FB2025_01 , released February 20, 2025
Allele: Ecol\lacZE(spl)m8-HLH.-1166+87
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General Information
Symbol
Ecol\lacZE(spl)m8-HLH.-1166+87
Species
E. coli
Name
FlyBase ID
FBal0047360
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{m8-lacZ}
Also Known As
E(spl)m8-lacZ, m8-lacZ, E(spl)m8 lacZ
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lecourtois and Schweisguth, 1995)
Progenitor genotype
Carried in construct
P{m8-lacZ}
Cytology
Description

E(spl)m8-HLH promoter fragment extending from -1166 to +87 drives expression of lacZ.

(Lecourtois and Schweisguth, 1995)
Allele components
Component
Use(s)
Regulatory region(s)
E(spl)m8-HLH_-1166/+87
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 8 -- 10
      ventral nerve cord primordium
      (Lecourtois and Schweisguth, 1995)
      embryonic stage 9
      stage 1 neuroblast
      (Lecourtois and Schweisguth, 1995)
      embryonic stage 12
      ventral neurectoderm
      (Monastirioti et al., 2010)
      third instar larval stage
      proneural cluster
      (Shukla et al., 2017)
      wandering third instar larval stage
      anterior-posterior compartment boundary of the wing disc
      (Klein, 2003)
      presumptive wing vein L3
      (Klein, 2003)
      Additional Information
      Statement
      Reference

      In stage 9 embryo, expressed in two longitudinal rows of ectodermal cells on either side of the ventral midline and in some additional cells located between these two rows; also expressed in delaminating SI neuroblasts.

      (Lecourtois and Schweisguth, 1995)
       
      Marker for
      proneural cluster
      (Shukla et al., 2017)
      Reflects expression of
      E(spl)m8-HLH
      (Shukla et al., 2017, Klein, 2003)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ecol\lacZE(spl).-1166+87
      Ecol\lacZE(spl)m8-HLH.-1166+87
      lacZE(spl).-1166+87
      Name Synonyms
      Secondary FlyBase IDs
        References (26)