T6650942A
V1069D | Taf1-PA; V1069D | Taf1-PB; V1069D | Taf1-PC; V1069D | Taf1-PD; V1112D | Taf1-PE; V1069D | Taf1-PF
V1072D
Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 4: RWEVIDV changes to RWEDIDV).
Amino acid replacement: V1072D.
Taf1EP421/Taf1XS-2232 flies have reduced bristle numbers on both male and female heads, are female sterile and are semi-lethal. They also display defects in oogenesis, ocelli development, and developmental timing. Ommatidia in Taf1EP421/Taf1XS-2232 flies are irregularly shaped and are not aligned in straight rows. The number of interommatidial bristles are reduced, multiple bristles sometimes originate from a single site and bristles are randomly distributed. The number of photoreceptor cells per ommatidium is also altered in these flies. Approximately 10% of ommatidia are missing one outer photoreceptor, and 14% have an extra outer photoreceptor. Taf1EP421/Taf1XS-2232 flies lack ocelli. Bristles on the thorax show normal morphology but are shifted from the normal orderly pattern. About 5% of Taf1EP421/Taf1XS-2232 males show an abnormal rotation of their terminalia during pupation. Wing development in Taf1EP421/Taf1XS-2232 is also disrupted. The wing vein L4 bifurcates along the wing margin forming a delta. The shape and size of the wings appear normal as does the morphology of the other wing veins. Wings are often held out to the sides of the body rather than crossed over the body as seen in wild-type. Taf1EP421/Taf1XS-2232 females are sterile with very small ovaries. Taf1EP421/Taf1XS-2232 flies develop about 2 days more slowly than wild-type.
Taf1XS-2232 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC
Ras85DV12.sev, Taf1XS-2232, sevS11.Tag:MYC has viable phenotype
Taf1XS-2232 is an enhancer of embryonic epidermis phenotype of dlunspecified
Taf1XS-2232 is an enhancer of embryonic/first instar larval cuticle phenotype of dlunspecified
Taf1[+]/Taf1XS-2232 is a non-enhancer of wing vein | ectopic phenotype of Snr1E1
Taf1XS-2232 is a suppressor of phenotype of Ras85DV12.sev
Taf1[+]/Taf1XS-2232 is a non-suppressor of wing vein | ectopic phenotype of Snr1E1
When Taf1XS-2232 is added to dlunspecified/+ sensitized embryos they exhibit a dorsalised and twisted body pattern.
The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Taf1XS-2232.
Suppresses the rough eye phenotype of Ras85DV12.sev. Slightly suppresses the phenotype of Ras85DN17.sev. Has little or no effect on the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Has little or no effect on the lethality of phl12. Has little or no effect on the phl12 eye phenotype. Has little or no effect on the Dsor1XS520 eye phenotype. Has little or no effect on the aopS2382 eye phenotype.
Alleles of Taf1 form an allelic series based on phenotypic strength: Taf1XS-2232/Taf1EP421 > Taf1S-136/Taf1EP421 > Taf1S-625/Taf1EP421 > Taf1EP421/Taf1EP421.