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General Information
Symbol
Dmel\LarUAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Krueger
FlyBase ID
FBal0048853
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-LAR, UAS-Dlar
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Lar cDNA expression is governed by UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of LarScer\UAS.cKa under the control of Scer\GAL4Pdf.PU results in adult sLNv neurons exhibiting significantly longer axons compared to controls.

Expression of LarScer\UAS.cKa under the simultaneous control of both Scer\GAL4sca.PU and Scer\GAL4how-24B results in an increase in bouton number at the neuromuscular junction compared to wild type.

Expression of LarScer\UAS.cKa, under the control of Scer\GAL4elav-C155, causes bifurcation of the anterior and posterior branches of the SNa with a frequency of 23%. No ISNb phenotypes are observed.

Expression of LarScer\UAS.cKa during mid-larval development under the control of Scer\GAL4elav.PLu or Scer\GAL4elav-C155 results in an increase in bouton number at the muscle 6/7 neuromuscular junction compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Phenotype Manifest In
Suppressed by
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of LarScer\UAS.cKa under the control of Scer\GAL4elav-C155 in CadNΔ14 somatic mutant clones does not rescue the photoreceptor targeting defects.

Liprin-α1J-0/Liprin-αR117 larvae expressing LarScer\UAS.cKa under the control of Scer\GAL4elav.PLu show a reduction in bouton number at the muscle 6/7 neuromuscular junction equivalent to that seen in Liprin-α1J-0/Liprin-αR117 single mutants.

Partially suppresses the ISNb bypass phenotype of embryos expressing AblScer\UAS.cFa under the control of Scer\GAL4elav.PLu.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of LarScer\UAS.cKa under the control of Scer\GAL4elav-C155 almost completely rescues the aberrant axon extension in Lar2127 mutant photoreceptor cells.

Expression of LarScer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the reduction in bouton number at the neuromuscular junction seen in Lar5.5/Lar13.2 larvae, while expression under the control of Scer\GAL4how-24B does not rescue the mutant phenotype.

Partial rescue statement based on rescue of lethality. Fails to rescue statement based on larval ISNb and ISNd phenotype. Rescue statement based on rescue of oocyte phenotype of Lar13.2/Lar5.5 escapers.

Rescues the targeting defects of Lar5.5/Lar2127 R7 cell axons when expressed under the control of Scer\GAL4hs.2sev. Partially rescues the targeting defects of Lar5.5/Lar2127 R7 cell axons when expressed under the control of Scer\GAL4sca-109-68.

When expressed from Scer\GAL4elav-C155, LarScer\UAS.cKa rescues the Lar mutant phenotypes. The SNb choice point defect is almost completely rescued, and the embryonic lethality of Lar5.5/Lar13.2 is overcome.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
LarScer\UAS.cKa
LarUAS.cKa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Krueger
Secondary FlyBase IDs
    References (14)