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General Information
Symbol
Dmel\Nup154zk-1
Species
D. melanogaster
Name
FlyBase ID
FBal0046893
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion approximately 100bp upstream from the start of the predicted Nup154 open reading frame. The insertion is in the same 5' to 3' orientation as the direction of Nup154 transcription.

Insertion components
P{lacW}Nup154zk-1
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous females have tiny ovaries which almost completely lack egg chambers beyond oogenic stage 7. Most early, vitellogenic egg chambers have nurse cells and a single oocyte. Egg chambers in which the oocyte has begun to take up yolk are seen but are rare. Occasionally egg chambers contain two oocytes, which are always located at nearly opposite poles of the egg chamber. Approximately once per ovary, an egg chamber has twice the normal number of nuclei. Older egg chambers appear to degenerate. Homozygous, Nup154zk-1/Nup154k07701b and hemizygous males have tiny testes which appear to contain no germ cells. Some germ cells are occasionally present in homozygous larval gonads, unlike the completely empty adult testes. However, very few germ cells per testis are seen (usually 0-10 cells) and the germ cells present are spermatocytes not organised into normal germline cysts. Small cells present at the apical tip in wild type are absent in mutants, suggesting absence of renewing germline during late larval stages. Nup154zk-1/Nup15410432 males have an "intermediate" testis phenotype with what appear to be degenerating germ cells and occasional spermatocytes.

Males have tiny testis due to an absence of developing germline.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The male and female sterility phenotypes of Nup154zk-1 are reverted upon excision of the P{lacW} element.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)