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General Information
Symbol
Dmel\Taf1XS-2232
Species
D. melanogaster
Name
FlyBase ID
FBal0048987
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
SR3-5XS-2232
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T6650942A

Amino acid change:

V1069D | Taf1-PA; V1069D | Taf1-PB; V1069D | Taf1-PC; V1069D | Taf1-PD; V1112D | Taf1-PE; V1069D | Taf1-PF

Reported amino acid change:

V1072D

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 4: RWEVIDV changes to RWEDIDV).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: V1072D.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Taf1EP421/Taf1XS-2232 flies have reduced bristle numbers on both male and female heads, are female sterile and are semi-lethal. They also display defects in oogenesis, ocelli development, and developmental timing. Ommatidia in Taf1EP421/Taf1XS-2232 flies are irregularly shaped and are not aligned in straight rows. The number of interommatidial bristles are reduced, multiple bristles sometimes originate from a single site and bristles are randomly distributed. The number of photoreceptor cells per ommatidium is also altered in these flies. Approximately 10% of ommatidia are missing one outer photoreceptor, and 14% have an extra outer photoreceptor. Taf1EP421/Taf1XS-2232 flies lack ocelli. Bristles on the thorax show normal morphology but are shifted from the normal orderly pattern. About 5% of Taf1EP421/Taf1XS-2232 males show an abnormal rotation of their terminalia during pupation. Wing development in Taf1EP421/Taf1XS-2232 is also disrupted. The wing vein L4 bifurcates along the wing margin forming a delta. The shape and size of the wings appear normal as does the morphology of the other wing veins. Wings are often held out to the sides of the body rather than crossed over the body as seen in wild-type. Taf1EP421/Taf1XS-2232 females are sterile with very small ovaries. Taf1EP421/Taf1XS-2232 flies develop about 2 days more slowly than wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
NOT Enhancer of
Statement
Reference

Taf1[+]/Taf1XS-2232 is a non-enhancer of wing vein | ectopic phenotype of Snr1E1

Suppressor of
Statement
Reference

Taf1XS-2232 is a suppressor of phenotype of Ras85DV12.sev

NOT Suppressor of
Statement
Reference

Taf1[+]/Taf1XS-2232 is a non-suppressor of wing vein | ectopic phenotype of Snr1E1

Additional Comments
Genetic Interactions
Statement
Reference

When Taf1XS-2232 is added to dlunspecified/+ sensitized embryos they exhibit a dorsalised and twisted body pattern.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Taf1XS-2232.

Suppresses the rough eye phenotype of Ras85DV12.sev. Slightly suppresses the phenotype of Ras85DN17.sev. Has little or no effect on the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Has little or no effect on the lethality of phl12. Has little or no effect on the phl12 eye phenotype. Has little or no effect on the Dsor1XS520 eye phenotype. Has little or no effect on the aopS2382 eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Alleles of Taf1 form an allelic series based on phenotypic strength: Taf1XS-2232/Taf1EP421 > Taf1S-136/Taf1EP421 > Taf1S-625/Taf1EP421 > Taf1EP421/Taf1EP421.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)