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General Information
Symbol
Scer\GAL4Toll-6-D42
Species
S. cerevisiae
Name
FlyBase ID
FBal0047062
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
D42-Gal4, D42, D42 Gal4, D42Gal4, GAL4-D42, P[GawB]D42
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
(Kang et al., 2020, Bruels et al., 2019, Donde et al., 2019, Dulovic-Mahlow et al., 2019, François-Moutal et al., 2019, Guo et al., 2019, Kim et al., 2019, Lembke et al., 2019, Li et al., 2019, Liu et al., 2019, Lu et al., 2019, Manzo et al., 2019, Peng et al., 2019, Trostnikov et al., 2019, Tsakiri et al., 2019, Xiao and Qiu, 2019, Xiao et al., 2019, Xu et al., 2019, Zhang et al., 2019, Bogaert et al., 2018, Fedotov et al., 2018, Garcia-Lopez et al., 2018, Heo et al., 2018, Jantrapirom et al., 2018, Liu et al., 2018, Mallik et al., 2018, Mattingly et al., 2018, Migh et al., 2018, Pareek et al., 2018, Seong et al., 2018, Straub et al., 2018, Suda et al., 2018, Tran et al., 2018, Xu and Xu, 2018, Yamamoto et al., 2018, Aguilar et al., 2017, Alicea et al., 2017, Arnés et al., 2017, Casas-Tintó et al., 2017, De Rose et al., 2017, Gregory et al., 2017, Hautbergue et al., 2017, Hosaka et al., 2017, Inoshita et al., 2017, Laneve et al., 2017, Lembke et al., 2017, Li et al., 2017, Lo Piccolo and Yamaguchi, 2017, Raut et al., 2017, Ruppert et al., 2017, Santana and Casas-Tintó, 2017, Ulian-Benitez et al., 2017, Vanhauwaert et al., 2017, Wang et al., 2017, Yoon et al., 2017, Yoon et al., 2017, Altanbyek et al., 2016, Baldwin et al., 2016, Boeynaems et al., 2016, Chao et al., 2016, Chen et al., 2016, Choudhury et al., 2016, Clark et al., 2016, Colomb and Brembs, 2016, Harel et al., 2016, MacNamee et al., 2016, Mushtaq et al., 2016, Quraishe et al., 2016, Slabbaert et al., 2016, Soukup et al., 2016, Summerville et al., 2016, Wang et al., 2016, Beck et al., 2015, Butzlaff et al., 2015, Cagin et al., 2015, Chen et al., 2015, Cheng et al., 2015, Chou et al., 2015, Cowan et al., 2015, Coyne et al., 2015, Deng et al., 2015, Di Salvio et al., 2015, Hagel et al., 2015, Jäckel et al., 2015, Joardar et al., 2015, Kim et al., 2015, Lu et al., 2015, Niehues et al., 2015, Pech et al., 2015, Peng et al., 2015, Petrosyan et al., 2015, Ward et al., 2015, Yang et al., 2015, Chang et al., 2014, Chen et al., 2014, Coyne et al., 2014, Ehaideb et al., 2014, Faust et al., 2014, Godena et al., 2014, Harwood et al., 2014, James et al., 2014, Janssens et al., 2014, Li et al., 2014, Lüchtenborg and Katanaev, 2014, Mishra-Gorur et al., 2014, Miskiewicz et al., 2014, Moreau et al., 2014, Moustaqim-Barrette et al., 2014, Sandoval et al., 2014, Titlow et al., 2014, Vasmer et al., 2014, Bahadorani et al., 2013, Borg and Cauchi, 2013, Chang et al., 2013, Estes et al., 2013, Ihara et al., 2013, Johnson et al., 2013, Kern et al., 2013, Kitay et al., 2013, Lu et al., 2013, McIlroy et al., 2013, Quraishe et al., 2013, Rahman et al., 2013, Sinadinos et al., 2013, Vanden Broeck et al., 2013, Vonhoff et al., 2013, Zhan et al., 2013, Zhu et al., 2013, Bayat et al., 2012, Beck et al., 2012, Couthouis et al., 2012, Djagaeva et al., 2012, Füger et al., 2012, Gregory et al., 2012, Hazelett et al., 2012, Holbrook et al., 2012, Kim et al., 2012, Lee et al., 2012, Mozer and Sandstrom, 2012, Nechipurenko and Broihier, 2012, Pradhan et al., 2012, Rawson et al., 2012, Ruiz et al., 2012, Ryglewski et al., 2012, Tsai et al., 2012, Xia et al., 2012, Zhou et al., 2012, Chun-Jen Lin et al., 2011, Couthouis et al., 2011, Estes et al., 2011, Freeman et al., 2011, Godena et al., 2011, Iyengar et al., 2011, James and Broihier, 2011, Jepson et al., 2011, Keegan et al., 2011, Kucherenko et al., 2011, Lin et al., 2011, Liu et al., 2011, Rossetto et al., 2011, Schultz et al., 2011, Stavropoulos and Young, 2011, Yao et al., 2011, Zhong et al., 2011, Bahadorani et al., 2010, Batlevi et al., 2010, Boerner and Duch, 2010, Cowan et al., 2010, Crocker et al., 2010, Elden et al., 2010, Folwell et al., 2010, Hanson et al., 2010, Khuong et al., 2010, Lone et al., 2010, Lorenzo et al., 2010, Melicharek et al., 2010, Nedelsky et al., 2010, Owald et al., 2010, Pathak et al., 2010, Radyuk et al., 2010, Shidara and Hollenbeck, 2010, Voigt et al., 2010, Vonhoff and Duch, 2010, Barber et al., 2009, Dason et al., 2009, Feiguin et al., 2009, Fischer et al., 2009, Kissler et al., 2009, Li and Tower, 2009, Martin et al., 2009, Morais et al., 2009, Orso et al., 2009, Sanyal, 2009, Barkus et al., 2008, Cauchi et al., 2008, Chai et al., 2008, Kwak et al., 2008, Legan et al., 2008, Watson et al., 2008, Ford et al., 2007, Haghnia et al., 2007, Huang and Haddad, 2007, Lissandron et al., 2007, Llorens et al., 2007, Romero-Pozuelo et al., 2007, Wu et al., 2007, Xiao et al., 2007, Grammenoudi et al., 2006, Lind et al., 2006, Martin-Pena et al., 2006, Pilling et al., 2006, Schroll et al., 2006, Walker, 2006, Walker et al., 2006, Anderson et al., 2005, Bronk et al., 2005, Hebbar and Fernandes, 2005, Horiuchi et al., 2005, Houseley et al., 2005, Miller et al., 2005, Orr et al., 2005, Verstreken et al., 2005, Yoshihara et al., 2005, Zheng et al., 2005, Broughton et al., 2004, Mudher et al., 2004, Rogina and Helfand, 2004, Suster et al., 2004, Kuniyoshi et al., 2003, Landgraf et al., 2003, Missirlis et al., 2003, Morey et al., 2003, Chan et al., 2002, Marek and Davis, 2002, Nitz et al., 2002, Seroude et al., 2002, Song et al., 2002, Sweeney and Davis, 2002, Taghert et al., 2001, Wittmann et al., 2001, Shayan and Atwood, 2000, Usui-Aoki et al., 2000, Cheung et al., 1999, Elia et al., 1999, Parkes et al., 1998, Gustafson and Boulianne, 1996, Yeh et al., 1995)
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{GawB} insertion approximately 1.5kb upstream of the Toll-6 transcription start site.

