Deletion removing N-terminal coding sequences, including the signal sequence and part of the first immunoglobulin domain. This enhanced phenotype is completely rescued by one copy of Ptp69D+t10.5.
abdominal segmental nerve
central nervous system
RP neuron & axon
Shows incompletely penetrant SNb (and, to a lesser extent, SNa) pathfinding defects. RP axons sometimes exhibit guidance errors within the CNS.
Ptp69D2 has RP neuron & axon phenotype, enhanceable by Ptp99A1
Ptp69D2 has abdominal segmental nerve phenotype, enhanceable by Ptp99A1
Penetrance and severity of mutant phenotypes is enhanced by Ptp99A1. The severity of the RP axon phenotype is enhanced by Ptp99A1.
Rank order for penetrance of SNb mutant phenotypes is Ptp69D1 > Ptp69D2 > Ptp69D1/Ptp69D3 > Ptp69D3.