|Feature type||allele||Associated gene||Ctet\TeTxLC|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
(Mee et al., 2004, Fishilevich and Vosshall, 2005, Friggi-Grelin et al., 2003, Rodriguez Moncalvo and Campos, 2005, Renn et al., 1999, Suster and Bate, 2002, Luan et al., 2006, Inoshita and Tanimura, 2006, Sweeney et al., 1995, Mathew et al., 2003, Baines et al., 2002, Blanchardon et al., 2001, Gomez-Diaz et al., 2004, Baines et al., 2001, Kaneko et al., 2000, Baines et al., 1999, Allen et al., 1999, Hiesinger et al., 1999, Olofsson and Page, 2005, Tsai et al., 2004, de Celis et al., 1996, Bray and Amrein, 2003, Tracey et al., 2003, de Celis et al., 1997, de Celis, 1997, Suster et al., 2003, Devaud et al., 2003, Johard et al., 2009, Lu et al., 2012, Kwon et al., 2010, Morton et al., 2008, Ejima et al., 2007, Roy et al., 2007, Ai et al., 2010, Sadaf et al., 2012)
|Phenotype Manifest In|
Flies expressing Ctet\TeTxLC[IMPTNT-V.Scer\UAS] under the control of Scer\GAL4[Trh.PB] show normal flight ability in a cylinder drop test. Air-puff stimulated flight responses of the dorsal longitudinal indirect flight muscle (DLM) of tethered flies expressing Ctet\TeTxLC[IMPTNT-V.Scer\UAS] under the control of Scer\GAL4[Trh.PB] are normal.
Males expressing Ctet\TeTxLC[IMPTNT-V.Scer\UAS] under the control of either Scer\GAL4[Or65a.4.7] or Scer\GAL4[Or65a.PF] and treated with cis-vaccenyl acetate (cVa) show an inhibition of initial courtship of mature virgin females, as do wild-type males treated with cVa.
The normal architecture of the CSD interneuron (CSDn) is only slightly altered by targeted expression of Ctet\TeTxLC[IMPTNT-V.Scer\UAS] driven by Scer\GAL4[αTub84B.PP].
Ctet\TeTxLCIMPTNT.Scer\UAS; Scer\GAL4NP1017 adults starved of water for 2 hours a normal proboscis extension response when their prothoracic legs are exposed to water.
Expression of Ctet\TeTxLCIMPTNT-V.Scer\UAS throughout the CNS, using Scer\GAL4elav-C155 as the driver, does not affect embryonic ventral cord condensation.
Expression of Ctet\TeTxLCIMPTNT-V.Scer\UAS under the control of Scer\GAL4GMR.PF does not affect 5-HT arborization in larval brains.
When Ctet\TeTxLCIMPTNT-V.Scer\UAS is driven by Scer\GAL4P2.4.Pdf no effect is seen on sensitivity to cocaine.
The olfactory attraction and repulsion behaviour of flies expressing Ctet\TeTxLC[IMPTNT-V.Scer\UAS] under the control of either Scer\GAL4[85b] or Scer\GAL4[oeC] in response to various chemicals, including butanol, benzaldehyde, propionic acid and acetone, does not significantly differ from that of wild-type.
Adults expressing Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4ple.PF show a normal response in an assay in which flies are placed in a column with a conic bottom end and then suddenly tapped to the bottom to startle them.
When Ctet\TeTxLCIMPTNT-V.Scer\UAS is driven by Scer\GAL4109(2)80, mutant larvae exhibit a normal noxious heat response.
The average locomotor activity plots in light:dark (LD) cycles of flies expressing Ctet\TeTxLCIMPTNT-V.Scer\UAS under the control of Scer\GAL4per.PK or Scer\GAL4tim.PE is indistinguishable from those of control flies. Expression of Ctet\TeTxLCIMPTNT-V.Scer\UAS under the control of Scer\GAL4per.PK under constant darkness conditions does not result in a decrease in rhythmicity of locomotor behaviour. Expression of Ctet\TeTxLCIMPTNT-V.Scer\UAS under the control of Scer\GAL4tim.PE under constant darkness conditions results in a decrease in in the number of rhythmic flies in a locomotor activity assay.
When expression is driven by Scer\GAL4c17 in the giant fibre the response in the TTM to repetitive firing is wild type.
When Ctet\TeTxLCIMPTNT-V.Scer\UAS is driven by Scer\GAL4eve.RRC in aCC neurons, excitatory post-synaptic currents (epscs) are present in 14/18 neurons. Sustained inward currents are also seen in 14/18 neurons.
Flies expressing Ctet\TeTxLCIMPTNT-V.Scer\UAS under the control of Scer\GAL4MZ1369 have no obvious developmental defects. The wild-type columnar organisation of the medulla is recognisable in the optic lobes and the arborisations of the Fas2-positive lamina monopolar cells in the distal medulla are normal.
|Phenotype Manifest In|
per mutant files co-expressing per[Scer\UAS.cBa] and Ctet\TeTxLC[TNT.Scer\UAS] under the control of Scer\GAL4[Mai179] display morning anticipation in their locomotor activity, but they completely lose evening anticipation, compared with controls with Ctet\TeTxLC[IMPTNT-V.Scer\UAS] expression.
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 35 )|
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|List References by type|
|Recent research papers ( 2 )|