Insertion components
P{GawB}D42
Product class / Tool use(s)
Expression Data
Reporter Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives expression in motor neurons.

Scer\GAL4Toll-6-D42 drives expression in glomeruli of the lateral antennal lobe, which are all innervated by trichoid olfactory receptor neurons. Labeling is seen in both antennal projection and olfactory receptor neurons.

Expression is widespread in the larval ventral nerve cord including the dorsal medial cluster of motor neurons. Expression is also strong in the larval brain lobes but is absent from the optic lobes. Robust expression is seen in motor and sensory axons of the body wall.

Strong reporter expression was observed in the adult brain and weaker expression was observed in the ventral nerve cord, fat body, and oenocytes.

Scer\GAL4Toll-6-D42 is expressed in motor neurons of larvae, and is expressed within thoracic motor neurons and scattered cells throughout the brain of adults.

In late embryo, expressed in a wide range of tissues.

 
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

neuromuscular junction & abdominal 4 ventral longitudinal muscle 3 & larva, with dncUAS.cCa

neuromuscular junction & abdominal 4 ventral longitudinal muscle 4 & larva, with dncUAS.cCa

neuromuscular junction & abdominal ventral longitudinal muscle 1 & larva, with dncUAS.cCa

neuromuscular junction & abdominal ventral longitudinal muscle 2 & larva, with dncUAS.cCa

Detailed Description
Statement
Reference

Motor neuron-specific blockage of synaptic transmission by the expression of shits.UAS.cUa under the control of Scer\GAL4Toll-6-D42 at 29[o]C leads to held-up wing phenotype at low prevalence.

Optogenetic activation (using Crei\ChR2H134R.UAS.mCherry with 470 nm (blue) light) of Scer\GAL4Toll-6-D42 cells in larvae results in inward currents in astrocytes, with no effect on their level of dye-coupling, compared to controls.

Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4Toll-6-D42 cells in third instar larvae results in rapid paralysis and a shi1.UAS dose-dependent increase in the rate of loss of excitatory junction potentials from body wall muscles in response to nerve stimulation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

cacUAS.EGFP/Scer\GAL4Toll-6-D42 is a non-suppressor of lethal phenotype of TBPHG2

Scer\GAL4Toll-6-D42/Frq2UAS.cRPa is a non-suppressor of neurophysiology defective | temperature conditional phenotype of cacTS2

Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

NFATEP1508, Scer\GAL4Toll-6-D42 has synapse phenotype, suppressible by futschN94/futsch[+]

NFATEP19579, Scer\GAL4Toll-6-D42 has synapse phenotype, suppressible by futschN94/futsch[+]

NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescues
Partially rescues
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
GAL4D42
Scer\GAL4D42
Scer\GAL4Toll-6-D42
Name Synonyms
Secondary FlyBase IDs
    References (250)