|Feature type||allele||Associated gene||Dmel\CASK|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by aberration|
|Phenotype Manifest In|
Mature CASK[X-307]/CASK[X-313] males show a extremely low overall level of immature-male courtship than the control. Courtship initiation latency of this mutant is also significantly longer than the control, with many males never initiating courtship during a 10 minute observation. Mature CASK[X-307]/CASK[X-313] males fail to habituate to immature male pheromones. CASK[P18]/CASK[X-307] flies exhibit significantly less movement than control flies. CASK[X-307]/CASK[X-313] flies exhibit significantly less movement than control flies. CASK[X-307]/CASK[X-313] flies have normal circadian locomotor rhythms and wild type free running periods.
CASK[X-307]/CASK[X-313] mutant flies exhibit an impairment in their flight ability compared to wild-type flies. Indirect flight muscle action potentials display significantly longer short- and long-latencies compared to wild-type controls. In some indirect flight muscles (approximately 5%) displaying a normal resting membrane potential, the stimulation of the giant fiber pathway fails to evoke a clear repsonse, which intead appears as a small depolarization. This lack of response remains unchanged with time as well as with increasing stimulus voltage or duration, suggesting that synaptic transmission is impaired in these fibers. The ability of the giant fiber pathway to follow continuous stimulation is also impaired. In contrast to wild-type flies, short-latency responses show a significant response decrement even at low stimulation frequencies in CASK[X-307]/CASK[X-313] mutant flies. Long-latency responses show habituation, as in wild-type. At stimulation frequencies between 1 and 3 Hz the onset of habituation occurs significantly earlier in CASK[X-307]/CASK[X-313] mutant flies than in wild-type. The percentage of CASK[X-307]/CASK[X-313] mutant flies that show habituation is lower than in wild-type controls. These flies are also less responsive to dishabituation. The resting membrane potential of indirect flight muscle fibers from CASK[X-307]/CASK[X-313] mutant flies is not significantly different from wild-type. Average miniature end-plate potentials (MEPPs) frequency in CASK[X-307]/CASK[X-313] mutant flies is significantly higher than in wild-type. Furthermore, average MEPPs amplitude is greater in CASK[X-307]/CASK[X-313] mutants. Latency values are much shorter in CASK[X-307]/CASK[X-313] mutants than in wild-type. In a walking optomotor assay, the frequency of correct turns is significantly lower in CASK[X-307]/CASK[X-313] mutants compared to wild-type flies. In a light intensity assay, the response of CASK[X-307]/CASK[X-313] mutants to decreasing light intensity mirrors that of wild-type flies. However, the response of CASK[X-307]/CASK[X-313] mutants at lower light intensities (below intermediate levels) suggest an impairment of visual function at low light intensity. CASK[X-307]/CASK[X-313] mutants exhibit a higher sustained ERG respones than in wild-type individuals. Although the ON transient amplitude is similar in both wild-type and CASK[X-307]/CASK[X-313] flies, OFF transients are significantly higher in CASK[X-307]/CASK[X-313] mutants than in wild-type individuals. These differences remain even when a high-intensity light stimulus is used instead of a low-intensity stimulus. Adaptation of the sustained response, induced by continuous 1Hz stimulation, is qualitatively similar in both CASK[X-307]/CASK[X-313] mutants and wild-type flies, whereas the amplitudes of the ERG sustained responses are significantly higher in CASK[X-307]/CASK[X-313] flies during the whole stimulation period.
CakiX-307/CakiX-313 double mutants fail to suppress courtship with mated females as normal and are defective for courtship habituation. Associative memory, is normal in mutants.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Not rescued by|
Expression of CASK[Scer\UAS.cZa] pan-neuronally under the control of Scer\GAL4[elav-C155] fully rescues the neuromuscular junction miniature end-plate potential as well as the giant fiber habituation response defects found in CASK[X-307]/CASK[X-313] mutant females but does not rescue any of these defects in male progeny.
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 7 )|
|Secondary FlyBase IDs|
|References ( 6 )|