FB2025_01 , released February 20, 2025
Allele: Ecol\lacZdpp-10638
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General Information
Symbol
Ecol\lacZdpp-10638
Species
E. coli
Name
FlyBase ID
FBal0047652
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
P{PZ}dpp10638
Carried in Construct
Also Known As
Dpp-LacZ, dpp10638, dppP10638, dpp-lacZ10638, dpp-lacZP10638, dpp10638-lacZ, dppZ
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kopp et al., 1997, Schneider and Spradling, 1997, Struhl et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}dpp10638
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
transposable_element_insertion_site
2L:2,454,515..2,454,515 [+]
(Ahmed-de-Prado et al., 2024, Saad and Hipfner, 2021, Rust et al., 2020, Takemura et al., 2020, Zappia et al., 2020, Praktiknjo et al., 2018, Xu et al., 2018, Dahal et al., 2017, Requena et al., 2017, Maier et al., 2014, Roy et al., 2014, Guo et al., 2013, Li et al., 2013, Li et al., 2013, Paul et al., 2013, Peterson and O'Connor, 2013, Pitsouli and Perrimon, 2013, Wojcinski et al., 2011, Casali, 2010, Cheng et al., 2010, Ninov et al., 2010, Yan et al., 2010, Yan et al., 2009, Zhang et al., 2009, Cordero et al., 2007, Grammont, 2007, Callejo et al., 2006, Crickmore and Mann, 2006, Crickmore and Mann, 2006, de Navas et al., 2006, Poulton and Deng, 2006, Wehn and Campbell, 2006, Yasunaga et al., 2006, Panakova et al., 2005, Rogulja and Irvine, 2005, Kankel et al., 2004, Kato et al., 2004, Kwon et al., 2004, Ryoo et al., 2004, Torroja et al., 2004, Wilk et al., 2004, Farge, 2003, Xi et al., 2003, Crack et al., 2002, Micchelli et al., 2002, Briscoe et al., 2001, Hasson et al., 2001, Lefers et al., 2001, Methot and Basler, 2001, Reed et al., 2001, Suzanne et al., 2001, Campbell and Tomlinson, 2000, Cavodeassi et al., 2000, Dobens et al., 2000, Methot and Basler, 2000, Miletich and Limbourg-Bouchon, 2000, Tomoyasu et al., 2000, Usui and Simpson, 2000, Wehrli et al., 2000, Agnes et al., 1999, Burke et al., 1999, Campbell and Tomlinson, 1999, Cavodeassi et al., 1999, Gelbart, 1999.7.20, Hepker et al., 1999, Kopp et al., 1999, Methot and Basler, 1999, Chen and Struhl, 1998, Jackle and Janning, 1998.8.10, Schweizer and Basler, 1998, Vosshall, 1998.8.10, Goto and Hayashi, 1997, Hepker et al., 1997, Kopp et al., 1997, Schneider and Spradling, 1997, Struhl et al., 1997, Burke and Basler, 1996, Chen and Struhl, 1996, Forbes et al., 1996, Twombly et al., 1996, Jiang and Struhl, 1995, Zecca et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage
      larval brain | presumptive
      (Jackle and Janning, 1998.8.10)
      embryonic/larval anterior spiracle
      (Jackle and Janning, 1998.8.10)
      organism | segmentally repeated
      (Jackle and Janning, 1998.8.10)
      presumptive embryonic/larval peripheral nervous system | segmentally repeated
      (Jackle and Janning, 1998.8.10)
      presumptive embryonic/larval central nervous system | restricted
      (Jackle and Janning, 1998.8.10)
      embryonic stage 11
      amnioserosa
      (Reed et al., 2001)
      embryonic stage 11 -- 14
      embryonic leading edge cell
      (Reed et al., 2001)
      embryonic stage 14
      epidermis | lateral
      (Reed et al., 2001)
      second instar larval stage
      peripodial epithelium of wing disc
      (Paul et al., 2013)
      third instar larval stage
      wing disc | restricted
      (Schweizer and Basler, 1998)
      wing disc | posterior | proximal
      (Foronda et al., 2009)
      wing disc anterior compartment | restricted
      (Cheng et al., 2010)
      anterior-posterior compartment boundary of the wing disc
      (Roy et al., 2014)
      wandering third instar larval stage
      imaginal disc | restricted
      (Meister and Braun, 1995.10)
      prepupal stage P3 -- pupal stage P5
      histoblast nest | restricted
      (Ninov et al., 2010)
      histoblast | subset
      (Ninov et al., 2010)
      adult stage
      anterior-posterior compartment boundary of the wing blade
      (Foronda et al., 2009)
      axillary cord
      (Foronda et al., 2009)
      Additional Information
      Statement
      Reference

      dpp reporter is barely expressed in anterior and posterior dorsal nests histoblasts at 4-6h APF and not at all in surrounding LECs. Only a small group of cells in the ventral nest begin to express at this stage. During the onset of histoblast expansion (16-17h APF), dpp-LacZ is expressed in discrete dorsal cells from the anterior dorsal and ventral nest. In addition, dpp reporter is upregulated in most larval epidermal cells surrounding each of the four nests.

      (Ninov et al., 2010)

      In addtion to expression anterior to and close to the A/P boundary of third instar wing discs, dpp reporter expression is observed in a proximal region of the posterior compartment beginning in the mid-third-instar larval stage. In the adult wing, staining is observed along the A/P border and in the axillary cord but not in the alula.

      (Foronda et al., 2009)

      dppFBtr0091350:pb-XREcollacZexpression pattern in the wing disc is restricted to a stripe of cells alongthe antrior-posterior compartment boundary.

      (Schweizer and Basler, 1998)

      In embryo, expression in anterior spiracles and in PNS not certain.

      (Jackle and Janning, 1998.8.10)
       
      Marker for
      amnioserosa
      (Reed et al., 2001)
      anterior-posterior compartment boundary of the wing disc
      (Roy et al., 2014)
      embryonic leading edge cell
      (Reed et al., 2001)
      Reflects expression of
      dpp
      (Roy et al., 2014, Paul et al., 2013, Ninov et al., 2010, Foronda et al., 2009, Reed et al., 2001, Schweizer and Basler, 1998)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Dadj1E4
      (Zappia et al., 2020)
      Ecol\lacZdpp-10638
      dpp10638
      (Praktiknjo et al., 2018, Torroja et al., 2004, Xi et al., 2003, Micchelli et al., 2002)
      dpp10638lacZ
      (Cummins et al., 2003)
      dppP10638
      (Xu et al., 2018, Methot and Basler, 2000, Tomoyasu et al., 2000)
      lacZdpp-10638
      Name Synonyms
      Secondary FlyBase IDs
        References (86)