FB2025_01 , released February 20, 2025
Allele: Dmel\Su(Tpl)S-192
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General Information
Symbol
Dmel\Su(Tpl)S-192
Species
D. melanogaster
Name
FlyBase ID
FBal0048982
Feature type
allele
Associated gene
Dmel\Su(Tpl)
Associated Insertion(s)
Carried in Construct
Also Known As
SR3-4AS-192
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Karim et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: R916G. Amino acid replacement: D918N. Amino acid replacement: S660L.

(Eissenberg, 2003.4.16)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,892,725..19,892,725 [-]
Nucleotide change:

C19892725T

Amino acid change:

S660L | Su(Tpl)-PA; S660L | Su(Tpl)-PB; S660L | Su(Tpl)-PC

Reported amino acid change:

S660L

Comment:

One of three @Su(Tpl) missense mutations in strain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Eissenberg, 2003.4.16)
point_mutation
3L:19,891,958..19,891,958 [-]
Nucleotide change:

C19891958G

Amino acid change:

R916G | Su(Tpl)-PA; R916G | Su(Tpl)-PB; R916G | Su(Tpl)-PC

Reported amino acid change:

R916G

Comment:

One of three @Su(Tpl) missense mutations in strain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Eissenberg, 2003.4.16)
point_mutation
3L:19,891,952..19,891,952 [-]
Nucleotide change:

G19891952A

Amino acid change:

D918N | Su(Tpl)-PA; D918N | Su(Tpl)-PB; D918N | Su(Tpl)-PC

Reported amino acid change:

D918N

Comment:

One of three @Su(Tpl) missense mutations in strain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Eissenberg, 2003.4.16)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      embryonic abdominal segment 1 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 1 (with Su(Tpl)s1)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 1 (with Su(Tpl)XS-706)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 2 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 2 (with Su(Tpl)s1)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 2 (with Su(Tpl)XS-706)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 3 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 3 (with Su(Tpl)17)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 4 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 4 (with Su(Tpl)17)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 4 (with Su(Tpl)XS-706)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 5 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 5 (with Su(Tpl)17)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 5 (with Su(Tpl)s1)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 6 (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 6 (with Su(Tpl)17)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 6 (with Su(Tpl)s1)

      (Eissenberg et al., 2002)

      embryonic abdominal segment 8 (with Su(Tpl)s1)

      (Eissenberg et al., 2002)

      embryonic head (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic head (with Su(Tpl)17)

      (Eissenberg et al., 2002)

      embryonic mesothoracic segment (with Su(Tpl)XS-706)

      (Eissenberg et al., 2002)

      embryonic metathoracic segment (with Su(Tpl)10)

      (Eissenberg et al., 2002)

      embryonic metathoracic segment (with Su(Tpl)XS-706)

      (Eissenberg et al., 2002)

      macrochaeta | somatic clone

      (Eissenberg et al., 2002)

      tormogen cell | somatic clone

      (Eissenberg et al., 2002)
      Detailed Description
      Statement
      Reference

      The hetero-allelic combination Su(Tpl)s1/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: abdominal segment 2 missing, incomplete or fused to abdominal segment 1; abdominal segment 6 broken or fused to abdominal segment 5; abdominal segment 8 missing. The hetero-allelic combination Su(Tpl)10/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: Mutant cuticles display the following defects, with variable penetrance: abdominal segment 2 missing, incomplete or fused to abdominal segment 3; abdominal segment 4 incomplete or fused to abdominal segment 3 or 5; metathoracic segment missing, incomplete or fused to abdominal segment 1; incomplete head involution. The hetero-allelic combination Su(Tpl)17/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: abdominal segment 4 missing or fused to abdominal segment 3 or 5; abdominal segment 6 incomplete or fused to abdominal segment 5; incomplete head involution. The hetero-allelic combination Su(Tpl)XS-706/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: metathoracic segment missing or fused to mesothoracic segment; abdominal segments 1, 2 and 4 often incomplete.

      (Eissenberg et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Su(Tpl)[+]/Su(Tpl)S-192 is an enhancer of partially lethal | male phenotype of Df(1)52, P{w+4Δ4.3}, lncRNA:roX1ex6, lncRNA:roX1t4.9

      (Prabhakaran and Kelley, 2012)

      Su(Tpl)[+]/Su(Tpl)S-192 is an enhancer of visible | dominant phenotype of Bx1

      (Bejarano et al., 2008)
      Suppressor of
      Statement
      Reference

      Su(Tpl)S-192 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Su(Tpl)[+]/Su(Tpl)S-192 is an enhancer of wing margin phenotype of Bx1

      (Bejarano et al., 2008)

      Su(Tpl)[+]/Su(Tpl)S-192 is an enhancer of wing margin phenotype of Nnd-1

      (Eissenberg et al., 2002)

      Su(Tpl)[+]/Su(Tpl)S-192 is an enhancer of wing margin phenotype of ct53d

      (Eissenberg et al., 2002)
      Suppressor of
      Statement
      Reference

      Su(Tpl)S-192 is a suppressor of phenotype of Ras85DV12.sev

      (Karim et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Su(Tpl)S-192.

      (Maixner et al., 1998)

      Suppresses the rough eye phenotype of Ras85DV12.sev. Enhances the phenotype of Ras85DN17.sev. Has little or no effect on the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Has little or no effect on the lethality of phl12. Has little or no effect on the phl12 eye phenotype. Has little or no effect on the Dsor1XS520 eye phenotype. Enhances the aopS2382 eye phenotype.

      (Karim et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      EllS-192
      (Chung et al., 2018)
      SR3-4AS-192
      (Eissenberg et al., 2002, Maixner et al., 1998, Karim et al., 1996)
      SR3-4aS-192
      (Rebay et al., 2000)
      SR3-4as-192
      (Neufeld et al., 1998)
      Su(Tpl)S-192
      (Bejarano et al., 2008)
      Su(Tpl)S192
      (Prabhakaran and Kelley, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)