. In both cases, this effect is a dominant maternal effect; wgPE4 homozygous embryos laid by a female heterozygous for wgPE4 and one of the suppressor mutations show suppression of the wgPE4 phenotype, whether or not the male parent carries the suppressor mutation. The wgPE4 phenotype is suppressed more completely in wgPE4 homozygous embryos derived from females carrying both eRF1KY7 and ElfLR16.
Heterozygosity or homozygosity for Df(3L)H99 does not result in noticeable suppression of the wgPE4/wgDE segment polarity phenotype, and there is no noticeable increase in denticle number.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 11 )|
|Personal communication to FlyBase|