FlyBase Allele Report: Dmel\Diap2[GMR.PH]

General Information

Symbol

Dmel\Diap2^GMR.PH

Species

D. melanogaster

Name

glass multimer reporter construct of Hay

FlyBase ID

FBal0048824

Feature type

allele

Associated gene

Dmel\Diap2

Associated Insertion(s)

Carried in Construct

P{GMR-DIAP2}

Also Known As

GMR-DIAP2

Key Links

Transgenic product class

cDNA

(Hay et al., 1995)

wild_type

(Hay et al., 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hay et al., 1995)

wild_type

(Hay et al., 1995)

Mutagen

in vitro construct

(Hay et al., 1995)

Progenitor genotype

Carried in construct

P{GMR-DIAP2}

Cytology

Description

GMR regulatory sequences drive expression of a Diap2 cDNA.

(Hay et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Diap2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | P-stage

(Hay et al., 1995)

pigment cell

(Hay et al., 1995)

Detailed Description

Statement

Reference

Normally occurring cell death (35-50hr postpupation) is blocked in eye development, giving rise to extra cells. Also blocks a second wave of normally occurring cell death that takes place between 60 and 70 hrs postpupation.

(Hay et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Diap2^GMR.PH is a suppressor of abnormal eye color phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Diap2^GMR.PH is a suppressor | partially of visible phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Diap2^GMR.PH, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Diap2^GMR.PH, Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Diap2^GMR.PH is a suppressor of visible phenotype of Rfx2^{202-480.UAS.Tag:HA}, Scer\GAL4^GMR.PS

(Otsuki et al., 2004)

Diap2^GMR.PH is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Diap2^GMR.PH is a suppressor of increased cell death phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Diap2^GMR.PH is a suppressor of visible phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Diap2^GMR.PH is a suppressor of abnormal cell death phenotype of hid^GMR.PG

(Hay et al., 1995)

Diap2^GMR.PH is a suppressor of abnormal cell death phenotype of rpr^GMR.PH

(Hay et al., 1995)

NOT Suppressor of

Statement

Reference

Diap2^GMR.PH is a non-suppressor of visible phenotype of Strica^GMR.PX

(Huh et al., 2007)

Diap2^GMR.PH is a non-suppressor of visible phenotype of Drice^P10.GMR, Drice^P20.GMR

(Huh et al., 2007)

Diap2^GMR.PH is a non-suppressor of visible phenotype of Dronc^GMR.PH

(Huh et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

Diap2^GMR.PH is a suppressor | partially of eye phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Diap2^GMR.PH is a suppressor | partially of interommatidial bristle phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Diap2^GMR.PH is a suppressor | partially of ommatidium phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Diap2^GMR.PH is a suppressor of eye phenotype of Scer\GAL4^GMR.PS, Syn2^NIG.4905R

(Nagai et al., 2010)

Diap2^GMR.PH, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Diap2^GMR.PH is a suppressor of eye phenotype of Rfx2^{202-480.UAS.Tag:HA}, Scer\GAL4^GMR.PS

(Otsuki et al., 2004)

Diap2^GMR.PH is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Diap2^GMR.PH is a suppressor of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Diap2^GMR.PH is a suppressor of eye phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Diap2^GMR.PH is a suppressor | partially of eye photoreceptor cell phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap2^GMR.PH is a suppressor | partially of pigment cell phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap2^GMR.PH is a suppressor | partially of eye phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap2^GMR.PH is a suppressor of eye phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap2^GMR.PH is a suppressor of photoreceptor neuron phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap2^GMR.PH is a suppressor of pigment cell phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap2^GMR.PH is a suppressor of cone cell phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

NOT Suppressor of

Statement

Reference

Diap2^GMR.PH is a non-suppressor of eye phenotype of Strica^GMR.PX

(Huh et al., 2007)

Diap2^GMR.PH is a non-suppressor of eye phenotype of Drice^P10.GMR, Drice^P20.GMR

(Huh et al., 2007)

Diap2^GMR.PH is a non-suppressor of eye phenotype of Dronc^GMR.PH

(Huh et al., 2007)

Diap2^GMR.PH, Scer\GAL4^GMR.PF is a non-suppressor of interommatidial bristle phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Iap2^GMR.PH in the developing eye suppresses the rough eye phenotype induced by expression of Syn2^NIG.4905R under the control of Scer\GAL4^GMR.PS.

(Nagai et al., 2010)

The rough eye phenotype seen upon expression of Dref^Scer\UAS.cSa in the developing eye under the control of Scer\GAL4^GMR.PS is suppressed by co-expression of Iap2^GMR.PH.

(Hirose et al., 2001)

Suppresses the rough eye phenotype of argos^GMR.PS : normal number of cone cells and primary pigment cells are restored in most ommatidia.

(Sawamoto et al., 1998)

Xenogenetic Interactions

Statement

Reference

Diap2^GMR.PH suppresses the reduction of eye pigments and weakly suppresses the abnormal formation of ommatidia and bristles and reduced eye size seen in Scer\GAL4^GMR.PS>Hsap\BCL2L13^Scer\UAS.cNa flies. Diap2^GMR.PH does not result in eye phenotypes in Scer\GAL4^GMR.PS>Hsap\BCL2L13^{ΔTM.Scer\UAS} flies.

(Nakazawa et al., 2016)

The addition of Iap2^GMR.PH suppresses the eye phenotype in Hsap\MAPT^GMR.Ex.PJ animals.

(Jackson et al., 2002)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5783

w^*; P{GMR-DIAP2}BH1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Diap2^GMR.PH

Iap2^GMR.PH

Name Synonyms

glass multimer reporter construct of Hay

(Hay et al., 1995)

Secondary FlyBase IDs

References (13)

Report Sections

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