FB2025_01 , released February 20, 2025
Allele: Scer\GAL4Toll-6-D42
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General Information
Symbol
Scer\GAL4Toll-6-D42
Species
S. cerevisiae
Name
FlyBase ID
FBal0047062
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
D42-Gal4, D42, D42 Gal4, D42Gal4, GAL4-D42, P[GawB]D42
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P{GawB} insertion approximately 1.5kb upstream of the Toll-6 transcription start site.

Allele components
Component
Use(s)
Inserted element
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
(Koch and Nagoshi, 2025, Banerjee et al., 2024, Chitre et al., 2024, Droppelmann et al., 2024, Ehweiner et al., 2024, Glineburg et al., 2024, Hendricks and Liebl, 2024, Ikeda et al., 2024, Li et al., 2024, Rankin et al., 2024, Smith et al., 2024, Tziortzouda et al., 2024, Wang et al., 2024, Yang et al., 2024, Yeewa et al., 2024, Bennett et al., 2023, Castelli et al., 2023, Ervilha Pereira et al., 2023, Han et al., 2023, Kang et al., 2023, Katarachia et al., 2023, Kim et al., 2023, Kour et al., 2023, Lo Piccolo et al., 2023, Mann et al., 2023, Pérez-Moreno et al., 2023, Son et al., 2023, Stubbs et al., 2023, Waller and Collins, 2023, Zhao et al., 2023, Bosch et al., 2022, Cha et al., 2022, Chakravorty et al., 2022, Del Castillo et al., 2022, Grice and Liu, 2022, Han et al., 2022, Hanson and Lemaitre, 2022, Hernandez-Diaz et al., 2022, Hura et al., 2022, Inoshita et al., 2022, Kishino et al., 2022, Loganathan et al., 2022, Molnar et al., 2022, Xu et al., 2022, Aragão Gomes et al., 2021, Bakkar et al., 2021, Blázquez-Bernal et al., 2021, Budnar et al., 2021, Castelli et al., 2021, Choi et al., 2021, Coni et al., 2021, Cowan et al., 2021, Even et al., 2021, Florian et al., 2021, Gunaseelan et al., 2021, Hengel et al., 2021, Hurley and Staveley, 2021, Insolera et al., 2021, Jarabo et al., 2021, Kim et al., 2021, Kim et al., 2021, Krick et al., 2021, Lehmkuhl et al., 2021, Lin et al., 2021, Lund et al., 2021, Odnokoz et al., 2021, Park et al., 2021, Wong et al., 2021, Balasov et al., 2020, Balasubramanian and Srinivasan, 2020, Basargekar et al., 2020, Cha et al., 2020, Heinrich and Ryglewski, 2020, Ibrahim et al., 2020, Kang et al., 2020, Kiragasi et al., 2020, Konieczny and Artero, 2020, Martin-Peña and Ferrus, 2020, Montagna et al., 2020, Norkett et al., 2020, Palazzo et al., 2020, Park et al., 2020, Patel et al., 2020, Pirooznia et al., 2020, Santana et al., 2020, Singh et al., 2020, Wang et al., 2020, Wang et al., 2020, White et al., 2020, Yalgin et al., 2020, Yu et al., 2020, Zhang et al., 2020, Zhang et al., 2020, Zhao et al., 2020, Bruels et al., 2019, Casci et al., 2019, Donde et al., 2019, Drelon et al., 2019, Dulovic-Mahlow et al., 2019, Espadas et al., 2019, François-Moutal et al., 2019, Gong et al., 2019, Guo et al., 2019, Hao et al., 2019, Hunt et al., 2019, Imai et al., 2019, Kim et al., 2019, Konrad et al., 2019, Lembke et al., 2019, Li et al., 2019, Liu et al., 2019, Lu et al., 2019, Manzo et al., 2019, Peng et al., 2019, Politano et al., 2019, Portela et al., 2019, Trostnikov et al., 2019, Tsakiri et al., 2019, Vajente et al., 2019, Xiao and Qiu, 2019, Xiao et al., 2019, Xiao et al., 2019, Xu et al., 2019, Zhang et al., 2019, Azpurua et al., 2018, Bogaert et al., 2018, Duncan et al., 2018, Fedotov et al., 2018, Garcia-Lopez et al., 2018, Heo et al., 2018, Jantrapirom et al., 2018, Jonson et al., 2018, Lauwers et al., 2018, Liu et al., 2018, Maccioni et al., 2018, Mallik et al., 2018, Mattingly et al., 2018, McInnes et al., 2018, Migh et al., 2018, Pareek et al., 2018, Romano et al., 2018, Seong et al., 2018, Steyaert et al., 2018, Straub et al., 2018, Suda et al., 2018, Tran et al., 2018, Xu and Xu, 2018, Yamamoto et al., 2018, Aguilar et al., 2017, Alicea et al., 2017, Arnés et al., 2017, Barwell et al., 2017, Casas-Tintó et al., 2017, Coyne et al., 2017, De Rose et al., 2017, Gregory et al., 2017, Hautbergue et al., 2017, Hosaka et al., 2017, Inoshita et al., 2017, Laneve et al., 2017, Lembke et al., 2017, Li et al., 2017, Liu et al., 2017, López-Arias et al., 2017, Lo Piccolo and Yamaguchi, 2017, Neisch et al., 2017, Podratz et al., 2017, Raut et al., 2017, Ruppert et al., 2017, Saburova et al., 2017, San Martin et al., 2017, Santana and Casas-Tintó, 2017, Sealey et al., 2017, Ulian-Benitez et al., 2017, Vanhauwaert et al., 2017, Wang et al., 2017, Yoon et al., 2017, Yoon et al., 2017, Zhou et al., 