Open Close
General Information
Symbol
Dmel\Fas2e93
Species
D. melanogaster
Name
FlyBase ID
FBal0048741
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
FasIIe93
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Precise excision of the P-element.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Dorsal longitudinal muscle a (DLMa) is innervated by a single motor neuron that has, on average, 5 contact points with the muscle in both wild type and Fas2e93 mutants.

Fas2e76/Fas2e93 transheterozygotes exhibit a 50% increase in number of MN boutons at muscle 6. Mild heat induced expression of CrebB-17Aa.hs during larval stages significantly increases the quantal content of the synapse without altering quantal size (as shown by measuring excitatory postsynaptic potential, EPSP). Homozygotes have a wild type bouton number, mild heat induced expression of CrebB-17Aa.hs during larval stages does not alter synaptic strength.

In homozygous embryos the SNb fails to diverge from the ISN partially (partial bypass) in 3% segments. Fas2e93; beat-Ia2 flies have a strong beat-Ia phenotype, 90% segments have a divergence defect.

In Fas2e76/Fas2e93 transheterozygotes growth of the synapse increases as Fas2 expression level is low causing a rise in number of boutons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)