Allele Dmel\y⁶⁹

General Information
Symbol	Dmel\y⁶⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0046856
Feature type	allele	Associated gene	Dmel\y

Allele class	amorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Geyer et al., 1990)
Mutagen	spontaneous (Geyer et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	y² (Geyer et al., 1990, Georgiev and Corces, 1995, Morris et al., 1999)
Nature of the lesion	Statement Reference Deletion of nucleotide 1 to 653 of gypsy, including the 5' LTR and part of the transcribed untranslated region but not including the 12 copies of the su(Hw) binding site. (Georgiev and Corces, 1995) Deletion of both gypsy sequences (removing the gypsy 5' LTR) and the y promoter and entire coding region. The first breakpoint is in the internal portion of gypsy at +653bp (gypsy coordinates as in FBrf0045014), and the second breakpoint is located immediately 3' to the y gene. The second breakpoint brings gypsy sequences next to the 3' region of a jockey element located 3' to y. (Geyer et al., 1990)
Caused by insertion	gypsy{3'}y⁶⁹ (Geyer et al., 1990, Georgiev and Corces, 1995)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	antenna (Georgiev and Corces, 1995) leg & macrochaeta (Georgiev and Corces, 1995) microchaeta (Georgiev and Corces, 1995)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference y⁶⁹ has visible \| dominant phenotype, enhanceable by mod(mdg4)^ul (Georgiev and Corces, 1995)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	y²³⁷⁴ (Morris et al., 1999)
Fails to complement	y² (Morris et al., 1999) y^59b (Morris et al., 1999) y^62a (Morris et al., 1999) y^82f29 (Morris et al., 1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Arose in: mu1 background. (Geyer et al., 1990)
Comments
	"y²" was stated as tentative. (Morris et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	y⁶⁹
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Morris et al., 1999, Genetics 151(2): 633--651 An analysis of transvection at the yellow locus of Drosophila melanogaster. [FBrf0106981] Georgiev and Corces, 1995, Proc. Natl. Acad. Sci. U.S.A. 92(11): 5184--5188 The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog. [FBrf0082023] Geyer et al., 1990, EMBO J. 9: 2247--2256 Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromosome: the molecular basis of transvection in Drosophila. [FBrf0051634]
Review	Duncan, 2002, A. Rev. Genet. 36: 521--556 Transvection effects in Drosophila. [FBrf0151731]

Allele Dmel\y69

Allele Dmel\y⁶⁹