2017, Altanbyek et al., 2016, Baldwin et al., 2016, Boeynaems et al., 2016, Chao et al., 2016, Chen et al., 2016, Choudhury et al., 2016, Clark et al., 2016, Colomb and Brembs, 2016, Harel et al., 2016, MacNamee et al., 2016, Mushtaq et al., 2016, Quraishe et al., 2016, Slabbaert et al., 2016, Soukup et al., 2016, Summerville et al., 2016, Wang et al., 2016, Zappia and Frolov, 2016, Beck et al., 2015, Butzlaff et al., 2015, Cagin et al., 2015, Chen et al., 2015, Cheng et al., 2015, Chou et al., 2015, Cowan et al., 2015, Coyne et al., 2015, Deng et al., 2015, Di Salvio et al., 2015, Hagel et al., 2015, Jäckel et al., 2015, Joardar et al., 2015, Kim et al., 2015, Lu et al., 2015, Niehues et al., 2015, Pech et al., 2015, Peng et al., 2015, Petrosyan et al., 2015, Ward et al., 2015, Yang et al., 2015, Chang et al., 2014, Chen et al., 2014, Choi et al., 2014, Coyne et al., 2014, Ehaideb et al., 2014, Faust et al., 2014, Godena et al., 2014, Harwood et al., 2014, James et al., 2014, Janssens et al., 2014, Kang et al., 2014, Li et al., 2014, Lüchtenborg and Katanaev, 2014, Lüchtenborg et al., 2014, Mishra-Gorur et al., 2014, Miskiewicz et al., 2014, Moreau et al., 2014, Moustaqim-Barrette et al., 2014, Sandoval et al., 2014, Shiraishi et al., 2014, Titlow et al., 2014, Vasmer et al., 2014, Wong et al., 2014, Bahadorani et al., 2013, Borg and Cauchi, 2013, Chang et al., 2013, Estes et al., 2013, Ihara et al., 2013, Johnson et al., 2013, Kern et al., 2013, Kitay et al., 2013, Kottler et al., 2013, Kuehn and Duch, 2013, Lu et al., 2013, McIlroy et al., 2013, Quraishe et al., 2013, Rahman et al., 2013, Sinadinos et al., 2013, Vanden Broeck et al., 2013, Vonhoff et al., 2013, Zhan et al., 2013, Zhu et al., 2013, Bayat et al., 2012, Beck et al., 2012, Couthouis et al., 2012, Djagaeva et al., 2012, Füger et al., 2012, Gregory et al., 2012, Hazelett et al., 2012, Holbrook et al., 2012, Kim et al., 2012, Lee et al., 2012, Mozer and Sandstrom, 2012, Nechipurenko and Broihier, 2012, Pradhan et al., 2012, Rawson et al., 2012, Ruiz et al., 2012, Ryglewski et al., 2012, Tsai et al., 2012, Xia et al., 2012, Zhou et al., 2012, Chun-Jen Lin et al., 2011, Couthouis et al., 2011, Estes et al., 2011, Freeman et al., 2011, Godena et al., 2011, Iyengar et al., 2011, James and Broihier, 2011, Jepson et al., 2011, Keegan et al., 2011, Kucherenko et al., 2011, Lin et al., 2011, Liu et al., 2011, Rossetto et al., 2011, Schultz et al., 2011, Stavropoulos and Young, 2011, Yao et al., 2011, Zhong et al., 2011, Bahadorani et al., 2010, Batlevi et al., 2010, Boerner and Duch, 2010, Cowan et al., 2010, Crocker et al., 2010, Elden et al., 2010, Folwell et al., 2010, Hanson et al., 2010, Khuong et al., 2010, Lone et al., 2010, Lorenzo et al., 2010, Melicharek et al., 2010, Nedelsky et al., 2010, Nojima et al., 2010, Owald et al., 2010, Pathak et al., 2010, Radyuk et al., 2010, Shidara and Hollenbeck, 2010, Voigt et al., 2010, Vonhoff and Duch, 2010, Barber et al., 2009, Dason et al., 2009, Feiguin et al., 2009, Fischer et al., 2009, Kissler et al., 2009, Li and Tower, 2009, Martin et al., 2009, Morais et al., 2009, Orso et al., 2009, Sanyal, 2009, Barkus et al., 2008, Cauchi et al., 2008, Chai et al., 2008, Kwak et al., 2008, Legan et al., 2008, Watson et al., 2008, Ford et al., 2007, Haghnia et al., 2007, Huang and Haddad, 2007, Knight et al., 2007, Lissandron et al., 2007, Llorens et al., 2007, Romero-Pozuelo et al., 2007, Wu et al., 2007, Xiao et al., 2007, Grammenoudi et al., 2006, Lind et al., 2006, Martin-Pena et al., 2006, Pilling et al., 2006, Schroll et al., 2006, Thum et al., 2006, Walker, 2006, Walker et al., 2006, Anderson et al., 2005, Bronk et al., 2005, Hebbar and Fernandes, 2005, Horiuchi et al., 2005, Houseley et al., 2005, Miller et al., 2005, Orr et al., 2005, Verstreken et al., 2005, Yoshihara et al., 2005, Zheng et al., 2005, Broughton et al., 2004, Mudher et al., 2004, Rogina and Helfand, 2004, Suster et al., 2004, Kuniyoshi et al., 2003, Landgraf et al., 2003, Missirlis et al., 2003, Morey et al., 2003, Chan et al., 2002, Marek and Davis, 2002, Nitz et al., 2002, Seroude et al., 2002, Song et al., 2002, Sweeney and Davis, 2002, Taghert et al., 2001, Wittmann et al., 2001, Shayan and Atwood, 2000, Usui-Aoki et al., 2000, Cheung et al., 1999, Elia et al., 1999, Parkes et al., 1998, Gustafson and Boulianne, 1996, Yeh et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives expression in motor neurons.

ScerGAL4Toll-6-D42 drives expression in glomeruli of the lateral antennal lobe, which are all innervated by trichoid olfactory receptor neurons. Labeling is seen in both antennal projection and olfactory receptor neurons.

Expression is widespread in the larval ventral nerve cord including the dorsal medial cluster of motor neurons. Expression is also strong in the larval brain lobes but is absent from the optic lobes. Robust expression is seen in motor and sensory axons of the body wall.

Strong reporter expression was observed in the adult brain and weaker expression was observed in the ventral nerve cord, fat body, and oenocytes.

ScerGAL4D42 is expressed in motor neurons of larvae, and is expressed within thoracic motor neurons and scattered cells throughout the brain of adults.

In late embryo, expressed in a wide range of tissues.

 
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

neuromuscular junction & abdominal 4 ventral longitudinal muscle 3 & larva, with Pde4UAS.cCa

neuromuscular junction & abdominal 4 ventral longitudinal muscle 4 & larva, with Pde4UAS.cCa

neuromuscular junction & abdominal ventral longitudinal muscle 1 & larva, with Pde4UAS.cCa

neuromuscular junction & abdominal ventral longitudinal muscle 2 & larva, with Pde4UAS.cCa

Detailed Description
Statement
Reference

Motor neuron-specific blockage of synaptic transmission by the expression of shits.UAS.cUa under the control of Scer\GAL4Toll-6-D42 at 29[o]C leads to held-up wing phenotype at low prevalence.

Optogenetic activation (using Crei\ChR2H134R.UAS.mCherry with 470 nm (blue) light) of Scer\GAL4Toll-6-D42 cells in larvae results in inward currents in astrocytes, with no effect on their level of dye-coupling, compared to controls.

Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4Toll-6-D42 cells in third instar larvae results in rapid paralysis and a shi1.UAS dose-dependent increase in the rate of loss of excitatory junction potentials from body wall muscles in response to nerve stimulation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
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Reference
Suppressed by
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NOT suppressed by
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Enhancer of
Statement
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NOT Enhancer of
Suppressor of
Statement
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NOT Suppressor of
Statement
Reference

cacUAS.EGFP/Scer\GAL4Toll-6-D42 is a non-suppressor of lethal phenotype of TBPHG2

Scer\GAL4Toll-6-D42/Frq2UAS.cRPa is a non-suppressor of abnormal neurophysiology | temperature conditional phenotype of cacTS2

Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

NFATEP1508, Scer\GAL4Toll-6-D42 has synapse phenotype, suppressible by futschN94/futsch[+]

NFATEP19579, Scer\GAL4Toll-6-D42 has synapse phenotype, suppressible by futschN94/futsch[+]

NOT suppressed by
Statement
Reference
Enhancer of
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Reference
NOT Enhancer of
Statement
Reference
Suppressor of
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NOT Suppressor of
Statement
Reference

Hsap\LRRK2G2019S.UAS.Tag:MYC/Scer\GAL4Toll-6-D42 is a non-suppressor of NMJ bouton | larval stage | nutrition conditional phenotype of EndoB4

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescues
Partially rescues
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
GAL4D42
Scer\GAL4D42
Scer\GAL4Toll-6-D42
Name Synonyms
Secondary FlyBase IDs
    References (384)